LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 11 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 1. - Dataset (ID:20248)

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Cell Small Molecule Small Mol Concentration Small Mol Conc Unit LJP Library Plate Timepoint Timepoint Unit Mean Total Cell Count Before Treatment Mean Total Cell Count After Treatment Mean Total Control Cell Count Mean Relative Cell Count Mean Normalized Growth Rate Inhibition Value
MDA-MB-231 Alpelisib
1.11
uM
LJP5
 72
hr
 868 3232 3410 0.9479 0.9465
MDA-MB-231 Alpelisib
3.33
uM
LJP5
 72
hr
 868 3000 3410 0.8798 0.8743
MDA-MB-231 Alpelisib
10
uM
LJP5
 72
hr
 868 2084 3410 0.6125 0.5592
MDA-MB-231 GDC-0980
0.04
uM
LJP5
 72
hr
 868 2446 3410 0.7182 0.6911
MDA-MB-231 GDC-0980
0.12
uM
LJP5
 72
hr
 868 2220 3410 0.6504 0.6077
MDA-MB-231 GDC-0980
0.37
uM
LJP5
 72
hr
 868 1880 3410 0.5516 0.4794
MDA-MB-231 GDC-0980
1.11
uM
LJP5
 72
hr
 868 1620 3410 0.4750 0.3711
MDA-MB-231 GDC-0980
3.33
uM
LJP5
 72
hr
 868 1526 3410 0.4470 0.3293
MDA-MB-231 GDC-0980
10
uM
LJP5
 72
hr
 868 1437 3410 0.4217 0.2909
MDA-MB-231 Mitoxantrone
0.04
uM
LJP5
 72
hr
 868 877 3410 0.2564 0.0018
MDA-MB-231 Mitoxantrone
0.04
uM
LJP6
 72
hr
 868 914 3556 0.2569 0.0248
MDA-MB-231 Mitoxantrone
0.12
uM
LJP5
 72
hr
 868 928 3410 0.2724 0.0344
MDA-MB-231 Mitoxantrone
0.12
uM
LJP6
 72
hr
 868 882 3556 0.2483 0.0079
MDA-MB-231 Mitoxantrone
0.37
uM
LJP5
 72
hr
 868 810 3410 0.2376 -0.0352
MDA-MB-231 Mitoxantrone
0.37
uM
LJP6
 72
hr
 868 827 3556 0.2332 -0.0231
MDA-MB-231 Mitoxantrone
1.11
uM
LJP5
 72
hr
 868 718 3410 0.2102 -0.0935
MDA-MB-231 Mitoxantrone
1.11
uM
LJP6
 72
hr
 868 718 3556 0.2023 -0.0887
MDA-MB-231 Mitoxantrone
3.33
uM
LJP5
 72
hr
 868 668 3410 0.1962 -0.1242
MDA-MB-231 Mitoxantrone
3.33
uM
LJP6
 72
hr
 868 645 3556 0.1813 -0.1364
MDA-MB-231 Mitoxantrone
10
uM
LJP5
 72
hr
 868 331 3410 0.0969 -0.3874
MDA-MB-231 Mitoxantrone
10
uM
LJP6
 72
hr
 868 290 3556 0.0816 -0.4170
MDA-MB-231 Radicicol
0.04
uM
LJP5
 72
hr
 868 3698 3410 1.0847 1.0835
MDA-MB-231 Radicicol
0.04
uM
LJP6
 72
hr
 868 3982 3556 1.1199 1.1137
MDA-MB-231 Radicicol
0.12
uM
LJP5
 72
hr
 868 2532 3410 0.7422 0.7180
MDA-MB-231 Radicicol
0.12
uM
LJP6
 72
hr
 868 2529 3556 0.7108 0.6902