Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UACC-893 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 9045.001 | uM | 0.06889 | 0.07102 | -0.0282 | -0.0822 | 5.0000 | 0.5657 | 0.8819 | 0.9719 | |
| UACC-893 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 9953.001 | uM | 0.00892 | 0.00997 | -0.6091 | -0.3691 | 5.0000 | 0.8976 | 0.9020 | 0.3377 | |
| UACC-893 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 9933.001 | uM | 0.01027 | 0.01346 | -0.5736 | -0.4458 | 2.3547 | 0.9160 | 0.9093 | 0.4544 | |
| UACC-893 | HER2amp | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 9933.021 | uM | 272.40930 | 344.12690 | -0.8252 | -0.9435 | 4.5365 | 0.2252 | 0.8399 | 0.3311 | |
| UACC-893 | HER2amp | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 9045.075 | uM | 249.60140 | 314.45370 | -0.7120 | -0.8075 | 4.1618 | 0.1421 | 0.9523 | 0.8235 | |
| UACC-893 | HER2amp | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 9953.011 | uM | 163.95320 | 198.53320 | -0.7581 | -0.7646 | 4.8487 | 0.1371 | 0.9838 | 0.4697 | |
| UACC-893 | HER2amp | Luminal | Taxol | TUBB | TUBB | 9953.002 | uM | 0.04411 | 0.02816 | -0.0273 | 0.1998 | 1.1364 | 0.4530 | 0.8027 | 0.4141 | |
| UACC-893 | HER2amp | Luminal | Taxol | TUBB | TUBB | 9933.002 | uM | 0.01195 | 0.01492 | -0.7457 | -0.7313 | 4.0574 | 1.0144 | 0.9986 | 0.4305 | |
| UACC-893 | HER2amp | Luminal | Trametinib | MEK | MAPK | 9933.012 | uM | inf | inf | 0.1298 | 0.1298 | 0.0000 | 0.3783 | 0.2836 | 0.4114 | |
| UACC-893 | HER2amp | Luminal | Trametinib | MEK | MAPK | 9045.05 | uM | inf | inf | 0.6194 | 0.6194 | 0.0000 | 0.1289 | 0.2930 | 0.7910 | |
| UACC-893 | HER2amp | Luminal | Vinorelbine | TUBB | TUBB | 9045.018 | uM | 0.01175 | 0.01326 | -0.4305 | -0.4164 | 5.0000 | 0.9407 | 0.9644 | 1.0807 | |
| ZR-75-1 | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 7931.016 | uM | inf | 5.08080 | 0.6927 | 0.5471 | 0.1462 | 0.1810 | 0.5993 | 1.3152 | ||
| ZR-75-1 | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 7932.016 | uM | inf | 10.46390 | 0.5202 | 0.6389 | 5.0000 | 0.0853 | 0.6949 | 0.6446 | ||
| ZR-75-1 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 7931.04 | uM | 0.16813 | 0.17523 | -0.3062 | -0.0420 | 1.9512 | 0.4754 | 0.9530 | 1.2790 | |
| ZR-75-1 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 7932.05 | uM | 0.12828 | 0.14085 | -0.4509 | -0.2981 | 5.0000 | 0.6471 | 0.9892 | 0.8883 | |
| ZR-75-1 | HR+ | Luminal | 2-deoxyglucose | 12677.177 | uM | inf | inf | 0.3935 | 0.3935 | 0.0000 | 0.2078 | 0.3077 | 1.0515 | |||
| ZR-75-1 | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 12003.143 | uM | 3.35880 | 7.53150 | -0.1135 | -0.1557 | 0.3357 | 0.5735 | 0.8774 | 1.2499 | |
| ZR-75-1 | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 11660.143 | uM | 6.94880 | 7.04690 | -0.0033 | -0.0028 | 0.3922 | 0.5002 | 0.9612 | 1.0389 | |
| ZR-75-1 | HR+ | Luminal | 5-FU | TYMS | TYMS | 7931.017 | uM | 35.45780 | 861.00210 | -0.5462 | -1.0000 | 0.3444 | 0.6045 | 0.9796 | 1.3488 | |
| ZR-75-1 | HR+ | Luminal | 5-FU | TYMS | TYMS | 7932.017 | uM | 42.74310 | 489.33160 | -0.7143 | -1.0000 | 0.4507 | 0.6087 | 0.9805 | 1.0712 | |
| ZR-75-1 | HR+ | Luminal | Afatinib | EGFR/HER2 | ErbB | 12003.165 | uM | 2.14220 | 5.42620 | -0.9780 | -1.0000 | 1.1821 | 0.5019 | 0.9549 | 1.0267 | |
| ZR-75-1 | HR+ | Luminal | AG1024 | IGF1R | RTK | 7553.066 | uM | inf | inf | 0.8384 | 0.8384 | 0.0000 | 0.1034 | 0.2803 | 0.9707 | |
| ZR-75-1 | HR+ | Luminal | AG1024 | IGF1R | RTK | 7552.066 | uM | 31.29880 | 95.40680 | 0.4691 | -1.0000 | 0.9857 | 0.0959 | 0.7855 | 1.0180 | |
| ZR-75-1 | HR+ | Luminal | AG1024 | IGF1R | RTK | 10444.066 | uM | 26.73760 | 31.36740 | 0.0751 | -0.6106 | 4.9972 | 0.0856 | 0.9706 | 0.9196 | |
| ZR-75-1 | HR+ | Luminal | AG1478 | EGFR | ErbB | 7931.016 | uM | 984.35280 | 1000.00000 | 0.6286 | -0.0029 | 0.3646 | 0.0954 | 0.7948 | 1.3152 |