LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 11 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 1. - Dataset (ID:20248)

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Cell Small Molecule Small Mol Concentration Small Mol Conc Unit LJP Library Plate Timepoint Timepoint Unit Mean Total Cell Count Before Treatment Mean Total Cell Count After Treatment Mean Total Control Cell Count Mean Relative Cell Count Mean Normalized Growth Rate Inhibition Value
MDA-MB-231 Barasertib
0.04
uM
LJP5
 72
hr
 868 1420 3410 0.4166 0.2829
MDA-MB-231 Barasertib
0.12
uM
LJP5
 72
hr
 868 1279 3410 0.3758 0.2173
MDA-MB-231 Barasertib
0.37
uM
LJP5
 72
hr
 868 1244 3410 0.3654 0.2006
MDA-MB-231 Barasertib
1.11
uM
LJP5
 72
hr
 868 1221 3410 0.3589 0.1892
MDA-MB-231 Barasertib
3.33
uM
LJP5
 72
hr
 868 1209 3410 0.3553 0.1832
MDA-MB-231 Barasertib
10
uM
LJP5
 72
hr
 868 1246 3410 0.3656 0.2011
MDA-MB-231 Vemurafenib
0.04
uM
LJP5
 72
hr
 868 3240 3410 0.9507 0.9486
MDA-MB-231 Vemurafenib
0.12
uM
LJP5
 72
hr
 868 3233 3410 0.9475 0.9447
MDA-MB-231 Vemurafenib
0.37
uM
LJP5
 72
hr
 868 3247 3410 0.9525 0.9515
MDA-MB-231 Vemurafenib
1.11
uM
LJP5
 72
hr
 868 2853 3410 0.8377 0.8272
MDA-MB-231 Vemurafenib
3.33
uM
LJP5
 72
hr
 868 2762 3410 0.8105 0.7982
MDA-MB-231 Vemurafenib
10
uM
LJP5
 72
hr
 868 1762 3410 0.5167 0.4310
MDA-MB-231 Enzastaurin
0.04
uM
LJP5
 72
hr
 868 3487 3410 1.0230 1.0218
MDA-MB-231 Enzastaurin
0.12
uM
LJP5
 72
hr
 868 3419 3410 1.0028 1.0023
MDA-MB-231 Enzastaurin
0.37
uM
LJP5
 72
hr
 868 3475 3410 1.0207 1.0207
MDA-MB-231 Enzastaurin
1.11
uM
LJP5
 72
hr
 868 3538 3410 1.0392 1.0393
MDA-MB-231 Enzastaurin
3.33
uM
LJP5
 72
hr
 868 3483 3410 1.0229 1.0222
MDA-MB-231 Enzastaurin
10
uM
LJP5
 72
hr
 868 3263 3410 0.9573 0.9565
MDA-MB-231 Palbociclib
0.04
uM
LJP6
 72
hr
 868 2707 3556 0.7615 0.7494
MDA-MB-231 Palbociclib
0.12
uM
LJP6
 72
hr
 868 2338 3556 0.6583 0.6279
MDA-MB-231 Palbociclib
0.37
uM
LJP6
 72
hr
 868 1974 3556 0.5565 0.4987
MDA-MB-231 Palbociclib
1.11
uM
LJP6
 72
hr
 868 1681 3556 0.4734 0.3845
MDA-MB-231 Palbociclib
3.33
uM
LJP6
 72
hr
 868 1584 3556 0.4463 0.3439
MDA-MB-231 Palbociclib
10
uM
LJP6
 72
hr
 868 1490 3556 0.4193 0.3043
MDA-MB-231 PF562271
0.04
uM
LJP6
 72
hr
 868 3236 3556 0.9117 0.9110