Breast Cancer Cell Density: Imaging assay of the density- and context-dependence of small molecule perturbagen response in breast cancer cell lines. Dataset 3 of 3: Calculated dose-response metrics. - Dataset (ID:20258)
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| Cell | Small Molecule | Replicate | Seeding Density | IC50 | EC50 | Emax | Einf | IC Hill Coefficient | IC_AUC | IC Curve Fit | IC r2 | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR Curve Fit | GR r2 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | Methotrexate | 4 | 2500.00 | inf | 0.0655 | 0.5500 | 0.5450 | 3.8807 | 0.7419 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9949 | 0.1014 | 0.0673 | 0.4038 | 0.3961 | 3.8321 | 0.3420 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9958 |
| BT-20 | Methotrexate | 4 | 5000.00 | 0.0945 | 0.0605 | 0.3815 | 0.3903 | 3.4013 | 0.6390 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9963 | 0.0668 | 0.0634 | 0.0644 | 0.0806 | 3.3627 | 0.5394 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9968 |
| BT-20 | NVP-TAE684 | 5 | 156.25 | 3.7985 | 2.6064 | 0.4258 | 0.4240 | 5.0000 | 0.9299 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9594 | 3.2449 | 2.7249 | 0.2931 | 0.2912 | 5.0000 | 0.0891 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9693 |
| BT-20 | NVP-TAE684 | 5 | 312.50 | 5.378 | 3.3335 | 0.4566 | 0.4543 | 5.0000 | 0.9727 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9494 | 3.174 | 3.3315 | -0.1323 | -0.1370 | 5.0000 | 0.1004 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.987 |
| BT-20 | NVP-TAE684 | 5 | 625.00 | 3.9743 | 3.1472 | 0.3465 | 0.3443 | 5.0000 | 0.9372 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9611 | 3.0988 | 3.2295 | -0.1107 | -0.1147 | 5.0000 | 0.1251 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9783 |
| BT-20 | NVP-TAE684 | 5 | 1250.00 | 3.7887 | 2.984 | 0.3500 | 0.3485 | 4.9999 | 0.9396 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.973 | 3.1295 | 3.1 | 0.0259 | 0.0231 | 4.9994 | 0.1000 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9866 |
| BT-20 | NVP-TAE684 | 5 | 2500.00 | 3.7611 | 3.111 | 0.3085 | 0.3064 | 4.9998 | 0.9283 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9778 | 3.2264 | 3.2542 | -0.0182 | -0.0219 | 4.9998 | 0.1084 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9879 |
| BT-20 | NVP-TAE684 | 5 | 5000.00 | 6.3327 | 6.3325 | 0.3264 | 0.0000 | 1.5727 | 0.9216 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9904 | 6.9448 | 11.1325 | 0.3103 | -0.4957 | 1.4597 | 0.0739 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9948 |
| BT-20 | PLX-4720 | 5 | 156.25 | inf | inf | 0.7875 | 0.7875 | 0.0000 | 0.9796 | flat fit: x = Einf | 0.3487 | inf | inf | 0.7690 | 0.7690 | 0.0000 | 0.0264 | flat fit: x = Einf | 0.336 |
| BT-20 | PLX-4720 | 5 | 312.50 | inf | inf | 0.8739 | 0.8739 | 0.0000 | 1.0430 | flat fit: x = Einf | 0.2576 | 23.2891 | 29.0104 | 0.7281 | -0.9996 | 5.0000 | -0.0372 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.7713 |
| BT-20 | PLX-4720 | 5 | 625.00 | 27.3988 | 27.3915 | 0.8257 | 0.0007 | 5.0000 | 1.0411 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.5373 | 23.1789 | 28.869 | 0.7225 | -0.9985 | 5.0000 | -0.0370 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.7788 |
| BT-20 | PLX-4720 | 5 | 1250.00 | inf | 15.0972 | 0.7265 | 0.6594 | 4.9941 | 1.0201 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.845 | inf | 15.4385 | 0.6323 | 0.5315 | 4.9970 | -0.0159 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9025 |
| BT-20 | PLX-4720 | 5 | 2500.00 | inf | 10.7502 | 0.6837 | 0.6694 | 5.0000 | 1.0082 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.8947 | inf | 10.9052 | 0.5888 | 0.5689 | 4.9949 | -0.0018 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9308 |
| BT-20 | PLX-4720 | 5 | 5000.00 | 46.6053 | 25.4846 | 0.6752 | 0.2474 | 1.1314 | 0.9594 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9635 | 57.67 | 34.2684 | 0.7244 | 0.2208 | 1.1196 | 0.0335 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9708 |
| BT-20 | Palbociclib | 5 | 156.25 | inf | 0.1197 | 0.5598 | 0.5700 | 1.6005 | 0.7536 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9872 | inf | 0.1308 | 0.5320 | 0.5409 | 1.4099 | 0.2607 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9874 |
| BT-20 | Palbociclib | 5 | 312.50 | inf | 0.0999 | 0.5008 | 0.5361 | 5.0000 | 0.7279 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9745 | 0.1074 | 0.1007 | 0.0693 | 0.1373 | 5.0000 | 0.5138 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9769 |
| BT-20 | Palbociclib | 5 | 625.00 | 0.8801 | 0.1295 | 0.4370 | 0.4519 | 1.2217 | 0.6918 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9766 | 0.1843 | 0.1415 | 0.1103 | 0.1336 | 1.1763 | 0.4818 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.981 |
| BT-20 | Palbociclib | 5 | 1250.00 | 0.4244 | 0.119 | 0.3754 | 0.3875 | 1.1726 | 0.6514 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9687 | 0.1731 | 0.1394 | 0.0917 | 0.1058 | 1.1003 | 0.4953 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9724 |
| BT-20 | Palbociclib | 5 | 2500.00 | 0.5523 | 0.1513 | 0.3443 | 0.3204 | 0.7910 | 0.6193 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9868 | 0.1967 | 0.1849 | 0.0580 | 0.0244 | 0.8083 | 0.5265 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9865 |
| BT-20 | Palbociclib | 5 | 5000.00 | 0.5672 | 0.1172 | 0.3781 | 0.3565 | 0.7917 | 0.6185 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9828 | 0.7494 | 0.1532 | 0.3879 | 0.3730 | 0.8633 | 0.3558 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9832 |
| BT-20 | Nilotinib | 5 | 156.25 | inf | inf | 1.0500 | 1.0500 | 0.0000 | 1.0500 | flat fit: x = Einf | -inf | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0477 | flat fit: x = Einf | -78.2793 |
| BT-20 | Nilotinib | 5 | 312.50 | inf | inf | 1.0500 | 1.0500 | 0.0000 | 1.0403 | flat fit: x = Einf | -0.4641 | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0336 | flat fit: x = Einf | -0.0672 |
| BT-20 | Nilotinib | 5 | 625.00 | inf | inf | 1.0500 | 1.0500 | 0.0000 | 1.0500 | flat fit: x = Einf | -inf | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | flat fit: x = Einf | -inf |
| BT-20 | Nilotinib | 5 | 1250.00 | inf | 6.3994 | 0.5665 | 0.5494 | 5.0000 | 0.9796 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9468 | 8.3302 | 6.366 | 0.3910 | 0.3697 | 4.9997 | 0.0445 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9688 |
| BT-20 | Nilotinib | 5 | 2500.00 | 7.6378 | 5.7642 | 0.3813 | 0.3776 | 4.9997 | 0.9479 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9721 | 6.0266 | 5.7114 | 0.1175 | 0.1178 | 5.0000 | 0.0890 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9821 |