Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
MMAC-SF Vemurafenib Defactinib 0.100 0.316
uM
 72
hr
 1 937 74 0.5317 0.6679 0.0790 0.0750
MMAC-SF Vemurafenib Defactinib 0.100 0.316
uM
 72
hr
 2 1266 94 0.7221 0.6679 0.0742 0.0750
MMAC-SF Vemurafenib Defactinib 0.100 0.316
uM
 72
hr
 3 1311 94 0.7498 0.6679 0.0717 0.0750
MMAC-SF Vemurafenib Defactinib 0.100 1.000
uM
 72
hr
 1 1062 98 0.5940 0.5287 0.0923 0.0889
MMAC-SF Vemurafenib Defactinib 0.100 1.000
uM
 72
hr
 2 970 85 0.5453 0.5287 0.0876 0.0889
MMAC-SF Vemurafenib Defactinib 0.100 1.000
uM
 72
hr
 3 794 69 0.4467 0.5287 0.0869 0.0889
MMAC-SF Vemurafenib Defactinib 0.100 3.160
uM
 72
hr
 1 904 113 0.4874 0.4387 0.1250 0.1238
MMAC-SF Vemurafenib Defactinib 0.100 3.160
uM
 72
hr
 2 898 102 0.4904 0.4387 0.1136 0.1238
MMAC-SF Vemurafenib Defactinib 0.100 3.160
uM
 72
hr
 3 633 84 0.3383 0.4387 0.1327 0.1238
MMAC-SF Vemurafenib Defactinib 0.316 0.000
uM
 72
hr
 1 893 157 0.4535 0.5003 0.1758 0.1840
MMAC-SF Vemurafenib Defactinib 0.316 0.000
uM
 72
hr
 2 1048 218 0.5114 0.5003 0.2080 0.1840
MMAC-SF Vemurafenib Defactinib 0.316 0.000
uM
 72
hr
 3 1046 176 0.5360 0.5003 0.1683 0.1840
MMAC-SF Vemurafenib Defactinib 0.316 0.316
uM
 72
hr
 1 881 194 0.4233 0.4219 0.2202 0.2479
MMAC-SF Vemurafenib Defactinib 0.316 0.316
uM
 72
hr
 2 887 228 0.4060 0.4219 0.2570 0.2479
MMAC-SF Vemurafenib Defactinib 0.316 0.316
uM
 72
hr
 3 965 257 0.4362 0.4219 0.2663 0.2479
MMAC-SF Vemurafenib Defactinib 0.316 1.000
uM
 72
hr
 1 951 257 0.4276 0.3619 0.2702 0.2613
MMAC-SF Vemurafenib Defactinib 0.316 1.000
uM
 72
hr
 2 826 215 0.3765 0.3619 0.2603 0.2613
MMAC-SF Vemurafenib Defactinib 0.316 1.000
uM
 72
hr
 3 612 155 0.2816 0.3619 0.2533 0.2613
MMAC-SF Vemurafenib Defactinib 0.316 3.160
uM
 72
hr
 1 736 230 0.3118 0.2686 0.3125 0.3262
MMAC-SF Vemurafenib Defactinib 0.316 3.160
uM
 72
hr
 2 640 211 0.2643 0.2686 0.3297 0.3262
MMAC-SF Vemurafenib Defactinib 0.316 3.160
uM
 72
hr
 3 562 189 0.2298 0.2686 0.3363 0.3262
MMAC-SF Vemurafenib Defactinib 1.000 0.000
uM
 72
hr
 1 747 248 0.3075 0.3551 0.3320 0.3208
MMAC-SF Vemurafenib Defactinib 1.000 0.000
uM
 72
hr
 2 916 305 0.3765 0.3551 0.3330 0.3208
MMAC-SF Vemurafenib Defactinib 1.000 0.000
uM
 72
hr
 3 881 262 0.3814 0.3551 0.2974 0.3208
MMAC-SF Vemurafenib Defactinib 1.000 0.316
uM
 72
hr
 1 582 194 0.2391 0.2855 0.3333 0.3352