Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
CAL-85-1 Buparlisib
3.1623
pan PI3K
PI3K/mTOR
 -0.2114 0.39778
CAL-85-1 Buparlisib
10.0
pan PI3K
PI3K/mTOR
 -0.3199 0.36541
CAL-85-1 Pictilisib
0.001
pan PI3K
PI3K/mTOR
 0.9959 0.00030
CAL-85-1 Pictilisib
0.0031623
pan PI3K
PI3K/mTOR
 0.9349 0.00127
CAL-85-1 Pictilisib
0.01
pan PI3K
PI3K/mTOR
 0.9550 0.00390
CAL-85-1 Pictilisib
0.031623
pan PI3K
PI3K/mTOR
 0.7511 0.01572
CAL-85-1 Pictilisib
0.1
pan PI3K
PI3K/mTOR
 0.6636 0.01619
CAL-85-1 Pictilisib
0.31623
pan PI3K
PI3K/mTOR
 0.6070 0.01956
CAL-85-1 Pictilisib
1.0
pan PI3K
PI3K/mTOR
 0.4268 0.06800
CAL-85-1 Pictilisib
3.1623
pan PI3K
PI3K/mTOR
 0.2971 0.06238
CAL-85-1 Pictilisib
10.0
pan PI3K
PI3K/mTOR
 -0.0252 0.18282
CAL-85-1 Ceritinib
0.001
ALK
RTK
 1.0415 0.00233
CAL-85-1 Ceritinib
0.0031623
ALK
RTK
 0.9920 -0.00367
CAL-85-1 Ceritinib
0.01
ALK
RTK
 0.9540 -0.00669
CAL-85-1 Ceritinib
0.031623
ALK
RTK
 0.9664 -0.00697
CAL-85-1 Ceritinib
0.1
ALK
RTK
 0.9014 -0.00337
CAL-85-1 Ceritinib
0.31623
ALK
RTK
 0.7548 0.00774
CAL-85-1 Ceritinib
1.0
ALK
RTK
 0.3847 0.05712
CAL-85-1 Ceritinib
3.1623
ALK
RTK
 -0.1556 0.16462
CAL-85-1 Ceritinib
10.0
ALK
RTK
 -0.5961 0.31598
CAL-85-1 Neratinib
0.00031623
EGFR/HER2
RTK
 1.0339 -0.00222
CAL-85-1 Neratinib
0.001
EGFR/HER2
RTK
 1.0034 0.00154
CAL-85-1 Neratinib
0.0031623
EGFR/HER2
RTK
 0.8861 0.00454
CAL-85-1 Neratinib
0.01
EGFR/HER2
RTK
 0.7207 0.04203
CAL-85-1 Neratinib
0.031623
EGFR/HER2
RTK
 0.4306 0.11505