LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 11 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 1. - Dataset (ID:20248)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Normalized Growth Rate Inhibition Value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF7 | BI-2536 | 0.12 | uM | LJP6 | 72 | hr | 1235 | 1399 | 4056 | 0.3450 | 0.0752 |
| MCF7 | BI-2536 | 0.37 | uM | LJP6 | 72 | hr | 1235 | 1463 | 4056 | 0.3608 | 0.1037 |
| MCF7 | BI-2536 | 1.11 | uM | LJP6 | 72 | hr | 1235 | 1512 | 4056 | 0.3730 | 0.1253 |
| MCF7 | BI-2536 | 3.33 | uM | LJP6 | 72 | hr | 1235 | 1395 | 4056 | 0.3441 | 0.0735 |
| MCF7 | BI-2536 | 10 | uM | LJP6 | 72 | hr | 1235 | 934 | 4056 | 0.2307 | -0.1511 |
| MCF7 | A443654 | 0.04 | uM | LJP6 | 72 | hr | 1235 | 1024 | 4056 | 0.2524 | -0.1040 |
| MCF7 | A443654 | 0.12 | uM | LJP6 | 72 | hr | 1235 | 982 | 4056 | 0.2422 | -0.1252 |
| MCF7 | A443654 | 0.37 | uM | LJP6 | 72 | hr | 1235 | 838 | 4056 | 0.2067 | -0.2026 |
| MCF7 | A443654 | 1.11 | uM | LJP6 | 72 | hr | 1235 | 790 | 4056 | 0.1947 | -0.2296 |
| MCF7 | A443654 | 3.33 | uM | LJP6 | 72 | hr | 1235 | 584 | 4056 | 0.1442 | -0.3553 |
| MCF7 | A443654 | 10 | uM | LJP6 | 72 | hr | 1235 | 748 | 4056 | 0.1844 | -0.2546 |
| MCF7 | SB590885 | 0.04 | uM | LJP5 | 72 | hr | 1235 | 4382 | 4267 | 1.0253 | 1.0258 |
| MCF7 | SB590885 | 0.12 | uM | LJP5 | 72 | hr | 1235 | 4368 | 4267 | 1.0218 | 1.0201 |
| MCF7 | SB590885 | 0.37 | uM | LJP5 | 72 | hr | 1235 | 4641 | 4267 | 1.0866 | 1.0935 |
| MCF7 | SB590885 | 1.11 | uM | LJP5 | 72 | hr | 1235 | 4899 | 4267 | 1.1480 | 1.1604 |
| MCF7 | SB590885 | 3.33 | uM | LJP5 | 72 | hr | 1235 | 4700 | 4267 | 1.1012 | 1.1101 |
| MCF7 | SB590885 | 10 | uM | LJP5 | 72 | hr | 1235 | 2702 | 4267 | 0.6332 | 0.5486 |
| MCF7 | Pictilisib | 0.04 | uM | LJP6 | 72 | hr | 1235 | 1727 | 4056 | 0.4257 | 0.2151 |
| MCF7 | Pictilisib | 0.12 | uM | LJP6 | 72 | hr | 1235 | 1451 | 4056 | 0.3577 | 0.0979 |
| MCF7 | Pictilisib | 0.37 | uM | LJP6 | 72 | hr | 1235 | 1203 | 4056 | 0.2968 | -0.0153 |
| MCF7 | Pictilisib | 1.11 | uM | LJP6 | 72 | hr | 1235 | 1211 | 4056 | 0.2989 | -0.0112 |
| MCF7 | Pictilisib | 3.33 | uM | LJP6 | 72 | hr | 1235 | 1191 | 4056 | 0.2937 | -0.0213 |
| MCF7 | Pictilisib | 10 | uM | LJP6 | 72 | hr | 1235 | 1193 | 4056 | 0.2940 | -0.0206 |
| MCF7 | PD184352 | 0.04 | uM | LJP5 | 72 | hr | 1235 | 4127 | 4267 | 0.9665 | 0.9613 |
| MCF7 | PD184352 | 0.12 | uM | LJP5 | 72 | hr | 1235 | 3911 | 4267 | 0.9172 | 0.9059 |