Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Cell Clinical Subtype Transcriptional Subtype Small Molecule Antibody Perturbagen Target Perturbagen Class Biological Replicate ID Conc Unit GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR r2 Nominal Division Rate
ZR75B
HR+
Luminal
Sigma A6730
AKT
AKT
11939.158
uM
1.32790
12.06410
-0.4497 -1.0000 0.4979 0.4063
0.9723
1.7251
ZR75B
HR+
Luminal
Sorafenib
PDGFR/VEGFR/KIT/FLT3
RTK
7555.084
uM
819.85330
861.47760
0.3285 -0.0865 3.2225 0.0329
0.9771
1.7052
ZR75B
HR+
Luminal
Sunitinib
PDGFR/VEGFR/KIT/FLT3
RTK
7555.067
uM
inf
inf
-0.8219 -0.8219 0.0000 0.3015
0.3753
1.6890
ZR75B
HR+
Luminal
Taxol
TUBB
TUBB
9997.002
uM
0.10845
0.04289
0.1042 0.2100 0.5873 0.3883
0.8980
0.9751
ZR75B
HR+
Luminal
Taxol
TUBB
TUBB
9972.002
uM
0.00755
0.00610
0.1087 0.1821 2.1270 0.5439
0.9847
1.0054
ZR75B
HR+
Luminal
TCS 2312
CHK1
CHK
11939.159
uM
0.99833
3.53740
-0.6582 -0.8757 0.8000 0.3337
0.9686
1.6270
ZR75B
HR+
Luminal
TCS PIM-1 1
Pim kinase
PIM
11939.135
uM
inf
1000.00000
0.7457 0.2420 0.3177 0.0891
0.6447
1.5987
ZR75B
HR+
Luminal
Temsirolimus
MTOR
MTOR
11939.144
uM
0.09396
0.06568
0.0729 0.0867 0.5320 0.5388
0.9805
1.6446
ZR75B
HR+
Luminal
Topotecan
TOP1
TOP
9997.121
uM
0.11486
1.6340
-0.8510 -1.0000 0.4138 0.7060
0.9353
1.1121
ZR75B
HR+
Luminal
Topotecan
TOP1
TOP
9972.121
uM
0.03233
0.69881
-0.8479 -1.0000 0.3575 0.8191
0.9575
1.1034
ZR75B
HR+
Luminal
Torkinib
15405.211
uM
0.00030
0.00154
-0.3164 -0.3506 0.3246 0.9816
0.9922
1.5333
ZR75B
HR+
Luminal
Tozasertib
AURK/FLT3/ABL/JAK2
AURK
11939.16
uM
0.24883
0.07353
0.2384 0.3689 1.0978 0.2938
0.9233
1.6749
ZR75B
HR+
Luminal
Trametinib
MEK
MAPK
9997.024
uM
inf
999.97430
0.6471 -0.1387 0.2260 0.1193
0.5969
0.9704
ZR75B
HR+
Luminal
Trametinib
MEK
MAPK
9972.012
uM
inf
0.02709
0.6265 0.6824 0.4873 0.1498
0.8722
1.1986
ZR75B
HR+
Luminal
Trastuzumab
HER2
ErbB
9997.026
uM
10.14060
9.03470
0.8100 0.2193 4.9983 -0.0116
0.7236
1.1348
ZR75B
HR+
Luminal
Trichostatin A
HDAC
HDAC
7555.065
uM
5.670
11.72190
-0.6834 -0.6554 1.1533 0.7880
0.9984
1.7561
ZR75B
HR+
Luminal
Triciribine
AKT
AKT
7555.074
uM
1.67260
21.85160
-0.0643 -1.0000 0.4275 0.3159
0.9482
1.6682
ZR75B
HR+
Luminal
Valproic acid
HDAC
HDAC
11939.143
uM
645.46960
1000.00000
-0.7891 -0.3543 1.2237 0.2425
0.8011
1.7414
ZR75B
HR+
Luminal
Vinorelbine
TUBB
TUBB
9972.125
uM
0.00770
0.33617
-0.9550 -1.0000 0.2910 1.0636
0.8342
1.1854
ZR75B
HR+
Luminal
Vorinostat
HDAC
HDAC
7555.065
uM
100.87210
206.42740
-0.5309 -0.5439 1.0279 0.5527
0.9943
1.7561
ZR75B
HR+
Luminal
XRP44X
ELK3
MAPK
11939.157
uM
1.36460
1.02480
0.2317 0.2281 2.1272 0.3166
0.9749
1.5908
ZR75B
HR+
Luminal
Z-Leu-Leu-Norvalinal
Proteasome
Proteasome
14149.189
uM
3.5340
4.77460
-0.1522 -0.2083 1.1576 0.2857
0.9859
2.1888
ZR75B
HR+
Luminal
ZM-447439
AURK
AURK
11939.16
uM
inf
0.38150
0.3784 0.5796 4.9967 0.1978
0.7753
1.6749