Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
MZ7-mel Vemurafenib Defactinib 0.100 0.316
uM
 72
hr
 1 3089 162 0.6432 0.7316 0.0524 0.0510
MZ7-mel Vemurafenib Defactinib 0.100 0.316
uM
 72
hr
 2 3707 187 0.7735 0.7316 0.0504 0.0510
MZ7-mel Vemurafenib Defactinib 0.100 0.316
uM
 72
hr
 3 3728 187 0.7781 0.7316 0.0502 0.0510
MZ7-mel Vemurafenib Defactinib 0.100 1.000
uM
 72
hr
 1 3137 164 0.6533 0.5810 0.0523 0.0554
MZ7-mel Vemurafenib Defactinib 0.100 1.000
uM
 72
hr
 2 2989 169 0.6196 0.5810 0.0565 0.0554
MZ7-mel Vemurafenib Defactinib 0.100 1.000
uM
 72
hr
 3 2269 130 0.4700 0.5810 0.0573 0.0554
MZ7-mel Vemurafenib Defactinib 0.100 3.160
uM
 72
hr
 1 2406 189 0.4871 0.3889 0.0786 0.0733
MZ7-mel Vemurafenib Defactinib 0.100 3.160
uM
 72
hr
 2 2079 121 0.4302 0.3889 0.0582 0.0733
MZ7-mel Vemurafenib Defactinib 0.100 3.160
uM
 72
hr
 3 1238 103 0.2494 0.3889 0.0832 0.0733
MZ7-mel Vemurafenib Defactinib 0.316 0.000
uM
 72
hr
 1 2049 144 0.4186 0.4924 0.0703 0.0784
MZ7-mel Vemurafenib Defactinib 0.316 0.000
uM
 72
hr
 2 2738 237 0.5495 0.4924 0.0866 0.0784
MZ7-mel Vemurafenib Defactinib 0.316 0.000
uM
 72
hr
 3 2514 197 0.5091 0.4924 0.0784 0.0784
MZ7-mel Vemurafenib Defactinib 0.316 0.316
uM
 72
hr
 1 2265 181 0.4579 0.4826 0.0799 0.0734
MZ7-mel Vemurafenib Defactinib 0.316 0.316
uM
 72
hr
 2 2225 149 0.4562 0.4826 0.0670 0.0734
MZ7-mel Vemurafenib Defactinib 0.316 0.316
uM
 72
hr
 3 2621 192 0.5337 0.4826 0.0733 0.0734
MZ7-mel Vemurafenib Defactinib 0.316 1.000
uM
 72
hr
 1 2302 149 0.4731 0.3676 0.0647 0.0695
MZ7-mel Vemurafenib Defactinib 0.316 1.000
uM
 72
hr
 2 1757 126 0.3584 0.3676 0.0717 0.0695
MZ7-mel Vemurafenib Defactinib 0.316 1.000
uM
 72
hr
 3 1331 96 0.2714 0.3676 0.0721 0.0695
MZ7-mel Vemurafenib Defactinib 0.316 3.160
uM
 72
hr
 1 1810 159 0.3628 0.3008 0.0878 0.0870
MZ7-mel Vemurafenib Defactinib 0.316 3.160
uM
 72
hr
 2 1659 156 0.3303 0.3008 0.0940 0.0870
MZ7-mel Vemurafenib Defactinib 0.316 3.160
uM
 72
hr
 3 1035 82 0.2094 0.3008 0.0792 0.0870
MZ7-mel Vemurafenib Defactinib 1.000 0.000
uM
 72
hr
 1 1993 318 0.3681 0.3928 0.1596 0.1549
MZ7-mel Vemurafenib Defactinib 1.000 0.000
uM
 72
hr
 2 2165 324 0.4045 0.3928 0.1497 0.1549
MZ7-mel Vemurafenib Defactinib 1.000 0.000
uM
 72
hr
 3 2187 340 0.4058 0.3928 0.1555 0.1549
MZ7-mel Vemurafenib Defactinib 1.000 0.316
uM
 72
hr
 1 1421 136 0.2824 0.3139 0.0957 0.1064