Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
SUM149PT Torin2
mTOR/ATM/ATR
PI3K/mTOR
0.14108
 0.0001 0.2579 0.0501 0.5792
0.76606
0.99281
SUM149PT Everolimus
mTOR1
PI3K/mTOR
Inf
 0.7389 0.2003 0.0098 0.2094
0.00021362
0.67353
SUM149PT INK-128
mTORC1/2
PI3K/mTOR
0.16131
 0.2613 0.3199 0.0092 0.6928
0.056936
0.98747
SUM149PT PF-4708671
p70S6K
PI3K/mTOR
20.5582
 0.7287 0.0241 0.0090 1.0700
53.3219
0.95776
SUM149PT Buparlisib
pan PI3K
PI3K/mTOR
1.4121
 -0.3357 0.2539 0.1216 1.9093
1.9133
0.99941
SUM149PT Pictilisib
pan PI3K
PI3K/mTOR
5.8499
 0.3333 0.1214 0.0038 0.7167
27.0916
0.9899
SUM149PT Ceritinib
ALK
RTK
1.6908
 -0.4396 0.2518 0.1219 2.1905
2.3199
0.99787
SUM149PT Neratinib
EGFR/HER2
RTK
0.067993
 0.1521 0.3623 0.0339 1.2974
0.048589
0.99455
SUM149PT Tivantinib
MET
RTK
0.27624
 -0.2313 0.4502 0.1850 2.3039
0.32281
0.99937
SUM149PT Cediranib
VEGFR/cKIT
RTK
5.5644
 0.0656 0.0552 0.0262 2.8599
6.1559
0.99049
SUM149PT Cabozantinib
VEGFR2/MET
RTK
5.7589
 0.2895 0.0383 0.0198 4.7896
4.9143
0.99303
T47D Abemaciclib
CDK4/6
Cell cycle
0.0042816
 -0.0412 0.7664 0.0265 1.3858
0.0037683
0.95899
T47D Palbociclib
CDK4/6
Cell cycle
0.027507
 0.1166 0.4501 0.0077 1.5536
0.022367
0.99262
T47D AZD7762
CHK1/2
Cell cycle
2.3432
 -0.0573 0.1322 0.0195 2.6709
2.4809
0.98871
T47D Volasertib
PLK
Cell cycle
0.031411
 -0.1585 0.3959 0.0580 1.7544
0.036365
0.99393
T47D Dinaciclib
pan CDK
Cell cycle
0.019853
 -0.2109 0.4815 0.0484 5.0000
0.021113
0.99494
T47D Cisplatin
Chemo
Chemotherapy
1.5698
 0.1019 0.2147 0.0055 1.3290
1.5705
0.98121
T47D Doxorubicin
Chemo
Chemotherapy
0.0018887
 -0.3611 0.9189 0.1014 1.2268
0.0024801
0.96538
T47D Taxol
Chemo
Chemotherapy
0.0035285
 -0.1337 0.6636 0.2505 2.2353
0.0038792
0.99665
T47D Topotecan
Topo I
Chemotherapy
0.0052275
 -0.1971 0.9594 0.1261 1.3094
0.0068541
0.99083
T47D Etoposide
Topo II
Chemotherapy
0.041662
 -0.1861 0.6661 0.0533 1.1976
0.051932
0.98563
T47D Dasatinib
BCR/ABL
MAPK/nRTK
12.5697
 0.4961 0.1933 0.0086 0.2753
679.7315
0.95229
T47D Trametinib
MEK
MAPK/nRTK
Inf
 0.5801 0.2130 0.0041 0.9941
0.0048584
0.90394
T47D Saracatinib
SRC
MAPK/nRTK
3.9647
 0.3892 0.1722 0.0087 0.6928
1.6318
0.9752
T47D ABT-737
Bcl2/XL
Misc
12.2023
 0.5888 0.0010 0.0084 2.2890
9.7541
0.92156