Breast Cancer Cell Density: Imaging assay of the density- and context-dependence of small molecule perturbagen response in breast cancer cell lines. Dataset 3 of 3: Calculated dose-response metrics. - Dataset (ID:20258)

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Cell Small Molecule Replicate Seeding Density IC50 EC50 Emax Einf IC Hill Coefficient IC_AUC IC Curve Fit IC r2 GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR Curve Fit GR r2
MDA-MB-231 Palbociclib 2 625.00
0.4883
0.0683
 0.4179 0.4188 0.9244 0.6201
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.8976
0.1179
0.081
 0.1470 0.1436 0.9007 0.5472
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9006
MDA-MB-231 Palbociclib 2 1250.00
0.5472
0.1401
 0.3442 0.3586 0.9266 0.6330
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9685
0.2246
0.1672
 0.0908 0.1229 0.9545 0.4850
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9708
MDA-MB-231 Palbociclib 2 2500.00
0.9395
0.1288
 0.3840 0.3682 0.6710 0.6360
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9534
0.2072
0.1524
 0.1071 0.0989 0.7171 0.5061
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9595
MDA-MB-231 Palbociclib 2 5000.00
inf
0.0842
 0.6361 0.6153 0.7105 0.7592
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.946
0.193
0.084
 0.2656 0.2238 0.7137 0.4860
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9471
MDA-MB-231 Nilotinib 2 156.25
inf
inf
 1.0500 1.0500 0.0000 1.0500
flat fit: x = Einf
-inf
inf
inf
 1.0500 1.0500 0.0000 -0.0500
flat fit: x = Einf
-inf
MDA-MB-231 Nilotinib 2 312.50
inf
inf
 1.0500 1.0500 0.0000 1.0366
flat fit: x = Einf
-2.3959
inf
inf
 1.0500 1.0500 0.0000 -0.0377
flat fit: x = Einf
-1.813
MDA-MB-231 Nilotinib 2 625.00
inf
inf
 0.8634 0.8634 0.0000 1.0302
flat fit: x = Einf
-0.1493
inf
inf
 0.8202 0.8202 0.0000 -0.0256
flat fit: x = Einf
0.042
MDA-MB-231 Nilotinib 2 1250.00
inf
3.6433
 0.4695 0.5861 5.0000 0.9445
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.8831
6.3282
3.7318
 0.2967 0.4643 5.0000 0.0797
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.874
MDA-MB-231 Nilotinib 2 2500.00
5.1355
4.3087
 0.2962 0.2921 5.0000 0.8796
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9934
4.4175
4.4919
 -0.0370 -0.0435 5.0000 0.1751
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9959
MDA-MB-231 Nilotinib 2 5000.00
7.5678
5.2314
 0.3497 0.3339 2.9840 0.8851
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9889
4.4233
5.2371
 -0.2974 -0.3287 2.9917 0.2285
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9891
MDA-MB-231 Taxol 2 156.25
0.0861
0.0178
 0.3614 0.3690 0.8510 0.7131
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.8813
0.0165
0.0211
 -0.1130 -0.1125 0.8184 0.4935
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.884
MDA-MB-231 Taxol 2 312.50
0.0304
0.0094
 0.3243 0.3479 1.0141 0.6597
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9432
0.0106
0.0126
 -0.1000 -0.0862 0.9106 0.5360
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9403
MDA-MB-231 Taxol 2 625.00
0.0258
0.0073
 0.3824 0.3830 1.1475 0.6595
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9733
0.0103
0.0089
 0.0855 0.0767 1.0931 0.4904
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9725
MDA-MB-231 Taxol 2 1250.00
0.0089
0.0041
 0.3289 0.3444 1.5007 0.5894
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9833
0.0057
0.005
 0.0618 0.0772 1.3392 0.5571
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9829
MDA-MB-231 Taxol 2 2500.00
0.0126
0.0059
 0.3171 0.3457 1.5549 0.6267
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9826
0.0074
0.0072
 -0.0161 0.0202 1.3527 0.5387
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.983
MDA-MB-231 Taxol 2 5000.00
0.0554
0.0103
 0.4353 0.4658 1.5909 0.7289
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.985
0.0093
0.0102
 -0.1382 -0.0758 1.6059 0.5469
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.985
MDA-MB-231 Omipalisib 2 156.25
0.4919
0.1879
 0.3133 0.2813 0.8592 0.6805
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9497
0.1297
0.2293
 -0.2097 -0.2944 0.8125 0.5552
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9596
MDA-MB-231 Omipalisib 2 312.50
0.4478
0.2183
 0.2713 0.2704 1.0833 0.6767
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9563
0.188
0.269
 -0.2122 -0.2235 1.0314 0.5144
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9595
MDA-MB-231 Omipalisib 2 625.00
0.4107
0.2321
 0.2477 0.2139 0.9785 0.6614
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.986
0.198
0.2966
 -0.1739 -0.2401 0.9706 0.5043
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9879
MDA-MB-231 Omipalisib 2 1250.00
0.2836
0.1668
 0.2035 0.1924 0.9148 0.6166
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9964
0.16
0.2406
 -0.1910 -0.2176 0.8860 0.5272
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9973
MDA-MB-231 Omipalisib 2 2500.00
0.3493
0.2138
 0.2056 0.1372 0.6535 0.6122
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9935
0.1417
0.3649
 -0.2473 -0.4110 0.6343 0.5602
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.995
MDA-MB-231 Omipalisib 2 5000.00
1.2441
0.7148
 0.2843 0.2018 0.9325 0.7481
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9951
0.3033
0.7107
 -0.4401 -0.6057 0.9320 0.5076
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9951
MDA-MB-231 Etoposide 2 156.25
1.0497
0.551
 0.3112 0.3384 1.7522 0.7421
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9801
0.4812
0.588
 -0.2287 -0.1860 1.5779 0.4631
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9868
MDA-MB-231 Etoposide 2 312.50
0.6286
0.3441
 0.2544 0.3321 1.8111 0.7070
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9494
0.3642
0.4218
 -0.2456 -0.1227 1.4951 0.4800
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9518
MDA-MB-231 Etoposide 2 625.00
1.1336
0.6175
 0.2935 0.3126 1.6153 0.7423
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9818
0.6588
0.7154
 -0.0940 -0.0669 1.5237 0.3909
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9886