Breast Cancer Cell Density: Imaging assay of the density- and context-dependence of small molecule perturbagen response in breast cancer cell lines. Dataset 3 of 3: Calculated dose-response metrics. - Dataset (ID:20258)

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Cell Small Molecule Replicate Seeding Density IC50 EC50 Emax Einf IC Hill Coefficient IC_AUC IC Curve Fit IC r2 GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR Curve Fit GR r2
BT-20 Nilotinib 5 5000.00
7.6857
6.2847
 0.3308 0.3172 5.0000 0.9219
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9916
7.7626
6.4158
 0.3174 0.3072 5.0000 0.0827
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9952
BT-20 Taxol 5 156.25
inf
0.0039
 0.5518 0.5741 5.0000 0.7328
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9728
inf
0.004
 0.5202 0.5381 5.0000 0.2937
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.966
BT-20 Taxol 5 312.50
0.0142
0.0078
 0.4488 0.4744 5.0000 0.7172
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9855
0.008
0.0079
 -0.0295 0.0195 5.0000 0.5414
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9936
BT-20 Taxol 5 625.00
0.0092
0.0061
 0.3901 0.4103 4.2096 0.6613
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9912
0.0065
0.0063
 0.0254 0.0624 4.2108 0.5407
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9939
BT-20 Taxol 5 1250.00
0.0078
0.0054
 0.3550 0.3656 3.4833 0.6209
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9911
0.006
0.0057
 0.0558 0.0741 3.4241 0.5493
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9917
BT-20 Taxol 5 2500.00
0.0079
0.0057
 0.3170 0.3371 3.4232 0.6105
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9957
0.0063
0.0061
 0.0074 0.0441 3.3739 0.5573
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9968
BT-20 Taxol 5 5000.00
0.0087
0.0061
 0.3386 0.3353 3.1122 0.6113
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9998
0.0096
0.0068
 0.3320 0.3270 3.0654 0.3862
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9998
BT-20 Omipalisib 5 156.25
0.0818
0.035
 0.2566 0.3908 1.7899 0.6275
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9279
0.1513
0.0934
 0.0666 0.1648 0.8285 0.4256
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9123
BT-20 Omipalisib 5 312.50
0.0525
0.0317
 0.2012 0.3035 1.8495 0.5552
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9694
0.0247
0.0339
 -0.5295 -0.3340 1.6078 0.8437
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9699
BT-20 Omipalisib 5 625.00
0.0326
0.0233
 0.1653 0.2657 2.2599 0.5039
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9744
0.0215
0.0271
 -0.4426 -0.2448 1.7352 0.8177
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9672
BT-20 Omipalisib 5 1250.00
0.0285
0.0201
 0.1574 0.2276 1.7560 0.4593
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9854
0.0196
0.0248
 -0.3598 -0.2143 1.5252 0.8173
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9764
BT-20 Omipalisib 5 2500.00
0.0238
0.0163
 0.1614 0.2051 1.4094 0.4212
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9886
0.0154
0.0211
 -0.3262 -0.2381 1.2417 0.8612
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9817
BT-20 Omipalisib 5 5000.00
0.0193
0.0119
 0.1731 0.2017 1.0653 0.3955
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9913
0.0244
0.0202
 0.0354 0.0802 0.9264 0.6412
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9831
BT-20 Etoposide 5 156.25
inf
2.9645
 0.5720 0.5073 1.1047 0.9003
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9183
17.4478
3.3996
 0.5011 0.4107 1.0533 0.1150
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9347
BT-20 Etoposide 5 312.50
9.4452
3.3324
 0.4243 0.4045 1.5894 0.9033
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9703
2.6099
3.3871
 -0.2014 -0.2506 1.5588 0.2306
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9905
BT-20 Etoposide 5 625.00
4.8429
1.7214
 0.3982 0.4274 1.8649 0.8702
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9689
1.9475
1.8881
 -0.0097 0.0256 1.6932 0.2308
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9824
BT-20 Etoposide 5 1250.00
2.5774
1.1925
 0.3349 0.3507 1.5679 0.8093
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9805
1.3919
1.3487
 -0.0030 0.0235 1.5264 0.2850
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9864
BT-20 Etoposide 5 2500.00
1.7441
0.8916
 0.3369 0.3280 1.5902 0.7796
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9821
1.0498
1.0242
 0.0369 0.0190 1.5670 0.3159
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.989
BT-20 Etoposide 5 5000.00
1.7203
0.8327
 0.3412 0.3345 1.5233 0.7638
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9934
2.0306
1.0283
 0.3327 0.3259 1.5501 0.2257
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.995
BT-20 Methotrexate 5 156.25
inf
inf
 0.9870 0.9870 0.0000 0.9975
flat fit: x = Einf
-0.0004
inf
inf
 0.9842 0.9842 0.0000 0.0041
flat fit: x = Einf
0.0
BT-20 Methotrexate 5 312.50
inf
inf
 1.0047 1.0047 0.0000 1.0315
flat fit: x = Einf
-1.1057
inf
inf
 0.9844 0.9844 0.0000 -0.0303
flat fit: x = Einf
-0.5134
BT-20 Methotrexate 5 625.00
inf
inf
 1.0500 1.0500 0.0000 1.0323
flat fit: x = Einf
-1.9955
inf
inf
 1.0500 1.0500 0.0000 -0.0341
flat fit: x = Einf
-1.9703
BT-20 Methotrexate 5 1250.00
inf
0.0886
 0.8085 0.8016 5.0000 0.9059
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9375
inf
0.0893
 0.7550 0.7452 5.0000 0.1221
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9411
BT-20 Methotrexate 5 2500.00
inf
0.0689
 0.5466 0.5525 5.0000 0.7493
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9814
0.0972
0.0698
 0.3949 0.4044 5.0000 0.3346
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9836
BT-20 Methotrexate 5 5000.00
0.1043
0.0762
 0.3925 0.3962 5.0000 0.6538
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9954
0.1146
0.0808
 0.4079 0.4130 5.0000 0.3321
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9962