Breast Cancer Cell Density: Imaging assay of the density- and context-dependence of small molecule perturbagen response in breast cancer cell lines. Dataset 3 of 3: Calculated dose-response metrics. - Dataset - HMS LINCS Database

Breast Cancer Cell Density: Imaging assay of the density- and context-dependence of small molecule perturbagen response in breast cancer cell lines. Dataset 3 of 3: Calculated dose-response metrics. - Dataset (ID:20258)

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Cell	Small Molecule	Replicate	Seeding Density	IC50	EC50	Emax	Einf	IC Hill Coefficient	IC_AUC	IC Curve Fit	IC r2	GR50	GEC50	GRmax	GRinf	GR Hill Coefficient	GR_AOC	GR Curve Fit	GR r2
MCF7	NVP-TAE684	1	156.25	0.1519	0.0644	0.3193	0.3262	1.2302	0.6033	sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)	0.6193	0.065	0.0749	-0.1298	-0.1020	1.3170	0.6318	sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)	0.6437
MCF7	NVP-TAE684	1	312.50	0.4509	0.2457	0.2754	0.2733	1.3021	0.6976	sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)	0.9794	0.2018	0.2687	-0.2296	-0.2307	1.3254	0.5092	sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)	0.9843
MCF7	NVP-TAE684	1	625.00	0.2192	0.099	0.2678	0.2470	0.8569	0.5936	sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)	0.938	0.0695	0.1098	-0.2274	-0.2493	0.8837	0.6602	sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)	0.9391
MCF7	NVP-TAE684	1	1250.00	0.1798	0.1022	0.2463	0.2465	1.2012	0.6100	sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)	0.993	0.0842	0.1223	-0.2788	-0.2814	1.1945	0.6383	sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)	0.9948
MCF7	NVP-TAE684	1	2500.00	0.1816	0.1092	0.2284	0.2285	1.2011	0.6053	sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)	0.9869	0.0998	0.1392	-0.2196	-0.2296	1.1347	0.5990	sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)	0.9911
MCF7	NVP-TAE684	1	5000.00	0.2805	0.1563	0.2443	0.2404	1.1203	0.6418	sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)	0.9951	0.1732	0.2149	-0.1027	-0.1268	1.0475	0.4927	sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)	0.9959
MCF7	PLX-4720	1	156.25	inf	inf	1.0500	1.0500	0.0000	0.9608	flat fit: x = Einf	0.0284	inf	inf	1.0500	1.0500	0.0000	0.0701	flat fit: x = Einf	0.0392
MCF7	PLX-4720	1	312.50	inf	inf	1.0407	1.0407	0.0000	1.0433	flat fit: x = Einf	-7.967	inf	inf	1.0277	1.0277	0.0000	-0.0417	flat fit: x = Einf	-5.0111
MCF7	PLX-4720	1	625.00	inf	inf	0.9301	0.9301	0.0000	1.0366	flat fit: x = Einf	-0.2052	inf	inf	0.9279	0.9279	0.0000	-0.0383	flat fit: x = Einf	-0.2419
MCF7	PLX-4720	1	1250.00	inf	inf	0.8833	0.8833	0.0000	1.0273	flat fit: x = Einf	0.3821	25.8741	32.2082	0.8293	-0.9944	5.0000	-0.0278	sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)	0.5901
MCF7	PLX-4720	1	2500.00	inf	inf	0.8932	0.8932	0.0000	1.0260	flat fit: x = Einf	0.3153	26.6745	33.1721	0.8514	-0.9872	5.0000	-0.0235	sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)	0.5115
MCF7	PLX-4720	1	5000.00	30.4154	27.315	0.8616	0.2079	5.0000	1.0058	sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)	0.6868	27.4593	28.3756	0.8377	-0.0892	5.0000	-0.0042	sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)	0.7273
MCF7	Palbociclib	1	156.25	inf	inf	1.0500	1.0500	0.0000	0.7330	flat fit: x = Einf	0.1891	inf	inf	0.9981	0.9981	0.0000	0.4897	flat fit: x = Einf	0.2058
MCF7	Palbociclib	1	312.50	inf	0.0296	0.6310	0.6406	4.9997	0.7245	sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)	0.8126	0.0478	0.0293	0.4426	0.4563	4.9581	0.4225	sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)	0.7762
MCF7	Palbociclib	1	625.00	inf	0.0495	0.7935	0.7081	1.6495	0.7940	sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)	0.7228	0.0363	0.0274	0.6326	0.3767	4.9999	0.5066	sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)	0.5767
MCF7	Palbociclib	1	1250.00	inf	0.1193	0.5921	0.5754	2.4314	0.7296	sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)	0.9432	0.0996	0.0981	0.0619	0.0138	1.9095	0.6527	sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)	0.9143
MCF7	Palbociclib	1	2500.00	inf	0.1215	0.5333	0.5268	1.3859	0.7213	sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)	0.9651	0.1255	0.111	0.0927	0.0729	1.2862	0.5605	sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)	0.9546
MCF7	Palbociclib	1	5000.00	16.6145	0.0839	0.4902	0.4728	0.5507	0.6828	sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)	0.9227	0.4297	0.103	0.2967	0.2700	0.5435	0.4250	sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)	0.9285
MCF7	Nilotinib	1	156.25	inf	inf	1.0500	1.0500	0.0000	0.9881	flat fit: x = Einf	-0.0071	inf	inf	1.0500	1.0500	0.0000	0.0329	flat fit: x = Einf	-0.0116
MCF7	Nilotinib	1	312.50	inf	inf	1.0500	1.0500	0.0000	1.0475	flat fit: x = Einf	-65.5018	inf	inf	1.0500	1.0500	0.0000	-0.0500	flat fit: x = Einf	-inf
MCF7	Nilotinib	1	625.00	inf	inf	1.0500	1.0500	0.0000	1.0086	flat fit: x = Einf	-0.0479	inf	inf	1.0500	1.0500	0.0000	-0.0024	flat fit: x = Einf	0.0561
MCF7	Nilotinib	1	1250.00	inf	inf	0.8215	0.8215	0.0000	0.9811	flat fit: x = Einf	0.361	inf	inf	0.7629	0.7629	0.0000	0.0364	flat fit: x = Einf	0.4077
MCF7	Nilotinib	1	2500.00	inf	2.847	0.4409	0.6468	5.0000	0.9187	sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)	0.7033	6.6534	2.945	0.1877	0.4915	5.0000	0.1226	sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)	0.6917
MCF7	Nilotinib	1	5000.00	5.1123	3.8879	0.3213	0.3163	3.6574	0.8487	sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)	0.9625	3.9346	3.8451	0.0471	0.0543	5.0000	0.2007	sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)	0.9742
MCF7	Taxol	1	156.25	0.011	0.0043	0.3104	0.4024	1.7559	0.6131	sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)	0.9485	0.0041	0.0046	-0.2753	-0.0985	1.6543	0.7098	sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)	0.9333

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HMS LINCS Project

Breast Cancer Cell Density: Imaging assay of the density- and context-dependence of small molecule perturbagen response in breast cancer cell lines. Dataset 3 of 3: Calculated dose-response metrics. - Dataset (ID:20258)