LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 11 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 1. - Dataset (ID:20248)

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Cell Small Molecule Small Mol Concentration Small Mol Conc Unit LJP Library Plate Timepoint Timepoint Unit Mean Total Cell Count Before Treatment Mean Total Cell Count After Treatment Mean Total Control Cell Count Mean Relative Cell Count Mean Normalized Growth Rate Inhibition Value
MDA-MB-231 Sirolimus
3.33
uM
LJP6
 72
hr
 868 2839 3556 0.7980 0.7896
MDA-MB-231 Sirolimus
10
uM
LJP6
 72
hr
 868 2997 3556 0.8424 0.8377
MDA-MB-231 ZSTK474
0.04
uM
LJP6
 72
hr
 868 3338 3556 0.9381 0.9375
MDA-MB-231 ZSTK474
0.12
uM
LJP6
 72
hr
 868 3136 3556 0.8821 0.8804
MDA-MB-231 ZSTK474
0.37
uM
LJP6
 72
hr
 868 2729 3556 0.7678 0.7564
MDA-MB-231 ZSTK474
1.11
uM
LJP6
 72
hr
 868 2454 3556 0.6906 0.6673
MDA-MB-231 ZSTK474
3.33
uM
LJP6
 72
hr
 868 2199 3556 0.6186 0.5792
MDA-MB-231 ZSTK474
10
uM
LJP6
 72
hr
 868 1948 3556 0.5476 0.4867
MDA-MB-231 BX-912
0.04
uM
LJP5
 72
hr
 868 3067 3410 0.8984 0.8931
MDA-MB-231 BX-912
0.12
uM
LJP5
 72
hr
 868 3172 3410 0.9300 0.9276
MDA-MB-231 BX-912
0.37
uM
LJP5
 72
hr
 868 2960 3410 0.8673 0.8601
MDA-MB-231 BX-912
1.11
uM
LJP5
 72
hr
 868 1867 3410 0.5472 0.4728
MDA-MB-231 BX-912
3.33
uM
LJP5
 72
hr
 868 1451 3410 0.4254 0.2964
MDA-MB-231 BX-912
10
uM
LJP5
 72
hr
 868 1363 3410 0.3990 0.2543
MDA-MB-231 Selumetinib
0.04
uM
LJP6
 72
hr
 868 3237 3556 0.9105 0.9100
MDA-MB-231 Selumetinib
0.12
uM
LJP6
 72
hr
 868 2519 3556 0.7093 0.6893
MDA-MB-231 Selumetinib
0.37
uM
LJP6
 72
hr
 868 1974 3556 0.5549 0.4967
MDA-MB-231 Selumetinib
1.11
uM
LJP6
 72
hr
 868 1812 3556 0.5097 0.4357
MDA-MB-231 Selumetinib
3.33
uM
LJP6
 72
hr
 868 1674 3556 0.4709 0.3809
MDA-MB-231 Selumetinib
10
uM
LJP6
 72
hr
 868 1467 3556 0.4127 0.2943
MDA-MB-231 MK2206
0.04
uM
LJP6
 72
hr
 868 3488 3556 0.9804 0.9802
MDA-MB-231 MK2206
0.12
uM
LJP6
 72
hr
 868 3092 3556 0.8704 0.8677
MDA-MB-231 MK2206
0.37
uM
LJP6
 72
hr
 868 2762 3556 0.7775 0.7674
MDA-MB-231 MK2206
1.11
uM
LJP6
 72
hr
 868 2676 3556 0.7528 0.7393
MDA-MB-231 MK2206
3.33
uM
LJP6
 72
hr
 868 2585 3556 0.7262 0.7080