Breast Cancer Cell Density: Imaging assay of the density- and context-dependence of small molecule perturbagen response in breast cancer cell lines. Dataset 3 of 3: Calculated dose-response metrics. - Dataset (ID:20258)
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| Cell | Small Molecule | Replicate | Seeding Density | IC50 | EC50 | Emax | Einf | IC Hill Coefficient | IC_AUC | IC Curve Fit | IC r2 | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR Curve Fit | GR r2 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SK-BR-3 | NVP-TAE684 | 3 | 5000.00 | inf | 2.4887 | 0.5264 | 0.5226 | 3.4711 | 0.9237 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.995 | 1.9407 | 2.3019 | -0.4033 | -0.4113 | 3.5171 | 0.2382 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9933 |
| SK-BR-3 | PLX-4720 | 3 | 156.25 | inf | inf | 0.8737 | 0.8737 | 0.0000 | 1.0427 | flat fit: x = Einf | 0.2651 | inf | inf | -0.3665 | -0.3665 | 0.0000 | 0.2532 | flat fit: x = Einf | 0.0203 |
| SK-BR-3 | PLX-4720 | 3 | 312.50 | inf | inf | 0.9468 | 0.9468 | 0.0000 | 1.0296 | flat fit: x = Einf | -0.1565 | inf | inf | 0.8876 | 0.8876 | 0.0000 | -0.0253 | flat fit: x = Einf | 0.4002 |
| SK-BR-3 | PLX-4720 | 3 | 625.00 | inf | inf | 0.8971 | 0.8971 | 0.0000 | 1.0300 | flat fit: x = Einf | 0.2271 | 24.8776 | 30.9628 | 0.7963 | -0.9932 | 5.0000 | -0.0178 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.5526 |
| SK-BR-3 | PLX-4720 | 3 | 1250.00 | inf | inf | 0.9815 | 0.9815 | 0.0000 | 1.0276 | flat fit: x = Einf | -1.2255 | inf | inf | 0.9664 | 0.9664 | 0.0000 | -0.0354 | flat fit: x = Einf | -1.1061 |
| SK-BR-3 | PLX-4720 | 3 | 2500.00 | inf | inf | 0.9248 | 0.9248 | 0.0000 | 1.0265 | flat fit: x = Einf | 0.189 | inf | 19.8465 | 0.8346 | 0.6755 | 4.7428 | -0.0312 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.6183 |
| SK-BR-3 | PLX-4720 | 3 | 5000.00 | inf | inf | 0.9675 | 0.9675 | 0.0000 | 1.0080 | flat fit: x = Einf | 0.2374 | inf | 14.8978 | 0.8807 | 0.8532 | 4.9798 | -0.0143 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.5799 |
| SK-BR-3 | Palbociclib | 3 | 156.25 | inf | inf | 0.9628 | 0.9628 | 0.0000 | 0.9375 | flat fit: x = Einf | 0.0 | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.4245 | flat fit: x = Einf | 0.0 |
| SK-BR-3 | Palbociclib | 3 | 312.50 | inf | 0.0854 | 0.7608 | 0.8104 | 5.0000 | 0.8957 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.8752 | inf | 0.0849 | 0.4211 | 0.5377 | 5.0000 | 0.2665 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9039 |
| SK-BR-3 | Palbociclib | 3 | 625.00 | inf | 1.2113 | 0.5703 | 0.5135 | 0.5997 | 0.8376 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9342 | 1.2699 | 2.0443 | 0.0899 | -0.1456 | 0.5368 | 0.3473 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9624 |
| SK-BR-3 | Palbociclib | 3 | 1250.00 | inf | 1.0831 | 0.5953 | 0.4946 | 0.4580 | 0.8128 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9554 | 1.2096 | 1.1682 | 0.2133 | 0.0079 | 0.4545 | 0.3620 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9564 |
| SK-BR-3 | Palbociclib | 3 | 2500.00 | inf | 1.7065 | 0.5984 | 0.4321 | 0.3631 | 0.7980 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9217 | 0.4142 | 1.2715 | 0.0803 | -0.2559 | 0.3685 | 0.4712 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9196 |
