LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 11 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 1. - Dataset (ID:20248)
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| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Normalized Growth Rate Inhibition Value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF7 | PF477736 | 10 | uM | LJP5 | 72 | hr | 1235 | 1458 | 4267 | 0.3416 | 0.0959 |
| MCF7 | LDN-193189 | 0.04 | uM | LJP5 | 72 | hr | 1235 | 4794 | 4267 | 1.1222 | 1.1302 |
| MCF7 | LDN-193189 | 0.12 | uM | LJP5 | 72 | hr | 1235 | 4265 | 4267 | 0.9996 | 0.9994 |
| MCF7 | LDN-193189 | 0.37 | uM | LJP5 | 72 | hr | 1235 | 4630 | 4267 | 1.0850 | 1.0932 |
| MCF7 | LDN-193189 | 1.11 | uM | LJP5 | 72 | hr | 1235 | 3862 | 4267 | 0.9059 | 0.8919 |
| MCF7 | LDN-193189 | 3.33 | uM | LJP5 | 72 | hr | 1235 | 2191 | 4267 | 0.5133 | 0.3765 |
| MCF7 | LDN-193189 | 10 | uM | LJP5 | 72 | hr | 1235 | 573 | 4267 | 0.1346 | -0.3496 |
| MCF7 | PF431396 | 0.04 | uM | LJP5 | 72 | hr | 1235 | 3176 | 4267 | 0.7446 | 0.6959 |
| MCF7 | PF431396 | 0.12 | uM | LJP5 | 72 | hr | 1235 | 2184 | 4267 | 0.5122 | 0.3755 |
| MCF7 | PF431396 | 0.37 | uM | LJP5 | 72 | hr | 1235 | 1632 | 4267 | 0.3826 | 0.1684 |
| MCF7 | PF431396 | 1.11 | uM | LJP5 | 72 | hr | 1235 | 1436 | 4267 | 0.3367 | 0.0878 |
| MCF7 | PF431396 | 3.33 | uM | LJP5 | 72 | hr | 1235 | 1215 | 4267 | 0.2851 | -0.0091 |
| MCF7 | PF431396 | 10 | uM | LJP5 | 72 | hr | 1235 | 748 | 4267 | 0.1756 | -0.2447 |
| MCF7 | Celastrol | 0.04 | uM | LJP6 | 72 | hr | 1235 | 4494 | 4056 | 1.1082 | 1.1237 |
| MCF7 | Celastrol | 0.12 | uM | LJP6 | 72 | hr | 1235 | 3998 | 4056 | 0.9856 | 0.9831 |
| MCF7 | Celastrol | 0.37 | uM | LJP6 | 72 | hr | 1235 | 2047 | 4056 | 0.5045 | 0.3416 |
| MCF7 | Celastrol | 1.11 | uM | LJP6 | 72 | hr | 1235 | 1313 | 4056 | 0.3237 | 0.0359 |
| MCF7 | Celastrol | 3.33 | uM | LJP6 | 72 | hr | 1235 | 830 | 4056 | 0.2048 | -0.2071 |
| MCF7 | Celastrol | 10 | uM | LJP6 | 72 | hr | 1235 | 1051 | 4056 | 0.2589 | -0.0908 |
| MCF7 | SU11274 | 0.04 | uM | LJP5 | 72 | hr | 1235 | 4880 | 4267 | 1.1441 | 1.1561 |
| MCF7 | SU11274 | 0.12 | uM | LJP5 | 72 | hr | 1235 | 4784 | 4267 | 1.1222 | 1.1339 |
| MCF7 | SU11274 | 0.37 | uM | LJP5 | 72 | hr | 1235 | 4597 | 4267 | 1.0776 | 1.0856 |
| MCF7 | SU11274 | 1.11 | uM | LJP5 | 72 | hr | 1235 | 3896 | 4267 | 0.9132 | 0.9010 |
| MCF7 | SU11274 | 3.33 | uM | LJP5 | 72 | hr | 1235 | 3145 | 4267 | 0.7357 | 0.6820 |
| MCF7 | SU11274 | 10 | uM | LJP5 | 72 | hr | 1235 | 1576 | 4267 | 0.3693 | 0.1455 |