Breast Cancer Cell Density: Imaging assay of the density- and context-dependence of small molecule perturbagen response in breast cancer cell lines. Dataset 3 of 3: Calculated dose-response metrics. - Dataset (ID:20258)

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Cell Small Molecule Replicate Seeding Density IC50 EC50 Emax Einf IC Hill Coefficient IC_AUC IC Curve Fit IC r2 GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR Curve Fit GR r2
SK-BR-3 Linsitinib 9 312.50
23.384
23.3753
 0.6854 0.0009 4.9931 1.0022
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.8416
17.9324
22.339
 0.2633 -1.0000 5.0000 0.0026
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9549
SK-BR-3 Linsitinib 9 625.00
36.0947
36.0947
 0.6514 0.0000 1.1986 0.9806
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.8768
14.3799
36.7491
 0.3000 -1.0000 1.1709 0.0655
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9245
SK-BR-3 Linsitinib 9 1250.00
32.0336
32.0336
 0.5655 0.0000 0.7510 0.9328
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9072
10.5001
48.6073
 0.2677 -1.0000 0.7169 0.1232
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9315
SK-BR-3 Linsitinib 9 2500.00
38.774
37.8633
 0.6199 0.0099 0.8410 0.9572
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9067
11.5717
45.1607
 0.2859 -1.0000 0.8068 0.0977
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9394
SK-BR-3 Linsitinib 9 5000.00
inf
7.5266
 0.6977 0.5931 0.9411 0.9461
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9684
6.7469
6.119
 0.2426 0.0454 0.9745 0.1405
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.969
SK-BR-3 17-AAG 9 156.25
inf
0.0043
 0.5581 0.5708 2.0315 0.7948
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9197
0.003
0.0038
 -0.4063 -0.3594 2.1526 0.6932
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9193
SK-BR-3 17-AAG 9 312.50
0.0417
0.0074
 0.4359 0.4658 1.5499 0.7811
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.973
0.0057
0.0078
 -0.3653 -0.3105 1.5841 0.5481
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9903
SK-BR-3 17-AAG 9 625.00
0.0221
0.0094
 0.3937 0.4103 2.0137 0.7745
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9824
0.0081
0.0095
 -0.2193 -0.1863 2.0149 0.4712
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9936
SK-BR-3 17-AAG 9 1250.00
0.0132
0.0074
 0.3623 0.3969 2.7260 0.7335
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9885
0.0074
0.0076
 -0.1115 -0.0459 2.6632 0.4600
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9908
SK-BR-3 17-AAG 9 2500.00
0.0261
0.0111
 0.3783 0.4100 2.0015 0.7905
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9816
0.0101
0.0114
 -0.1859 -0.1292 1.9096 0.4127
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9895
SK-BR-3 17-AAG 9 5000.00
inf
0.0241
 0.4943 0.5062 1.9941 0.8573
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9935
0.0197
0.0229
 -0.2129 -0.1843 2.0485 0.3519
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9951
MDA-MB-231 NVP-TAE684 2 156.25
1.2344
1.0426
 0.2762 0.2850 5.0000 0.8500
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.983
0.973
1.0639
 -0.3010 -0.2818 5.0000 0.2908
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9941
MDA-MB-231 NVP-TAE684 2 312.50
1.4749
1.1269
 0.2208 0.2125 2.0569 0.8222
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9893
0.9778
1.2586
 -0.3201 -0.3385 2.0480 0.2993
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9963
MDA-MB-231 NVP-TAE684 2 625.00
2.0259
1.7158
 0.1623 0.1401 1.9799 0.8523
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9862
1.4652
2.0646
 -0.3841 -0.4528 1.8800 0.2402
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9942
MDA-MB-231 NVP-TAE684 2 1250.00
1.6884
1.4124
 0.1670 0.1518 2.0270 0.8184
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9912
1.3223
1.7108
 -0.2819 -0.3233 1.9357 0.2619
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9958
MDA-MB-231 NVP-TAE684 2 2500.00
1.7361
1.4942
 0.1953 0.0817 1.1887 0.7848
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.975
1.1268
1.6351
 -0.2484 -0.3661 1.4754 0.3087
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9809
MDA-MB-231 NVP-TAE684 2 5000.00
3.0012
2.2098
 0.2858 0.2699 2.5349 0.8689
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9982
1.7148
2.2135
 -0.4251 -0.4567 2.5415 0.2612
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9982
MDA-MB-231 PLX-4720 2 156.25
inf
inf
 0.9623 0.9623 0.0000 1.0429
flat fit: x = Einf
-1.5957
inf
inf
 0.9789 0.9789 0.0000 -0.0458
flat fit: x = Einf
-3.3141
MDA-MB-231 PLX-4720 2 312.50
inf
inf
 1.0408 1.0408 0.0000 1.0494
flat fit: x = Einf
-269.5147
inf
inf
 1.0500 1.0500 0.0000 -0.0500
flat fit: x = Einf
-inf
MDA-MB-231 PLX-4720 2 625.00
inf
inf
 0.9424 0.9424 0.0000 1.0457
flat fit: x = Einf
-0.9622
inf
inf
 0.9246 0.9246 0.0000 -0.0450
flat fit: x = Einf
-0.4498
MDA-MB-231 PLX-4720 2 1250.00
inf
inf
 0.9469 0.9469 0.0000 1.0345
flat fit: x = Einf
-0.3496
inf
inf
 0.9379 0.9379 0.0000 -0.0332
flat fit: x = Einf
-0.1825
MDA-MB-231 PLX-4720 2 2500.00
26.7083
26.6648
 0.8078 0.0041 5.0000 1.0124
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.8311
23.8837
29.7222
 0.7573 -0.9924 5.0000 -0.0118
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.8719
MDA-MB-231 PLX-4720 2 5000.00
inf
17.374
 0.8752 0.7915 2.8318 0.9946
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9176
inf
17.2229
 0.7520 0.5906 2.8688 0.0101
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9161
MDA-MB-231 Palbociclib 2 156.25
inf
inf
 0.5232 0.5232 0.0000 0.6724
flat fit: x = Einf
0.4693
inf
inf
 0.1671 0.1671 0.0000 0.5675
flat fit: x = Einf
0.4695
MDA-MB-231 Palbociclib 2 312.50
0.3967
0.0731
 0.4232 0.4460 1.3158 0.6297
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.8804
0.103
0.0852
 0.0768 0.1193 1.4383 0.5763
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.8823