Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR75B | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 9997.024 | uM | 0.08448 | 0.0930 | -0.1253 | -0.0437 | 0.8720 | 0.5416 | 0.9774 | 0.9704 | |
| ZR75B | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 9972.012 | uM | 0.03571 | 0.03964 | -0.1050 | -0.0756 | 1.3466 | 0.6483 | 0.9968 | 1.1986 | |
| ZR75B | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 9997.011 | uM | 0.03217 | 0.01921 | 0.4132 | 0.4620 | 4.9943 | 0.3567 | 0.9393 | 1.0551 | |
| ZR75B | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 9972.011 | uM | 0.04303 | 0.03632 | 0.2284 | 0.2858 | 4.9991 | 0.4512 | 0.9803 | 0.9432 | |
| ZR75B | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 11939.16 | uM | inf | 0.28791 | 0.4831 | 0.6212 | 1.2024 | 0.1953 | 0.7098 | 1.6749 | ||
| ZR75B | HR+ | Luminal | GSK1070916 | AURK | AURK | 9997.001 | uM | 2.23530 | 37.82990 | -0.0603 | -1.0000 | 0.3884 | 0.2879 | 0.8395 | 1.0003 | |
| ZR75B | HR+ | Luminal | GSK1070916 | AURK | AURK | 9972.001 | uM | 0.74505 | 17.52730 | -0.2305 | -1.0000 | 0.3479 | 0.3511 | 0.9099 | 1.0521 | |
| ZR75B | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 7555.091 | uM | 7.21980 | 8.73030 | -0.7894 | -0.7926 | 4.9997 | 0.3470 | 0.9942 | 1.6040 | |
| ZR75B | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 7555.098 | uM | 11.90210 | 27.38920 | -0.5278 | -1.0000 | 1.3182 | 0.1866 | 0.9959 | 1.6495 | |
| ZR75B | HR+ | Luminal | GSK461364 | PLK1 | PLK | 9997.001 | uM | 0.13661 | 2.1940 | -0.6969 | -1.0000 | 0.3957 | 0.4891 | 0.8692 | 1.0003 | |
| ZR75B | HR+ | Luminal | GSK461364 | PLK1 | PLK | 9972.001 | uM | 0.06071 | 0.05479 | 0.0977 | 0.2005 | 5.0000 | 0.3759 | 0.9775 | 1.0521 | |
| ZR75B | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 9997.001 | uM | 0.04836 | 0.03537 | 0.0463 | 0.2487 | 2.1998 | 0.3757 | 0.9454 | 1.0003 | |
| ZR75B | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 9972.001 | uM | 0.08775 | 0.06887 | -0.0433 | 0.1446 | 1.4091 | 0.3949 | 0.9569 | 1.0521 | |
| ZR75B | HR+ | Luminal | Ibandronate | FDPS | 11939.143 | uM | 120.22610 | 103.64040 | 0.1901 | 0.1895 | 3.2097 | 0.1786 | 0.9863 | 1.7414 | ||
| ZR75B | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 11939.157 | uM | 0.39731 | 0.10744 | 0.4014 | 0.4355 | 1.5658 | 0.2860 | 0.9681 | 1.5908 | |
| ZR75B | HR+ | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 7555.091 | uM | 28.04830 | 43.60380 | -0.8997 | -0.9016 | 2.3362 | 0.3595 | 0.9986 | 1.6040 | |
| ZR75B | HR+ | Luminal | Ispinesib | KSP | Kinesin | 7555.067 | uM | 0.18893 | 2.06690 | -0.8416 | -1.0000 | 0.4592 | 0.5015 | 0.9134 | 1.6890 | |
| ZR75B | HR+ | Luminal | Ixabepilone | TUBB | TUBB | 7555.095 | uM | 0.22072 | 8.21350 | -0.8742 | -1.0000 | 0.3038 | 0.4763 | 0.5990 | 1.8227 | |
| ZR75B | HR+ | Luminal | JNK-IN-5A | JNK | JNK | 11939.144 | uM | 2.91330 | 2.00940 | 0.4784 | 0.4219 | 5.0000 | 0.1912 | 0.8989 | 1.6446 | |
| ZR75B | HR+ | Luminal | L-779450 | BRAF | MAPK | 11939.161 | uM | 30.47680 | 54.02740 | 0.0732 | -1.0000 | 1.9189 | 0.0857 | 0.9587 | 1.6513 | |
| ZR75B | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 7555.098 | uM | inf | inf | 0.9380 | 0.9380 | 0.0000 | 0.0155 | 0.0592 | 1.6495 | |
| ZR75B | HR+ | Luminal | LBH589 | HDAC | HDAC | 11939.154 | uM | 0.08770 | 0.17847 | -0.7416 | -0.7405 | 1.2787 | 0.7227 | 0.9983 | 1.7246 | |
| ZR75B | HR+ | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 11939.154 | uM | 0.57077 | 5.33890 | -0.5541 | -1.0000 | 0.4914 | 0.4104 | 0.9580 | 1.7246 | |
| ZR75B | HR+ | Luminal | Mebendazole | 13595.174 | uM | 0.20772 | 0.1040 | 0.2460 | 0.3358 | 1.6096 | 0.3435 | 0.9574 | 1.8596 | |||
| ZR75B | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 7555.084 | uM | inf | 0.01855 | 0.5007 | 0.5743 | 4.9998 | 0.3211 | 0.9671 | 1.7052 |