Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset - HMS LINCS Database

Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Small molecules	Cells	Antibodies

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Cell	Clinical Subtype	Transcriptional Subtype	Small Molecule	Antibody	Perturbagen Target	Perturbagen Class	Biological Replicate ID	Conc Unit	GR50	GEC50	GRmax	GRinf	GR Hill Coefficient	GR_AOC	GR r2	Nominal Division Rate
BT-549	TNBC	Basal B	Gemcitabine		DNA replication	DNA replication	10261.131	uM	-inf	0.00002	-0.3245	-0.3912	0.1000	1.0766	0.7849	2.3992
HCC70	TNBC	Basal A	Torkinib				15390.211	uM	-inf	0.00003	-0.9960	-0.9803	0.5245	1.8586	0.9905	0.5021
MDA-MB-436	TNBC	Basal B	Gemcitabine		DNA replication	DNA replication	10266.131	uM	-inf	0.00975	-0.9900	-1.0000	0.1117	1.3424	0.6662	0.8552
BT-474	HER2amp	Luminal	Temsirolimus		MTOR	MTOR	12291.168	uM	-inf	0.00735	-0.9999	-1.0000	0.2001	1.2788	0.8809	0.4466
MDA-MB-415	HR+	Luminal	Temsirolimus		MTOR	MTOR	12333.168	uM	-inf	0.00841	-0.9982	-1.0000	0.1818	1.2503	0.7864	0.5815
SUM1315MO2	TNBC	Basal B	Torkinib				15401.211	uM	-inf	0.00012	-0.9603	-0.8964	0.4331	1.6631	0.9588	0.4079
184A1	NM	Basal	Taxol		TUBB	TUBB	12684.002	uM	inf	0.01616	0.4397	0.5237	1.5161	0.2820	0.9561	1.5245
184A1	NM	Basal		Trastuzumab	HER2	ErbB	9047.026	uM	inf	inf	0.2837	0.2837	0.0000	0.2170	0.0804	0.5972
184A1	NM	Basal	Vinorelbine		TUBB	TUBB	7787.018	uM	inf	inf	-0.9963	-0.9963	0.0000	0.4831	0.4499	0.3791
184A1	NM	Basal	JNK-IN-5A		JNK	JNK	12509.168	uM	inf	0.95387	0.3859	0.6171	4.9990	0.1487	0.7274	1.3516
184A1	NM	Basal	PS-1145		IKK	NFKB	5895.065	uM	inf	inf	1.0031	1.0031	0.0000	-0.0389	-4.6402	1.3748
184A1	NM	Basal	Glycyl-H-1152		ROCK2		12509.169	uM	inf	inf	0.8820	0.8820	0.0000	0.0673	0.0092	1.5064
184A1	NM	Basal	FTase Inhibitor I		Ftase	MAPK	12509.167	uM	inf	inf	0.9988	0.9988	0.0000	-0.0033	-0.0009	1.4256
184A1	NM	Basal	Sirolimus		MTOR	MTOR	7787.068	uM	inf	inf	-0.2794	-0.2794	0.0000	0.5821	0.4995	0.9562
184A1	NM	Basal	Mebendazole				12684.174	uM	inf	0.36667	0.5334	0.5745	5.0000	0.1723	0.9699	1.4645
184A1	NM	Basal	PD 98059		MEK	MAPK	12509.152	uM	inf	inf	0.7622	0.7622	0.0000	0.0595	0.4482	1.3755
184A1	NM	Basal	Docetaxel		TUBB	TUBB	10002.002	uM	inf	0.00813	0.5141	0.5151	1.4431	0.2780	0.7979	0.9502
184A1	NM	Basal	Baicalein		Lipoxygenase	Metabolism	5895.073	uM	inf	35.38250	0.5990	0.5817	2.0246	0.0235	0.9408	1.4431
184A1	NM	Basal	GSK923295		CENPE	Kinesin	9047.001	uM	inf	inf	0.0385	0.0385	0.0000	0.2510	0.5226	0.7701
184A1	NM	Basal	Nilotinib		ABL	nRTK	12509.17	uM	inf	0.16976	0.8260	0.8615	1.0340	0.0781	0.8007	1.3955
184A1	NM	Basal	GM6001		MMP	MMP	5895.096	uM	inf	inf	0.9763	0.9763	0.0000	-0.0141	-0.1057	1.4232
184A1	NM	Basal	Dichloroacetate		PDK	PDK	12684.176	uM	inf	inf	0.9148	0.9148	0.0000	0.0449	0.1851	1.3650
184A1	NM	Basal	Gefitinib		EGFR	ErbB	9047.132	uM	inf	inf	0.4414	0.4414	0.0000	0.4398	0.3588	0.6985
184A1	NM	Basal	Docetaxel		TUBB	TUBB	12684.002	uM	inf	0.00450	0.5376	0.5289	1.1663	0.2796	0.9570	1.5245
184A1	NM	Basal		Cetuximab	EGFR	ErbB	7787.018	uM	inf	inf	0.4652	0.4652	0.0000	0.3838	-0.0013	0.3791

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Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)