LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 11 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 1. - Dataset (ID:20248)
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| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Normalized Growth Rate Inhibition Value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF7 | Canertinib | 0.04 | uM | LJP6 | 72 | hr | 1235 | 4047 | 4056 | 0.9972 | 0.9960 |
| MCF7 | Canertinib | 0.12 | uM | LJP6 | 72 | hr | 1235 | 3572 | 4056 | 0.8803 | 0.8564 |
| MCF7 | Canertinib | 0.37 | uM | LJP6 | 72 | hr | 1235 | 3194 | 4056 | 0.7873 | 0.7392 |
| MCF7 | Canertinib | 1.11 | uM | LJP6 | 72 | hr | 1235 | 2787 | 4056 | 0.6868 | 0.6056 |
| MCF7 | Canertinib | 3.33 | uM | LJP6 | 72 | hr | 1235 | 2081 | 4056 | 0.5130 | 0.3544 |
| MCF7 | Canertinib | 10 | uM | LJP6 | 72 | hr | 1235 | 430 | 4056 | 0.1061 | -0.4595 |
| MCF7 | NVP-AEW541 | 0.04 | uM | LJP5 | 72 | hr | 1235 | 4234 | 4267 | 0.9930 | 0.9926 |
| MCF7 | NVP-AEW541 | 0.12 | uM | LJP5 | 72 | hr | 1235 | 3844 | 4267 | 0.9024 | 0.8881 |
| MCF7 | NVP-AEW541 | 0.37 | uM | LJP5 | 72 | hr | 1235 | 2543 | 4267 | 0.5965 | 0.4981 |
| MCF7 | NVP-AEW541 | 1.11 | uM | LJP5 | 72 | hr | 1235 | 2156 | 4267 | 0.5052 | 0.3648 |
| MCF7 | NVP-AEW541 | 3.33 | uM | LJP5 | 72 | hr | 1235 | 2212 | 4267 | 0.5193 | 0.3860 |
| MCF7 | NVP-AEW541 | 10 | uM | LJP5 | 72 | hr | 1235 | 1048 | 4267 | 0.2461 | -0.0887 |
| MCF7 | PHA-665752 | 0.04 | uM | LJP5 | 72 | hr | 1235 | 4485 | 4267 | 1.0528 | 1.0586 |
| MCF7 | PHA-665752 | 0.12 | uM | LJP5 | 72 | hr | 1235 | 4759 | 4267 | 1.1171 | 1.1283 |
| MCF7 | PHA-665752 | 0.37 | uM | LJP5 | 72 | hr | 1235 | 4574 | 4267 | 1.0721 | 1.0796 |
| MCF7 | PHA-665752 | 1.11 | uM | LJP5 | 72 | hr | 1235 | 4218 | 4267 | 0.9893 | 0.9885 |
| MCF7 | PHA-665752 | 3.33 | uM | LJP5 | 72 | hr | 1235 | 3763 | 4267 | 0.8816 | 0.8635 |
| MCF7 | PHA-665752 | 10 | uM | LJP5 | 72 | hr | 1235 | 3029 | 4267 | 0.7105 | 0.6522 |
| MCF7 | PI103 | 0.04 | uM | LJP6 | 72 | hr | 1235 | 3469 | 4056 | 0.8555 | 0.8261 |
| MCF7 | PI103 | 0.12 | uM | LJP6 | 72 | hr | 1235 | 2471 | 4056 | 0.6094 | 0.4984 |
| MCF7 | PI103 | 0.37 | uM | LJP6 | 72 | hr | 1235 | 1540 | 4056 | 0.3799 | 0.1373 |
| MCF7 | PI103 | 1.11 | uM | LJP6 | 72 | hr | 1235 | 1223 | 4056 | 0.3018 | -0.0058 |
| MCF7 | PI103 | 3.33 | uM | LJP6 | 72 | hr | 1235 | 1148 | 4056 | 0.2829 | -0.0423 |
| MCF7 | PI103 | 10 | uM | LJP6 | 72 | hr | 1235 | 1057 | 4056 | 0.2610 | -0.0866 |
| MCF7 | Dovitinib | 0.04 | uM | LJP5 | 72 | hr | 1235 | 3846 | 4267 | 0.9011 | 0.8861 |