PLX-4720 - Small Molecule (ID:10049-101)

HMS LINCS ID: 10049-101
Name: PLX-4720
Alternative Names:
LINCS ID: LSM-1049
PubChem CID: 24180719
ChEBI ID:
ChEMBL ID:
Molecular Mass: 413.04
InChi: InChI=1S/C17H14ClF2N3O3S/c1-2-5-27(25,26)23-13-4-3-12(19)14(15(13)20)16(24)11-8-22-17-10(11)6-9(18)7-21-17/h3-4,6-8,23H,2,5H2,1H3,(H,21,22)
InChi Key: YZDJQTHVDDOVHR-UHFFFAOYSA-N
SMILES: CCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CNC3=NC=C(C=C23)Cl)F
Relevant Citations:
Comments:
Date Publicly Available:
Most Recent Update: 2016-04-04

Target Affinity:

(see Study 20000)
Target Affinity Spectrum Value HUGO Gene Name
1
(Kd <100 nM)
FGR, MAP2K5, MAP3K20, PF3D7_0217500, PTK6, RAF1, SRMS
2
(equivalent to 100 nM ≤ Kd < 1µM)
BRAF, CDK19, EPHB6, LIMK2, MAP2K1, MAP2K4, NEK11, PDGFRA, PDGFRB, RIOK2, RIPK2, SIK1, SIK1B, TGFBR2
3
(equivalent to 1µM ≤ Kd < 10 µM)
ABL1, ABL2, ACVR2B, AIM1, AURKB, AURKC, BLK, BMPR1B, C8orf44-SGK3, CAMK1, CDK8, CLK1, CLK2, CSF1R, CSK, CSNK1G2, DCLK1, DCLK3, DDR1, DDR2, DYRK2, EIF2AK4, FES, FGFR1, FGFR2, FLG, FLT1, FLT3, FRK, FYN, HCK, HIPK1, HIPK2, HIPK3, HIPK4, KDR, KIT, LCK, LIMK1, LYN, MAP2K2, MAP4K5, MINK1, MYLK4, NEK2, OSR1, OXSR1, PAK1, PI4KB, PLK4, RIPK1, SGK3, SIK2, SLK, SRC, STK16, STK36, TESK1, TKT, TNIK, TNK2, YES1
10
(confirmed non-binding)
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Batch Information for HMSL10049-101-1:

HMS LINCS Batch ID: 10049-101-1
Provider: Nathanael Gray (DFCI)
Provider Batch ID: PLX-4720-1
Salt: 101
Molecular Formula: C17H14ClF2N3O3S
Molecular Weight: 413.83
Purity:
Purification Method:
Chemical Synthesis Reference:
Comments:
Date Publicly Available: 2011-07-15
Most Recent Update: 2016-04-04

HMS QC Testing Events for HMSL10049-101-1:

Date HMS QC Outcome Comment Files
03/13/2015 PASS HMSL10049-101-1_LCMS.pdf