LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 11 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 1. - Dataset (ID:20248)

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Cell Small Molecule Small Mol Concentration Small Mol Conc Unit LJP Library Plate Timepoint Timepoint Unit Mean Total Cell Count Before Treatment Mean Total Cell Count After Treatment Mean Total Control Cell Count Mean Relative Cell Count Mean Normalized Growth Rate Inhibition Value
MDA-MB-231 Momelotinib
3.33
uM
LJP5
 72
hr
 868 2047 3410 0.6007 0.5445
MDA-MB-231 Momelotinib
10
uM
LJP5
 72
hr
 868 939 3410 0.2749 0.0384
MDA-MB-231 Fedratinib
0.04
uM
LJP5
 72
hr
 868 3697 3410 1.0836 1.0820
MDA-MB-231 Fedratinib
0.12
uM
LJP5
 72
hr
 868 3410 3410 0.9987 0.9970
MDA-MB-231 Fedratinib
0.37
uM
LJP5
 72
hr
 868 3137 3410 0.9202 0.9177
MDA-MB-231 Fedratinib
1.11
uM
LJP5
 72
hr
 868 2260 3410 0.6627 0.6231
MDA-MB-231 Fedratinib
3.33
uM
LJP5
 72
hr
 868 975 3410 0.2860 0.0600
MDA-MB-231 Fedratinib
10
uM
LJP5
 72
hr
 868 618 3410 0.1819 -0.1582
MDA-MB-231 Trametinib
0.04
uM
LJP5
 72
hr
 868 1088 3410 0.3193 0.1214
MDA-MB-231 Trametinib
0.12
uM
LJP5
 72
hr
 868 1278 3410 0.3756 0.2170
MDA-MB-231 Trametinib
0.37
uM
LJP5
 72
hr
 868 1199 3410 0.3524 0.1784
MDA-MB-231 Trametinib
1.11
uM
LJP5
 72
hr
 868 1147 3410 0.3364 0.1513
MDA-MB-231 Trametinib
3.33
uM
LJP5
 72
hr
 868 1155 3410 0.3385 0.1548
MDA-MB-231 Trametinib
10
uM
LJP5
 72
hr
 868 1306 3410 0.3829 0.2291
MDA-MB-231 Omipalisib
0.04
uM
LJP6
 72
hr
 868 2095 3556 0.5898 0.5427
MDA-MB-231 Omipalisib
0.12
uM
LJP6
 72
hr
 868 1578 3556 0.4438 0.3404
MDA-MB-231 Omipalisib
0.37
uM
LJP6
 72
hr
 868 1278 3556 0.3599 0.2097
MDA-MB-231 Omipalisib
1.11
uM
LJP6
 72
hr
 868 1044 3556 0.2931 0.0926
MDA-MB-231 Omipalisib
3.33
uM
LJP6
 72
hr
 868 1030 3556 0.2889 0.0843
MDA-MB-231 Omipalisib
10
uM
LJP6
 72
hr
 868 1031 3556 0.2896 0.0849
MDA-MB-231 Buparlisib
0.04
uM
LJP5
 72
hr
 868 3829 3410 1.1223 1.1199
MDA-MB-231 Buparlisib
0.12
uM
LJP5
 72
hr
 868 3425 3410 1.0048 1.0051
MDA-MB-231 Buparlisib
0.37
uM
LJP5
 72
hr
 868 2791 3410 0.8182 0.8062
MDA-MB-231 Buparlisib
1.11
uM
LJP5
 72
hr
 868 1779 3410 0.5222 0.4388
MDA-MB-231 Buparlisib
3.33
uM
LJP5
 72
hr
 868 1135 3410 0.3333 0.1456