Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Cell Clinical Subtype Transcriptional Subtype Small Molecule Antibody Perturbagen Target Perturbagen Class Biological Replicate ID Conc Unit GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR r2 Nominal Division Rate
ZR75B
HR+
Luminal
 Methylglyoxal
13525.184
uM
609.46450
1000.00000
 -0.8388 -0.3641 1.1049 0.3628
0.8593
 1.7478
ZR75B
HR+
Luminal
 MG-132
Proteasome
Proteasome
14149.189
uM
2.24770
2.11580
 -0.1058 0.0924 3.3807 0.2949
0.9239
 2.1888
ZR75B
HR+
Luminal
 MG-132
Proteasome
Proteasome
14149.189
uM
2.24770
2.11580
 -0.1058 0.0924 3.3807 0.2949
0.9239
 2.1888
ZR75B
HR+
Luminal
 MG-132
Proteasome
Proteasome
11939.145
uM
0.43731
0.93583
 -0.7857 -0.7902 1.2460 0.6176
0.9970
 1.6830
ZR75B
HR+
Luminal
 MG-132
Proteasome
Proteasome
11939.145
uM
0.43731
0.93583
 -0.7857 -0.7902 1.2460 0.6176
0.9970
 1.6830
ZR75B
HR+
Luminal
 Pevonedistat
NAE1
NAE1
11939.135
uM
inf
0.11569
 0.4380 0.5233 4.9998 0.2521
0.8397
 1.5987
ZR75B
HR+
Luminal
 Nelfinavir
13595.174
uM
8.11640
17.53830
 -0.4322 -1.0000 1.4258 0.1643
0.9967
 1.8596
ZR75B
HR+
Luminal
 Nilotinib
ABL
nRTK
11939.145
uM
inf
inf
 0.9109 0.9109 0.0000 0.0508
0.0110
 1.6830
ZR75B
HR+
Luminal
 NSC 663284
CDC25
CDC
11939.159
uM
5.11280
6.24970
 -0.8656 -0.8645 5.0000 0.4930
0.9990
 1.6270
ZR75B
HR+
Luminal
 NU6102
CDK1/2
CDK
11939.147
uM
16.16020
26.60070
 -0.2441 -0.5569 1.5018 0.1555
0.9891
 1.6102
ZR75B
HR+
Luminal
 Nutlin 3a
MDM2
MDM2
7555.066
uM
2.310
2.17070
 0.0678 0.0312 1.0363 0.2882
0.9823
 1.7081
ZR75B
HR+
Luminal
 Olomoucine II
CDK1
CDK
11939.147
uM
6.45430
6.82060
 -0.2828 -0.1589 5.0000 0.2506
0.9812
 1.6102
ZR75B
HR+
Luminal
 Omipalisib
PI3K
PI3K
7555.086
uM
0.00574
0.00917
 -0.2595 -0.2589 0.8890 0.8062
0.9953
 1.6344
ZR75B
HR+
Luminal
 Oxaliplatin
DNA cross-linker
DNA cross-linker
9972.011
uM
2.95190
17.1170
 -0.8648 -1.0000 0.6251 0.5673
0.9554
 0.9432
ZR75B
HR+
Luminal
 Oxaliplatin
DNA cross-linker
DNA cross-linker
9997.011
uM
2.57590
22.18760
 -0.7360 -1.0000 0.5102 0.5453
0.9593
 1.0551
ZR75B
HR+
Luminal
 Oxamflatin
HDAC
HDAC
11939.147
uM
0.44821
1.78520
 -0.8695 -1.0000 0.7949 0.6066
0.9938
 1.6102
ZR75B
HR+
Luminal
 PD 98059
MEK
MAPK
11939.159
uM
98.72460
453.86640
 0.4964 -0.9981 0.7194 0.0844
0.9176
 1.6270
ZR75B
HR+
Luminal
 PD184352
MEK
MAPK
11939.155
uM
inf
inf
 0.8123 0.8123 0.0000 0.0872
0.1864
 1.6625
ZR75B
HR+
Luminal
 PD184352
MEK
MAPK
11939.155
uM
inf
inf
 0.8123 0.8123 0.0000 0.0872
0.1864
 1.6625
ZR75B
HR+
Luminal
 Pemetrexed
TYMS/DHFR/GARFT
TYMS
7555.095
uM
inf
0.05567
 0.6026 0.5837 4.9754 0.3508
0.9533
 1.8227
ZR75B
HR+
Luminal
 PS-1145
IKK
NFKB
7555.065
uM
inf
inf
 1.0207 1.0207 0.0000 0.0155
0.0000
 1.7561
ZR75B
HR+
Luminal
 Purvalanol A
CDK1
CDK
7555.067
uM
inf
inf
 0.9271 0.9271 0.0000 0.0501
0.4768
 1.6890
ZR75B
HR+
Luminal
 Ribavirin
15405.211
uM
inf
inf
 0.4764 0.4764 0.0000 0.1513
0.5573
 1.5333
ZR75B
HR+
Luminal
 SB-3CT
MMP2/9
MMP
11939.144
uM
29.41950
23.32080
 0.3378 0.3372 4.8296 0.1011
0.9481
 1.6446
ZR75B
HR+
Luminal
 Selumetinib
MEK
MAPK
11939.155
uM
inf
0.07910
 0.7920 0.8167 1.0341 0.0915
0.8147
 1.6625