| SK-BR-3 | Palbociclib | 3 | 5000.00 | inf | 0.4351 | 0.6310 | 0.6033 | 0.4919 | 0.8214 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9565 | 0.0872 | 0.192 | -0.2401 | -0.2667 | 0.5420 | 0.6677 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9547 |
| SK-BR-3 | Nilotinib | 3 | 156.25 | inf | inf | 1.0500 | 1.0500 | 0.0000 | 1.0500 | flat fit: x = Einf | -inf | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.2264 | flat fit: x = Einf | 0.3029 |
| SK-BR-3 | Nilotinib | 3 | 312.50 | inf | inf | 1.0500 | 1.0500 | 0.0000 | 1.0414 | flat fit: x = Einf | -4.4122 | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0384 | flat fit: x = Einf | -2.118 |
| SK-BR-3 | Nilotinib | 3 | 625.00 | inf | inf | 0.8022 | 0.8022 | 0.0000 | 1.0234 | flat fit: x = Einf | 0.0984 | inf | inf | 0.6168 | 0.6168 | 0.0000 | -0.0041 | flat fit: x = Einf | 0.3084 |
| SK-BR-3 | Nilotinib | 3 | 1250.00 | 13.6488 | 8.0249 | 0.4676 | 0.4609 | 4.8006 | 0.9689 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9696 | 8.0102 | 8.0783 | -0.0088 | -0.0210 | 4.8675 | 0.0855 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.989 |
| SK-BR-3 | Nilotinib | 3 | 2500.00 | 9.0398 | 6.8272 | 0.3818 | 0.3771 | 5.0000 | 0.9417 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.987 | 6.1251 | 6.7639 | -0.3109 | -0.3211 | 5.0000 | 0.1426 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9947 |
| SK-BR-3 | Nilotinib | 3 | 5000.00 | 8.8636 | 5.4179 | 0.4587 | 0.4573 | 4.9961 | 0.9299 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.996 | 4.4114 | 5.1117 | -0.5390 | -0.5445 | 5.0000 | 0.2044 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9966 |
| SK-BR-3 | Taxol | 3 | 156.25 | inf | 62.0538 | 0.8033 | 0.0135 | 0.3745 | 0.9462 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.5252 | inf | inf | -0.3089 | -0.3089 | 0.0000 | 0.1752 | flat fit: x = Einf | 0.3217 |
| SK-BR-3 | Taxol | 3 | 312.50 | inf | 0.0021 | 0.5373 | 0.5357 | 1.8109 | 0.6716 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9781 | 0.0018 | 0.002 | -0.0885 | -0.0914 | 1.7611 | 0.7784 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9864 |
| SK-BR-3 | Taxol | 3 | 625.00 | 0.0081 | 0.0023 | 0.4054 | 0.4109 | 1.3697 | 0.5900 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9585 | 0.0017 | 0.0022 | -0.2454 | -0.2346 | 1.3559 | 0.8618 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9639 |
| SK-BR-3 | Taxol | 3 | 1250.00 | 0.0063 | 0.003 | 0.3891 | 0.3930 | 2.0247 | 0.5934 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9883 | 0.0026 | 0.003 | -0.1913 | -0.1834 | 2.0379 | 0.7933 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9911 |
| SK-BR-3 | Taxol | 3 | 2500.00 | 0.0052 | 0.0038 | 0.3737 | 0.3896 | 4.9997 | 0.6099 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9928 | 0.0034 | 0.0038 | -0.3866 | -0.3546 | 5.0000 | 0.8702 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9944 |
| SK-BR-3 | Taxol | 3 | 5000.00 | 0.008 | 0.0052 | 0.3778 | 0.3904 | 3.4397 | 0.6341 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.999 | 0.0034 | 0.0044 | -0.7482 | -0.7303 | 3.5838 | 1.0618 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9989 |