Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR75B | HR+ | Luminal | Cetuximab | EGFR | ErbB | 9972.125 | uM | 4.30080 | 14.18760 | 0.8594 | -0.8482 | 0.8310 | 0.0135 | 0.6892 | 1.1854 | |
| ZR75B | HR+ | Luminal | CGC-11047 | Polyamine analogue | 9997.026 | uM | 694.32460 | 1000.00000 | -0.6676 | -0.5458 | 2.0226 | 0.2645 | 0.8363 | 1.1348 | ||
| ZR75B | HR+ | Luminal | CGC-11047 | Polyamine analogue | 9972.125 | uM | 62.05340 | 1000.00000 | -0.5139 | -0.9610 | 0.3858 | 0.3920 | 0.8676 | 1.1854 | ||
| ZR75B | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 9997.049 | uM | inf | inf | 0.9585 | 0.9585 | 0.0000 | 0.0082 | 0.0001 | 1.1423 | |
| ZR75B | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 9972.017 | uM | 15.96770 | 42.6540 | -0.7631 | -1.0000 | 1.1181 | 0.2804 | 0.9966 | 1.1666 | |
| ZR75B | HR+ | Luminal | CPT-11 | TOP1 | TOP | 9997.121 | uM | 1.66170 | 0.86071 | 0.2842 | 0.3340 | 1.6759 | 0.2165 | 0.9826 | 1.1121 | |
| ZR75B | HR+ | Luminal | CPT-11 | TOP1 | TOP | 9972.121 | uM | 1.14060 | 0.77283 | 0.2080 | 0.2463 | 1.7425 | 0.2684 | 0.9929 | 1.1034 | |
| ZR75B | HR+ | Luminal | Dactolisib | PI3K | PI3K | 11939.155 | uM | 0.12564 | 0.09671 | 0.2549 | 0.2262 | 2.3010 | 0.3973 | 0.7606 | 1.6625 | |
| ZR75B | HR+ | Luminal | Dichloroacetate | PDK | PDK | 13595.176 | uM | inf | inf | 0.8559 | 0.8559 | 0.0000 | 0.0398 | 0.3144 | 1.9155 | |
| ZR75B | HR+ | Luminal | Disulfiram | Proteasome | Proteasome | 13595.174 | uM | 0.22129 | 0.11078 | 0.0054 | 0.4843 | 5.0000 | 0.2262 | 0.5901 | 1.8596 | |
| ZR75B | HR+ | Luminal | Docetaxel | TUBB | TUBB | 9972.002 | uM | 0.00317 | 0.00240 | 0.2383 | 0.2593 | 2.6193 | 0.4707 | 0.9839 | 1.0054 | |
| ZR75B | HR+ | Luminal | Docetaxel | TUBB | TUBB | 9997.002 | uM | 0.03585 | 0.01281 | 0.4029 | 0.4354 | 1.9886 | 0.2785 | 0.9894 | 0.9751 | |
| ZR75B | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 9997.121 | uM | 0.40220 | 0.87378 | -0.9219 | -0.7766 | 1.2081 | 0.6199 | 0.9828 | 1.1121 | |
| ZR75B | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 9972.121 | uM | 0.11460 | 0.30861 | -0.7860 | -0.7261 | 0.9054 | 0.7654 | 0.9839 | 1.1034 | |
| ZR75B | HR+ | Luminal | Epirubicin | TOP2 | TOP | 9972.017 | uM | 0.10999 | 0.29245 | -0.9953 | -0.7491 | 0.9363 | 0.8467 | 0.9742 | 1.1666 | |
| ZR75B | HR+ | Luminal | Erlotinib | EGFR | ErbB | 7555.091 | uM | 222.88850 | 687.59880 | 0.7916 | -0.8665 | 0.8924 | 0.0120 | 0.8409 | 1.6040 | |
| ZR75B | HR+ | Luminal | Etoposide | TOP2 | TOP | 7555.074 | uM | 1.32870 | 4.60090 | -0.0739 | -0.2956 | 0.3739 | 0.4692 | 0.9938 | 1.6682 | |
| ZR75B | HR+ | Luminal | Everolimus | MTOR | MTOR | 11939.164 | uM | 0.19830 | 5.11160 | -0.7640 | -1.0000 | 0.3381 | 0.5367 | 0.8695 | 1.6455 | |
| ZR75B | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 7555.084 | uM | 0.38730 | 0.57572 | -0.8819 | -0.8758 | 2.5533 | 0.6163 | 0.9957 | 1.7052 | |
| ZR75B | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 11939.161 | uM | 113.17760 | 580.37840 | 0.5263 | -1.0000 | 0.6721 | 0.1062 | 0.6994 | 1.6513 | |
| ZR75B | HR+ | Luminal | FTase Inhibitor I | Ftase | MAPK | 11939.154 | uM | inf | inf | 0.8647 | 0.8647 | 0.0000 | 0.0937 | 0.0531 | 1.7246 | |
| ZR75B | HR+ | Luminal | Gefitinib | EGFR | ErbB | 9997.049 | uM | inf | inf | 0.7909 | 0.7909 | 0.0000 | 0.0483 | 0.3558 | 1.1423 | |
| ZR75B | HR+ | Luminal | Gefitinib | EGFR | ErbB | 9997.024 | uM | 7.45070 | 7.79640 | -0.1265 | -0.1273 | 4.9980 | 0.1364 | 0.8935 | 0.9704 | |
| ZR75B | HR+ | Luminal | Gefitinib | EGFR | ErbB | 9972.019 | uM | 18.13440 | 23.14480 | -0.3622 | -0.7215 | 3.6614 | 0.0934 | 0.990 | 1.0654 | |
| ZR75B | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 9997.049 | uM | 0.10140 | 0.04753 | 0.1808 | 0.3301 | 1.4243 | 0.3756 | 0.8932 | 1.1423 |