Breast Cancer Cell Density: Imaging assay of the density- and context-dependence of small molecule perturbagen response in breast cancer cell lines. Dataset 3 of 3: Calculated dose-response metrics. - Dataset (ID:20258)

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Cell Small Molecule Replicate Seeding Density IC50 EC50 Emax Einf IC Hill Coefficient IC_AUC IC Curve Fit IC r2 GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR Curve Fit GR r2
MCF7 Palbociclib 11 2500.00
0.7069
0.1128
 0.4628 0.4775 1.6899 0.7009
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9869
0.5253
0.1296
 0.4273 0.4462 1.5920 0.3080
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9873
MCF7 Palbociclib 11 5000.00
inf
0.0904
 0.5795 0.5798 1.5694 0.7435
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.989
0.5673
0.0895
 0.4732 0.4710 1.5424 0.3246
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9914
MCF7 Nilotinib 11 156.25
inf
inf
 1.0500 1.0500 0.0000 1.0408
flat fit: x = Einf
-3.7596
inf
inf
 1.0500 1.0500 0.0000 -0.0294
flat fit: x = Einf
-0.4499
MCF7 Nilotinib 11 312.50
inf
inf
 1.0500 1.0500 0.0000 1.0406
flat fit: x = Einf
-3.5614
inf
inf
 1.0500 1.0500 0.0000 -0.0314
flat fit: x = Einf
-0.938
MCF7 Nilotinib 11 625.00
inf
4.3252
 0.6928 0.8260 5.0000 0.9786
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.5716
inf
inf
 0.7668 0.7668 0.0000 0.0232
flat fit: x = Einf
0.1977
MCF7 Nilotinib 11 1250.00
inf
5.1831
 0.4990 0.5370 5.0000 0.9529
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9489
inf
5.2602
 0.5336 0.5811 5.0000 0.0417
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9317
MCF7 Nilotinib 11 2500.00
7.6166
5.5603
 0.4013 0.3963 5.0000 0.9360
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9737
7.1168
5.6539
 0.3416 0.3418 5.0000 0.0691
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9758
MCF7 Nilotinib 11 5000.00
7.8049
5.1893
 0.4267 0.4350 5.0000 0.9291
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9868
6.2487
5.5129
 0.2181 0.2327 4.9998 0.0871
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9844
MCF7 Taxol 11 156.25
0.0096
0.0041
 0.3013 0.3371 1.3363 0.5868
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9709
0.0078
0.0058
 0.1253 0.2007 1.7535 0.4713
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9495
MCF7 Taxol 11 312.50
0.0059
0.0029
 0.2492 0.3015 1.3044 0.5384
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9755
0.0064
0.0048
 0.0728 0.1541 1.2126 0.5144
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9781
MCF7 Taxol 11 625.00
0.0034
0.002
 0.2667 0.2769 1.4580 0.4894
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9847
0.004
0.0029
 0.1751 0.1838 1.3794 0.5435
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9837
MCF7 Taxol 11 1250.00
0.0041
0.0028
 0.2588 0.2863 2.2010 0.5243
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9864
0.005
0.0036
 0.1764 0.2036 1.6797 0.5038
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9812
MCF7 Taxol 11 2500.00
0.0082
0.0048
 0.2836 0.3242 1.9524 0.5988
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9871
0.0082
0.0058
 0.1584 0.2153 1.6697 0.4483
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.985
MCF7 Taxol 11 5000.00
0.0339
0.0089
 0.4313 0.4751 2.2363 0.7285
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9745
0.0198
0.0125
 0.2177 0.2649 1.6313 0.3497
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9638
MCF7 Omipalisib 11 156.25
0.0996
0.0368
 0.2849 0.3028 0.9355 0.5608
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.966
0.0587
0.0425
 0.0936 0.1173 0.8286 0.5412
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9702
MCF7 Omipalisib 11 312.50
0.0888
0.038
 0.2330 0.2258 0.7089 0.5200
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9674
0.0543
0.0513
 0.0479 0.0165 0.5733 0.5748
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.981
MCF7 Omipalisib 11 625.00
0.0701
0.0364
 0.2158 0.1825 0.6920 0.4848
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9789
0.0551
0.0513
 0.0787 0.0216 0.6241 0.5792
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.984
MCF7 Omipalisib 11 1250.00
0.072
0.031
 0.2123 0.2165 0.6736 0.4980
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9899
0.0701
0.0544
 0.0886 0.0654 0.5553 0.5421
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9893
MCF7 Omipalisib 11 2500.00
0.1509
0.05
 0.2454 0.2282 0.5517 0.5449
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9919
0.1001
0.0891
 0.0871 0.0276 0.4869 0.5187
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.989
MCF7 Omipalisib 11 5000.00
1.3852
1.0526
 0.3486 0.0423 0.3221 0.6563
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9899
0.3308
4.5346
 0.0707 -0.6352 0.3132 0.4491
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9872
SK-BR-3 NVP-TAE684 3 156.25
inf
4.9271
 0.5731 0.5606 4.9887 1.0061
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9125
inf
inf
 1.0500 1.0500 0.0000 0.0270
flat fit: x = Einf
0.0593
SK-BR-3 NVP-TAE684 3 312.50
4.7622
2.9117
 0.3823 0.3538 2.4992 0.9267
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9661
2.3024
2.809
 -0.4077 -0.4340 3.1424 0.2056
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9832
SK-BR-3 NVP-TAE684 3 625.00
3.313
2.2118
 0.3174 0.2951 2.2076 0.9016
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9797
1.6876
2.2233
 -0.3737 -0.4205 2.2138 0.2169
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9929
SK-BR-3 NVP-TAE684 3 1250.00
2.9403
1.8935
 0.3603 0.3542 2.8010 0.8788
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.979
1.6753
1.9205
 -0.2203 -0.2325 2.7952 0.2370
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9861
SK-BR-3 NVP-TAE684 3 2500.00
2.9326
1.7264
 0.4202 0.4187 3.4289 0.8876
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9927
1.5255
1.7069
 -0.2339 -0.2367 3.4496 0.2422
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9942