Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UACC-812 | HER2amp | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 10151.021 | uM | 7.84270 | 16.49440 | -0.9996 | -0.9978 | 1.4758 | 0.6545 | 0.9947 | 0.3048 | |
| UACC-812 | HER2amp | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 9913.021 | uM | 15.04560 | 28.39240 | -0.9991 | -0.9985 | 1.7285 | 0.5727 | 0.9973 | 0.3401 | |
| UACC-812 | HER2amp | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 10150.021 | uM | 14.6250 | 28.67070 | -0.9960 | -1.0000 | 1.6321 | 0.5811 | 0.9975 | 0.4883 | |
| UACC-812 | HER2amp | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 10267.011 | uM | 17.91380 | 29.76780 | -0.9985 | -1.0000 | 2.1632 | 0.5679 | 0.9981 | 0.3592 | |
| UACC-812 | HER2amp | Luminal | Celecoxib | COX2 | COX | 10580.136 | uM | inf | inf | 0.9217 | 0.9217 | 0.0000 | 0.1643 | 0.0000 | 0.7205 | |
| UACC-812 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 10267.026 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0438 | -8.1346 | 0.3125 | |
| UACC-812 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 7926.018 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0053 | -0.0007 | 1.0502 | |
| UACC-812 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 10151.034 | uM | 2.57870 | 64.17660 | -1.0000 | -1.0000 | 0.3418 | 0.7599 | 0.7768 | 0.3226 | ||
| UACC-812 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 10267.026 | uM | 15.170 | 207.56150 | -0.9994 | -1.0000 | 0.4199 | 0.5813 | 0.7864 | 0.3125 | ||
| UACC-812 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 10150.034 | uM | 13.75530 | 200.38140 | -0.9999 | -1.0000 | 0.4101 | 0.5854 | 0.8160 | 0.3592 | ||
| UACC-812 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 7926.018 | uM | 156.140 | 1000.00000 | -0.7276 | -1.0000 | 0.5916 | 0.3582 | 0.8356 | 1.0502 | ||
| UACC-812 | HER2amp | Luminal | Chk2 inhibitor II | CHK2 | CHK | 10580.14 | uM | inf | inf | 0.8462 | 0.8462 | 0.0000 | 0.1345 | -0.2042 | 0.8679 | |
| UACC-812 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 9913.021 | uM | 2.17820 | 5.75040 | -0.9999 | -1.0000 | 1.1317 | 0.6849 | 0.9197 | 0.3401 | |
| UACC-812 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 10150.021 | uM | 2.80010 | 7.40680 | -0.9974 | -1.0000 | 1.1294 | 0.6039 | 0.9592 | 0.4883 | |
| UACC-812 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 10151.021 | uM | 3.19650 | 5.62320 | -1.0000 | -1.0000 | 1.9450 | 0.6339 | 0.9669 | 0.3048 | |
| UACC-812 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 10267.131 | uM | 3.40290 | 6.11470 | -0.9982 | -1.0000 | 1.8746 | 0.5978 | 0.9920 | 0.3849 | |
| UACC-812 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 7926.017 | uM | 6.6620 | 15.10820 | -0.8675 | -0.9467 | 1.2975 | 0.4286 | 0.9932 | 0.8896 | |
| UACC-812 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 10151.034 | uM | 2.18960 | 2.47240 | -0.6914 | -0.4143 | 4.9682 | 0.3383 | 0.9554 | 0.3226 | |
| UACC-812 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 10150.034 | uM | 1.5260 | 1.67730 | -0.4657 | -0.3021 | 5.0000 | 0.3533 | 0.9802 | 0.3592 | |
| UACC-812 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 7926.077 | uM | 13.7090 | 17.18460 | -0.0903 | -0.1951 | 1.4580 | 0.1287 | 0.9892 | 0.8161 | |
| UACC-812 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 10267.121 | uM | 3.19510 | 4.65520 | -0.5391 | -0.5171 | 1.8867 | 0.3060 | 0.9938 | 0.4135 | |
| UACC-812 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 11938.155 | uM | 0.07951 | 0.08680 | -0.1947 | -0.1225 | 2.4982 | 0.6577 | 0.6071 | 0.6903 | |
| UACC-812 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 10754.146 | uM | 62.39660 | 388.17760 | 0.6208 | -0.9997 | 0.6009 | 0.0366 | 0.8691 | 1.2483 | |
| UACC-812 | HER2amp | Luminal | Dichloroacetate | PDK | PDK | 13078.176 | uM | inf | inf | 0.9053 | 0.9053 | 0.0000 | 0.0862 | -0.1229 | 0.7179 | |
| UACC-812 | HER2amp | Luminal | Disulfiram | Proteasome | Proteasome | 13078.174 | uM | 0.08364 | 0.09567 | -0.3146 | -0.4793 | 5.0000 | 0.8051 | 0.9537 | 0.6238 |