Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
HCC1143 Taselisib
0.31623
PI3Ka, g, d
PI3K/mTOR
 0.4438 0.08285
HCC1143 Taselisib
1.0
PI3Ka, g, d
PI3K/mTOR
 0.3299 0.11304
HCC1143 Taselisib
3.1623
PI3Ka, g, d
PI3K/mTOR
 0.1361 0.16444
HCC1143 Taselisib
10.0
PI3Ka, g, d
PI3K/mTOR
 -0.0942 0.31177
HCC1143 TGX221
0.001
PI3Kb
PI3K/mTOR
 1.0196 -0.00256
HCC1143 TGX221
0.0031623
PI3Kb
PI3K/mTOR
 1.0242 0.00294
HCC1143 TGX221
0.01
PI3Kb
PI3K/mTOR
 1.0629 0.00343
HCC1143 TGX221
0.031623
PI3Kb
PI3K/mTOR
 0.9256 0.00566
HCC1143 TGX221
0.1
PI3Kb
PI3K/mTOR
 0.9580 0.00117
HCC1143 TGX221
0.31623
PI3Kb
PI3K/mTOR
 0.9177 0.00456
HCC1143 TGX221
1.0
PI3Kb
PI3K/mTOR
 0.9412 -0.00083
HCC1143 TGX221
3.1623
PI3Kb
PI3K/mTOR
 0.9365 0.00694
HCC1143 TGX221
10.0
PI3Kb
PI3K/mTOR
 0.9185 0.01500
HCC1143 Torin2
0.0001
mTOR/ATM/ATR
PI3K/mTOR
 0.9337 0.00152
HCC1143 Torin2
0.00031623
mTOR/ATM/ATR
PI3K/mTOR
 1.0512 0.00084
HCC1143 Torin2
0.001
mTOR/ATM/ATR
PI3K/mTOR
 1.0634 -0.00277
HCC1143 Torin2
0.0031623
mTOR/ATM/ATR
PI3K/mTOR
 0.9192 0.00343
HCC1143 Torin2
0.01
mTOR/ATM/ATR
PI3K/mTOR
 0.8380 0.01165
HCC1143 Torin2
0.031623
mTOR/ATM/ATR
PI3K/mTOR
 0.6190 0.04947
HCC1143 Torin2
0.1
mTOR/ATM/ATR
PI3K/mTOR
 0.2301 0.17551
HCC1143 Torin2
0.31623
mTOR/ATM/ATR
PI3K/mTOR
 -0.0103 0.26875
HCC1143 Torin2
1.0
mTOR/ATM/ATR
PI3K/mTOR
 -0.1535 0.25708
HCC1143 Everolimus
0.001
mTOR1
PI3K/mTOR
 0.7671 0.01542
HCC1143 Everolimus
0.0031623
mTOR1
PI3K/mTOR
 0.6791 0.02139
HCC1143 Everolimus
0.01
mTOR1
PI3K/mTOR
 0.6635 0.02346