Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
MMAC-SF Vemurafenib Defactinib 1.000 0.316
uM
 72
hr
 2 759 236 0.3222 0.2855 0.3109 0.3352
MMAC-SF Vemurafenib Defactinib 1.000 0.316
uM
 72
hr
 3 750 271 0.2951 0.2855 0.3613 0.3352
MMAC-SF Vemurafenib Defactinib 1.000 1.000
uM
 72
hr
 1 828 289 0.3321 0.2820 0.3490 0.3755
MMAC-SF Vemurafenib Defactinib 1.000 1.000
uM
 72
hr
 2 734 263 0.2902 0.2820 0.3583 0.3755
MMAC-SF Vemurafenib Defactinib 1.000 1.000
uM
 72
hr
 3 625 262 0.2237 0.2820 0.4192 0.3755
MMAC-SF Vemurafenib Defactinib 1.000 3.160
uM
 72
hr
 1 525 202 0.1990 0.1742 0.3848 0.4178
MMAC-SF Vemurafenib Defactinib 1.000 3.160
uM
 72
hr
 2 454 186 0.1651 0.1742 0.4097 0.4178
MMAC-SF Vemurafenib Defactinib 1.000 3.160
uM
 72
hr
 3 475 218 0.1583 0.1742 0.4589 0.4178
MMAC-SF Vemurafenib Defactinib 3.160 0.000
uM
 72
hr
 1 591 241 0.2157 0.2403 0.4078 0.4433
MMAC-SF Vemurafenib Defactinib 3.160 0.000
uM
 72
hr
 2 706 324 0.2354 0.2403 0.4589 0.4433
MMAC-SF Vemurafenib Defactinib 3.160 0.000
uM
 72
hr
 3 816 378 0.2699 0.2403 0.4632 0.4433
MMAC-SF Vemurafenib Defactinib 3.160 0.316
uM
 72
hr
 1 453 159 0.1811 0.1801 0.3510 0.3728
MMAC-SF Vemurafenib Defactinib 3.160 0.316
uM
 72
hr
 2 487 187 0.1848 0.1801 0.3840 0.3728
MMAC-SF Vemurafenib Defactinib 3.160 0.316
uM
 72
hr
 3 459 176 0.1744 0.1801 0.3834 0.3728
MMAC-SF Vemurafenib Defactinib 3.160 1.000
uM
 72
hr
 1 732 297 0.2680 0.2245 0.4057 0.3979
MMAC-SF Vemurafenib Defactinib 3.160 1.000
uM
 72
hr
 2 647 263 0.2366 0.2245 0.4065 0.3979
MMAC-SF Vemurafenib Defactinib 3.160 1.000
uM
 72
hr
 3 443 169 0.1688 0.2245 0.3815 0.3979
MMAC-SF Vemurafenib Defactinib 3.160 3.160
uM
 72
hr
 1 431 171 0.1602 0.1471 0.3968 0.4142
MMAC-SF Vemurafenib Defactinib 3.160 3.160
uM
 72
hr
 2 414 180 0.1442 0.1471 0.4348 0.4142
MMAC-SF Vemurafenib Defactinib 3.160 3.160
uM
 72
hr
 3 377 155 0.1368 0.1471 0.4111 0.4142
MMAC-SF Vemurafenib JNK-IN-8 0.000 0.000
uM
 72
hr
 1 938 63 0.8592 1.0000 0.0672 0.0564
MMAC-SF Vemurafenib JNK-IN-8 0.000 0.000
uM
 72
hr
 2 1195 71 1.1038 1.0000 0.0594 0.0564
MMAC-SF Vemurafenib JNK-IN-8 0.000 0.000
uM
 72
hr
 3 1103 47 1.0370 1.0000 0.0426 0.0564
MMAC-SF Vemurafenib JNK-IN-8 0.000 0.316
uM
 72
hr
 1 1158 56 1.0822 1.3028 0.0484 0.0415
MMAC-SF Vemurafenib JNK-IN-8 0.000 0.316
uM
 72
hr
 2 1516 54 1.4357 1.3028 0.0356 0.0415