Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR-75-1 | HR+ | Luminal | AG1478 | EGFR | ErbB | 7932.016 | uM | 175.56330 | 175.46780 | 0.5616 | 0.0014 | 4.9999 | 0.0271 | 0.7988 | 0.6446 | |
| ZR-75-1 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 11660.153 | uM | 5.40460 | 26.27890 | -0.0985 | -1.0000 | 0.6947 | 0.2579 | 0.8289 | 0.8197 | |
| ZR-75-1 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 12003.165 | uM | 5.44130 | 4.51610 | 0.1734 | 0.1126 | 1.3697 | 0.2139 | 0.8333 | 1.0267 | |
| ZR-75-1 | HR+ | Luminal | Baicalein | Lipoxygenase | Metabolism | 11660.072 | uM | 37.94840 | 712.66020 | 0.1304 | -1.0000 | 0.3746 | 0.2348 | 0.6633 | 0.9478 | |
| ZR-75-1 | HR+ | Luminal | Baicalein | Lipoxygenase | Metabolism | 7553.073 | uM | inf | 42.06410 | 0.6425 | 0.6421 | 4.8802 | 0.0551 | 0.8589 | 1.1779 | |
| ZR-75-1 | HR+ | Luminal | Baicalein | Lipoxygenase | Metabolism | 10444.072 | uM | 46.1890 | 41.34640 | 0.2094 | 0.2085 | 4.8708 | 0.1032 | 0.9321 | 0.8902 | |
| ZR-75-1 | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 14927.203 | uM | 0.01115 | 0.04208 | -0.8960 | -0.8481 | 0.7465 | 1.0346 | 0.9623 | 0.8860 | |
| ZR-75-1 | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 14927.203 | uM | 0.01115 | 0.04208 | -0.8960 | -0.8481 | 0.7465 | 1.0346 | 0.9623 | 0.8860 | |
| ZR-75-1 | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 7552.074 | uM | 0.13222 | 0.32325 | -0.7900 | -0.7103 | 0.9889 | 0.7952 | 0.9760 | 0.9174 | |
| ZR-75-1 | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 7552.074 | uM | 0.13222 | 0.32325 | -0.7900 | -0.7103 | 0.9889 | 0.7952 | 0.9760 | 0.9174 | |
| ZR-75-1 | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 7553.074 | uM | 0.11265 | 0.19850 | -0.7439 | -0.6288 | 1.4376 | 0.8537 | 0.9801 | 0.9515 | |
| ZR-75-1 | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 7553.074 | uM | 0.11265 | 0.19850 | -0.7439 | -0.6288 | 1.4376 | 0.8537 | 0.9801 | 0.9515 | |
| ZR-75-1 | HR+ | Luminal | Bosutinib | Src | nRTK | 12003.145 | uM | 25.33430 | 25.23710 | 0.0105 | 0.0095 | 4.9757 | 0.0751 | 0.9820 | 0.9611 | |
| ZR-75-1 | HR+ | Luminal | Bosutinib | Src | nRTK | 11660.145 | uM | 5.16470 | 8.72860 | -0.9838 | -0.9998 | 2.0932 | 0.4186 | 0.9930 | 0.9169 | |
| ZR-75-1 | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 12677.177 | uM | 0.10357 | 0.14167 | -0.9831 | -0.9756 | 3.4545 | 0.8644 | 0.9986 | 1.0515 | |
| ZR-75-1 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 9958.021 | uM | 39.10730 | 113.82250 | -0.9903 | -1.0000 | 1.0283 | 0.4031 | 0.9860 | 0.5129 | |
| ZR-75-1 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 7931.011 | uM | 103.88140 | 248.7080 | -0.8686 | -1.0000 | 1.2584 | 0.3024 | 0.9926 | 1.2993 | |
| ZR-75-1 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 7932.011 | uM | 78.35860 | 168.0220 | -0.9572 | -1.0000 | 1.4402 | 0.3351 | 0.9957 | 0.9025 | |
| ZR-75-1 | HR+ | Luminal | Cetuximab | EGFR | ErbB | 7932.052 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0419 | -4.4238 | 0.8877 | |
| ZR-75-1 | HR+ | Luminal | Cetuximab | EGFR | ErbB | 7931.042 | uM | inf | inf | 0.8278 | 0.8278 | 0.0000 | -0.0111 | 0.4074 | 1.3878 | |
| ZR-75-1 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 9958.034 | uM | 39.0970 | 428.03390 | -0.9912 | -1.0000 | 0.4591 | 0.4917 | 0.8402 | 0.5217 | ||
| ZR-75-1 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 7932.052 | uM | inf | 3.15490 | 0.4224 | 0.5352 | 5.0000 | 0.1701 | 0.9384 | 0.8877 | ||
| ZR-75-1 | HR+ | Luminal | Chloroquine | 12677.177 | uM | 14.34550 | 23.35810 | -0.8292 | -1.0000 | 2.2535 | 0.2823 | 0.8765 | 1.0515 | |||
| ZR-75-1 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 9958.021 | uM | 6.21370 | 19.19280 | -0.9793 | -1.0000 | 0.9741 | 0.4490 | 0.9806 | 0.5129 | |
| ZR-75-1 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 7931.017 | uM | 13.44810 | 20.36670 | -0.9048 | -0.9130 | 2.5029 | 0.3912 | 0.9927 | 1.3488 |