Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)
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Cell | Small Molecule | Small Mol Concentration (uM) | Primary Target | Pathway | Mean Normalized Growth Rate Inhibition Value | Increased Fraction Dead |
---|---|---|---|---|---|---|
HCC1806 | Abemaciclib | 0.001 | CDK4/6 | Cell cycle | 0.9779 | 0.00362 |
HCC1806 | Abemaciclib | 0.0031623 | CDK4/6 | Cell cycle | 0.9667 | -0.00301 |
HCC1806 | Abemaciclib | 0.01 | CDK4/6 | Cell cycle | 0.9168 | 0.00484 |
HCC1806 | Abemaciclib | 0.031623 | CDK4/6 | Cell cycle | 0.7658 | 0.01650 |
HCC1806 | Abemaciclib | 0.1 | CDK4/6 | Cell cycle | 0.7132 | 0.01025 |
HCC1806 | Abemaciclib | 0.31623 | CDK4/6 | Cell cycle | 0.6567 | 0.01780 |
HCC1806 | Abemaciclib | 1.0 | CDK4/6 | Cell cycle | 0.4501 | 0.04250 |
HCC1806 | Abemaciclib | 3.1623 | CDK4/6 | Cell cycle | 0.1267 | 0.14911 |
HCC1806 | Abemaciclib | 10.0 | CDK4/6 | Cell cycle | -0.4440 | 0.69010 |
HCC1806 | Palbociclib | 0.00031623 | CDK4/6 | Cell cycle | 1.0473 | 0.00007 |
HCC1806 | Palbociclib | 0.001 | CDK4/6 | Cell cycle | 1.0121 | 0.00165 |
HCC1806 | Palbociclib | 0.0031623 | CDK4/6 | Cell cycle | 0.9535 | -0.00157 |
HCC1806 | Palbociclib | 0.01 | CDK4/6 | Cell cycle | 0.9497 | 0.00431 |
HCC1806 | Palbociclib | 0.031623 | CDK4/6 | Cell cycle | 0.8470 | 0.00941 |
HCC1806 | Palbociclib | 0.1 | CDK4/6 | Cell cycle | 0.7323 | 0.02268 |
HCC1806 | Palbociclib | 0.31623 | CDK4/6 | Cell cycle | 0.7287 | 0.01539 |
HCC1806 | Palbociclib | 1.0 | CDK4/6 | Cell cycle | 0.6924 | 0.01844 |
HCC1806 | Palbociclib | 3.1623 | CDK4/6 | Cell cycle | 0.7848 | 0.00614 |
HCC1806 | AZD7762 | 0.001 | CHK1/2 | Cell cycle | 1.0370 | 0.00365 |
HCC1806 | AZD7762 | 0.0031623 | CHK1/2 | Cell cycle | 0.9973 | 0.00852 |
HCC1806 | AZD7762 | 0.01 | CHK1/2 | Cell cycle | 0.7268 | 0.06774 |
HCC1806 | AZD7762 | 0.031623 | CHK1/2 | Cell cycle | 0.1254 | 0.31387 |
HCC1806 | AZD7762 | 0.1 | CHK1/2 | Cell cycle | -0.2483 | 0.52952 |
HCC1806 | AZD7762 | 0.31623 | CHK1/2 | Cell cycle | -0.2887 | 0.58594 |
HCC1806 | AZD7762 | 1.0 | CHK1/2 | Cell cycle | -0.3313 | 0.62585 |