Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
CAL-85-1 INK-128
0.00031623
mTORC1/2
PI3K/mTOR
 0.9729 0.00349
CAL-85-1 INK-128
0.001
mTORC1/2
PI3K/mTOR
 0.9213 0.00034
CAL-85-1 INK-128
0.0031623
mTORC1/2
PI3K/mTOR
 0.8086 0.00550
CAL-85-1 INK-128
0.01
mTORC1/2
PI3K/mTOR
 0.4661 0.04688
CAL-85-1 INK-128
0.031623
mTORC1/2
PI3K/mTOR
 0.1519 0.09824
CAL-85-1 INK-128
0.1
mTORC1/2
PI3K/mTOR
 0.0597 0.08330
CAL-85-1 INK-128
0.31623
mTORC1/2
PI3K/mTOR
 0.0598 0.09279
CAL-85-1 INK-128
1.0
mTORC1/2
PI3K/mTOR
 0.0322 0.10660
CAL-85-1 INK-128
3.1623
mTORC1/2
PI3K/mTOR
 0.0160 0.12484
CAL-85-1 PF-4708671
0.001
p70S6K
PI3K/mTOR
 1.0071 0.00277
CAL-85-1 PF-4708671
0.0031623
p70S6K
PI3K/mTOR
 0.9852 0.01237
CAL-85-1 PF-4708671
0.01
p70S6K
PI3K/mTOR
 1.0644 -0.00156
CAL-85-1 PF-4708671
0.031623
p70S6K
PI3K/mTOR
 1.0937 0.00323
CAL-85-1 PF-4708671
0.1
p70S6K
PI3K/mTOR
 1.0411 -0.00818
CAL-85-1 PF-4708671
0.31623
p70S6K
PI3K/mTOR
 1.0576 -0.00002
CAL-85-1 PF-4708671
1.0
p70S6K
PI3K/mTOR
 0.9639 0.00265
CAL-85-1 PF-4708671
3.1623
p70S6K
PI3K/mTOR
 1.0208 0.00869
CAL-85-1 PF-4708671
10.0
p70S6K
PI3K/mTOR
 1.0427 0.01172
CAL-85-1 Buparlisib
0.001
pan PI3K
PI3K/mTOR
 1.0103 0.00147
CAL-85-1 Buparlisib
0.0031623
pan PI3K
PI3K/mTOR
 0.9868 -0.00872
CAL-85-1 Buparlisib
0.01
pan PI3K
PI3K/mTOR
 0.9758 0.00006
CAL-85-1 Buparlisib
0.031623
pan PI3K
PI3K/mTOR
 0.8960 0.00277
CAL-85-1 Buparlisib
0.1
pan PI3K
PI3K/mTOR
 0.7501 0.01721
CAL-85-1 Buparlisib
0.31623
pan PI3K
PI3K/mTOR
 0.5715 0.05198
CAL-85-1 Buparlisib
1.0
pan PI3K
PI3K/mTOR
 0.1501 0.19498