Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
MZ7-mel Vemurafenib Dasatinib 3.160 0.000
uM
 72
hr
 3 1844 548 0.2606 0.2350 0.2972 0.3040
MZ7-mel Vemurafenib Dasatinib 3.160 0.316
uM
 72
hr
 1 776 178 0.1203 0.1382 0.2294 0.2130
MZ7-mel Vemurafenib Dasatinib 3.160 0.316
uM
 72
hr
 2 873 185 0.1384 0.1382 0.2119 0.2130
MZ7-mel Vemurafenib Dasatinib 3.160 0.316
uM
 72
hr
 3 966 191 0.1559 0.1382 0.1977 0.2130
MZ7-mel Vemurafenib Dasatinib 3.160 1.000
uM
 72
hr
 1 1480 268 0.2437 0.1804 0.1811 0.1862
MZ7-mel Vemurafenib Dasatinib 3.160 1.000
uM
 72
hr
 2 1077 200 0.1764 0.1804 0.1857 0.1862
MZ7-mel Vemurafenib Dasatinib 3.160 1.000
uM
 72
hr
 3 745 143 0.1211 0.1804 0.1919 0.1862
MZ7-mel Vemurafenib Dasatinib 3.160 3.160
uM
 72
hr
 1 694 119 0.1156 0.1047 0.1715 0.1707
MZ7-mel Vemurafenib Dasatinib 3.160 3.160
uM
 72
hr
 2 655 118 0.1080 0.1047 0.1802 0.1707
MZ7-mel Vemurafenib Dasatinib 3.160 3.160
uM
 72
hr
 3 536 86 0.0905 0.1047 0.1604 0.1707
MZ7-mel Vemurafenib Defactinib 0.000 0.000
uM
 72
hr
 1 4309 194 0.9042 1.0000 0.0450 0.0565
MZ7-mel Vemurafenib Defactinib 0.000 0.000
uM
 72
hr
 2 4980 306 1.0270 1.0000 0.0614 0.0565
MZ7-mel Vemurafenib Defactinib 0.000 0.000
uM
 72
hr
 3 5192 328 1.0688 1.0000 0.0632 0.0565
MZ7-mel Vemurafenib Defactinib 0.000 0.316
uM
 72
hr
 1 4690 306 0.9633 1.1499 0.0652 0.0651
MZ7-mel Vemurafenib Defactinib 0.000 0.316
uM
 72
hr
 2 6042 428 1.2336 1.1499 0.0708 0.0651
MZ7-mel Vemurafenib Defactinib 0.000 0.316
uM
 72
hr
 3 6060 359 1.2527 1.1499 0.0592 0.0651
MZ7-mel Vemurafenib Defactinib 0.000 1.000
uM
 72
hr
 1 3170 304 0.6298 0.5441 0.0959 0.0907
MZ7-mel Vemurafenib Defactinib 0.000 1.000
uM
 72
hr
 2 2678 231 0.5377 0.5441 0.0863 0.0907
MZ7-mel Vemurafenib Defactinib 0.000 1.000
uM
 72
hr
 3 2325 209 0.4650 0.5441 0.0899 0.0907
MZ7-mel Vemurafenib Defactinib 0.000 3.160
uM
 72
hr
 1 2670 269 0.5276 0.4271 0.1007 0.0911
MZ7-mel Vemurafenib Defactinib 0.000 3.160
uM
 72
hr
 2 2321 186 0.4691 0.4271 0.0801 0.0911
MZ7-mel Vemurafenib Defactinib 0.000 3.160
uM
 72
hr
 3 1427 132 0.2846 0.4271 0.0925 0.0911
MZ7-mel Vemurafenib Defactinib 0.100 0.000
uM
 72
hr
 1 2703 149 0.5612 0.6005 0.0551 0.0470
MZ7-mel Vemurafenib Defactinib 0.100 0.000
uM
 72
hr
 2 3076 137 0.6458 0.6005 0.0445 0.0470
MZ7-mel Vemurafenib Defactinib 0.100 0.000
uM
 72
hr
 3 2823 117 0.5946 0.6005 0.0414 0.0470