Breast Cancer Cell Density: Imaging assay of the density- and context-dependence of small molecule perturbagen response in breast cancer cell lines. Dataset 3 of 3: Calculated dose-response metrics. - Dataset (ID:20258)

 Full screen view
Filter results: >>>>
Cell Small Molecule Replicate Seeding Density IC50 EC50 Emax Einf IC Hill Coefficient IC_AUC IC Curve Fit IC r2 GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR Curve Fit GR r2
MDA-MB-231 Etoposide 2 1250.00
0.6787
0.4119
 0.2900 0.3118 1.9568 0.7199
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9787
0.504
0.4991
 -0.0149 0.0083 1.7058 0.3927
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9851
MDA-MB-231 Etoposide 2 2500.00
0.7495
0.4396
 0.2800 0.3048 1.7630 0.7061
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9928
0.5004
0.5182
 -0.0684 -0.0292 1.6282 0.4176
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9943
MDA-MB-231 Etoposide 2 5000.00
2.4493
0.493
 0.4246 0.4434 1.3591 0.7663
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9907
0.4275
0.4946
 -0.1476 -0.1099 1.3624 0.4654
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9908
MDA-MB-231 Methotrexate 2 156.25
inf
inf
 1.0357 1.0357 0.0000 1.0491
flat fit: x = Einf
-115.8103
inf
inf
 1.0500 1.0500 0.0000 -0.0500
flat fit: x = Einf
-inf
MDA-MB-231 Methotrexate 2 312.50
inf
inf
 0.9889 0.9889 0.0000 1.0313
flat fit: x = Einf
-1.6535
inf
inf
 1.0072 1.0072 0.0000 -0.0341
flat fit: x = Einf
-1.9572
MDA-MB-231 Methotrexate 2 625.00
inf
inf
 1.0500 1.0500 0.0000 1.0425
flat fit: x = Einf
-5.9217
inf
inf
 1.0500 1.0500 0.0000 -0.0436
flat fit: x = Einf
-9.101
MDA-MB-231 Methotrexate 2 1250.00
inf
4.2927
 0.8144 0.8117 5.0000 1.0167
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.699
inf
4.2947
 0.7796 0.7763 5.0000 -0.0135
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.7691
MDA-MB-231 Methotrexate 2 2500.00
inf
3.2617
 0.5937 0.5921 5.0000 0.9741
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9559
5.1862
3.3121
 0.4491 0.4469 4.9998 0.0394
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9676
MDA-MB-231 Methotrexate 2 5000.00
56.287
6.0905
 0.6426 0.4886 1.6989 0.9544
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9977
5.8779
6.1353
 0.2779 -0.0377 1.6948 0.0919
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9977
MDA-MB-231 Lapatinib 10 156.25
11.1771
11.1749
 0.6352 0.0005 5.0000 1.0226
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.8681
10.0863
12.3724
 0.5152 -0.8886 5.0000 -0.0146
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9205
MDA-MB-231 Lapatinib 10 312.50
11.523
11.4892
 0.6689 0.0073 5.0000 1.0248
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.8438
11.0126
13.0514
 0.6509 -0.6690 5.0000 -0.0236
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.8578
MDA-MB-231 Lapatinib 10 625.00
10.8333
10.8148
 0.5980 0.0043 5.0000 1.0193
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.8914
10.5459
12.6515
 0.5888 -0.7424 5.0000 -0.0175
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.8995
MDA-MB-231 Lapatinib 10 1250.00
13.5226
12.4514
 0.7914 0.1691 5.0000 1.0271
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.6995
13.5054
12.6929
 0.7977 0.1334 4.9999 -0.0270
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.6857
MDA-MB-231 Lapatinib 10 2500.00
inf
9.6564
 0.7479 0.5250 3.5122 0.9940
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9287
29.6148
10.3631
 0.7594 0.4871 3.4860 0.0070
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9406
MDA-MB-231 Lapatinib 10 5000.00
inf
3.8171
 0.8758 0.8748 4.9921 0.9946
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9199
inf
3.8345
 0.8307 0.8293 4.9928 0.0076
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9235
MDA-MB-231 Palbociclib 10 156.25
0.5952
0.2131
 0.3587 0.4025 1.5910 0.6958
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9632
0.2968
0.2232
 0.1024 0.1839 1.6080 0.4242
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9535
MDA-MB-231 Palbociclib 10 312.50
0.745
0.3644
 0.3941 0.4273 2.6957 0.7416
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9862
0.4361
0.368
 0.2132 0.2708 4.5989 0.3318
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9772
MDA-MB-231 Palbociclib 10 625.00
0.8012
0.269
 0.3802 0.3944 1.4242 0.7124
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9899
0.4157
0.269
 0.2130 0.2411 1.5119 0.3592
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9901
MDA-MB-231 Palbociclib 10 1250.00
0.7266
0.2418
 0.3676 0.3858 1.3417 0.6853
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.967
0.3969
0.2846
 0.1601 0.2029 1.5649 0.3988
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9671
MDA-MB-231 Palbociclib 10 2500.00
1.4426
0.1738
 0.4450 0.4405 1.0053 0.6943
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9893
0.3439
0.1893
 0.2323 0.2275 1.0163 0.4143
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9876
MDA-MB-231 Palbociclib 10 5000.00
inf
0.1941
 0.5962 0.5863 1.2276 0.7723
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9831
0.2722
0.162
 0.2342 0.2205 1.1209 0.4464
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9777
MDA-MB-231 Erlotinib 10 156.25
inf
inf
 1.0437 1.0437 0.0000 1.0446
flat fit: x = Einf
-15.7065
inf
inf
 1.0475 1.0475 0.0000 -0.0446
flat fit: x = Einf
-13.1977
MDA-MB-231 Erlotinib 10 312.50
inf
inf
 0.8711 0.8711 0.0000 1.0429
flat fit: x = Einf
0.2802
inf
inf
 0.8677 0.8677 0.0000 -0.0427
flat fit: x = Einf
0.3075
MDA-MB-231 Erlotinib 10 625.00
inf
10.7336
 0.7286 0.7164 5.0000 1.0143
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.8629
inf
10.833
 0.7355 0.7230 4.9995 -0.0136
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.8631
MDA-MB-231 Erlotinib 10 1250.00
inf
15.7625
 0.7126 0.6252 4.9986 1.0256
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.8373
inf
16.616
 0.7300 0.6198 4.8290 -0.0251
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.8261