Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ZR75B | HR+ | Luminal | Sigma A6730 | AKT | AKT | 11939.158 | uM | 1.32790 | 12.06410 | -0.4497 | -1.0000 | 0.4979 | 0.4063 | 0.9723 | 1.7251 | |
ZR75B | HR+ | Luminal | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7555.084 | uM | 819.85330 | 861.47760 | 0.3285 | -0.0865 | 3.2225 | 0.0329 | 0.9771 | 1.7052 | |
ZR75B | HR+ | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7555.067 | uM | inf | inf | -0.8219 | -0.8219 | 0.0000 | 0.3015 | 0.3753 | 1.6890 | |
ZR75B | HR+ | Luminal | Taxol | TUBB | TUBB | 9997.002 | uM | 0.10845 | 0.04289 | 0.1042 | 0.2100 | 0.5873 | 0.3883 | 0.8980 | 0.9751 | |
ZR75B | HR+ | Luminal | Taxol | TUBB | TUBB | 9972.002 | uM | 0.00755 | 0.00610 | 0.1087 | 0.1821 | 2.1270 | 0.5439 | 0.9847 | 1.0054 | |
ZR75B | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 11939.159 | uM | 0.99833 | 3.53740 | -0.6582 | -0.8757 | 0.8000 | 0.3337 | 0.9686 | 1.6270 | |
ZR75B | HR+ | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 11939.135 | uM | inf | 1000.00000 | 0.7457 | 0.2420 | 0.3177 | 0.0891 | 0.6447 | 1.5987 | |
ZR75B | HR+ | Luminal | Temsirolimus | MTOR | MTOR | 11939.144 | uM | 0.09396 | 0.06568 | 0.0729 | 0.0867 | 0.5320 | 0.5388 | 0.9805 | 1.6446 | |
ZR75B | HR+ | Luminal | Topotecan | TOP1 | TOP | 9997.121 | uM | 0.11486 | 1.6340 | -0.8510 | -1.0000 | 0.4138 | 0.7060 | 0.9353 | 1.1121 | |
ZR75B | HR+ | Luminal | Topotecan | TOP1 | TOP | 9972.121 | uM | 0.03233 | 0.69881 | -0.8479 | -1.0000 | 0.3575 | 0.8191 | 0.9575 | 1.1034 | |
ZR75B | HR+ | Luminal | Torkinib | 15405.211 | uM | 0.00030 | 0.00154 | -0.3164 | -0.3506 | 0.3246 | 0.9816 | 0.9922 | 1.5333 | |||
ZR75B | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 11939.16 | uM | 0.24883 | 0.07353 | 0.2384 | 0.3689 | 1.0978 | 0.2938 | 0.9233 | 1.6749 | |
ZR75B | HR+ | Luminal | Trametinib | MEK | MAPK | 9997.024 | uM | inf | 999.97430 | 0.6471 | -0.1387 | 0.2260 | 0.1193 | 0.5969 | 0.9704 | |
ZR75B | HR+ | Luminal | Trametinib | MEK | MAPK | 9972.012 | uM | inf | 0.02709 | 0.6265 | 0.6824 | 0.4873 | 0.1498 | 0.8722 | 1.1986 | |
ZR75B | HR+ | Luminal | Trastuzumab | HER2 | ErbB | 9997.026 | uM | 10.14060 | 9.03470 | 0.8100 | 0.2193 | 4.9983 | -0.0116 | 0.7236 | 1.1348 | |
ZR75B | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 7555.065 | uM | 5.670 | 11.72190 | -0.6834 | -0.6554 | 1.1533 | 0.7880 | 0.9984 | 1.7561 | |
ZR75B | HR+ | Luminal | Triciribine | AKT | AKT | 7555.074 | uM | 1.67260 | 21.85160 | -0.0643 | -1.0000 | 0.4275 | 0.3159 | 0.9482 | 1.6682 | |
ZR75B | HR+ | Luminal | Valproic acid | HDAC | HDAC | 11939.143 | uM | 645.46960 | 1000.00000 | -0.7891 | -0.3543 | 1.2237 | 0.2425 | 0.8011 | 1.7414 | |
ZR75B | HR+ | Luminal | Vinorelbine | TUBB | TUBB | 9972.125 | uM | 0.00770 | 0.33617 | -0.9550 | -1.0000 | 0.2910 | 1.0636 | 0.8342 | 1.1854 | |
ZR75B | HR+ | Luminal | Vorinostat | HDAC | HDAC | 7555.065 | uM | 100.87210 | 206.42740 | -0.5309 | -0.5439 | 1.0279 | 0.5527 | 0.9943 | 1.7561 | |
ZR75B | HR+ | Luminal | XRP44X | ELK3 | MAPK | 11939.157 | uM | 1.36460 | 1.02480 | 0.2317 | 0.2281 | 2.1272 | 0.3166 | 0.9749 | 1.5908 | |
ZR75B | HR+ | Luminal | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 14149.189 | uM | 3.5340 | 4.77460 | -0.1522 | -0.2083 | 1.1576 | 0.2857 | 0.9859 | 2.1888 | |
ZR75B | HR+ | Luminal | ZM-447439 | AURK | AURK | 11939.16 | uM | inf | 0.38150 | 0.3784 | 0.5796 | 4.9967 | 0.1978 | 0.7753 | 1.6749 |