Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UACC-812 | HER2amp | Luminal | Docetaxel | TUBB | TUBB | 9913.002 | uM | 0.00368 | 0.00315 | 0.2367 | 0.1420 | 2.1296 | 0.5464 | 0.9437 | 0.6723 | |
| UACC-812 | HER2amp | Luminal | Docetaxel | TUBB | TUBB | 10150.002 | uM | 0.00201 | 0.00235 | -0.0289 | -0.1601 | 1.7981 | 0.7583 | 0.9645 | 0.4064 | |
| UACC-812 | HER2amp | Luminal | Docetaxel | TUBB | TUBB | 10267.002 | uM | 0.00408 | 0.00445 | -0.2526 | -0.2764 | 5.0000 | 0.7526 | 0.9798 | 0.4069 | |
| UACC-812 | HER2amp | Luminal | Docetaxel | TUBB | TUBB | 13078.002 | uM | 0.00611 | 0.00694 | -0.2021 | -0.1859 | 2.4623 | 0.6770 | 0.9935 | 0.6437 | |
| UACC-812 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 10151.034 | uM | 0.04740 | 0.10608 | -1.0000 | -1.0000 | 1.3638 | 1.0938 | 0.9616 | 0.3226 | |
| UACC-812 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 7926.077 | uM | 0.13097 | 0.26291 | -0.8866 | -0.6444 | 1.1883 | 0.7353 | 0.9686 | 0.8161 | |
| UACC-812 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 10267.121 | uM | 0.05653 | 0.16423 | -0.9987 | -0.9927 | 1.0256 | 0.9621 | 0.9948 | 0.4135 | |
| UACC-812 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 10150.034 | uM | 0.07229 | 0.14759 | -1.0000 | -0.9957 | 1.5353 | 0.9787 | 0.9986 | 0.3592 | |
| UACC-812 | HER2amp | Luminal | Epirubicin | TOP2 | TOP | 7926.017 | uM | 0.26465 | 0.28273 | -0.4007 | -0.1958 | 5.0000 | 0.6961 | 0.6364 | 0.8896 | |
| UACC-812 | HER2amp | Luminal | Erlotinib | EGFR | ErbB | 7547.092 | uM | 7.19880 | 47.08160 | 0.0191 | -1.0000 | 0.5850 | 0.2581 | 0.6012 | 0.9866 | |
| UACC-812 | HER2amp | Luminal | Everolimus | MTOR | MTOR | 11938.164 | uM | 0.02031 | 0.19751 | -0.1389 | -0.3048 | 0.2092 | 0.6096 | 0.8503 | 0.7111 | |
| UACC-812 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 11938.161 | uM | inf | inf | 0.4028 | 0.4028 | 0.0000 | 0.2922 | -0.0510 | 0.7388 | |
| UACC-812 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 10580.137 | uM | inf | inf | 0.5974 | 0.5974 | 0.0000 | 0.1466 | 0.4745 | 0.8535 | |
| UACC-812 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 10754.149 | uM | 31.66270 | 61.84540 | 0.4861 | -0.3743 | 0.8347 | 0.0862 | 0.8570 | 1.3535 | |
| UACC-812 | HER2amp | Luminal | FTase Inhibitor I | Ftase | MAPK | 11938.154 | uM | inf | inf | 0.6788 | 0.6788 | 0.0000 | 0.2133 | -0.0874 | 0.6375 | |
| UACC-812 | HER2amp | Luminal | FTase Inhibitor I | Ftase | MAPK | 10580.142 | uM | inf | inf | 0.7446 | 0.7446 | 0.0000 | 0.0399 | 0.5308 | 0.8039 | |
| UACC-812 | HER2amp | Luminal | FTase Inhibitor I | Ftase | MAPK | 10754.154 | uM | 45.78120 | 73.31260 | 0.7254 | -1.0000 | 2.3332 | 0.0513 | 0.6570 | 1.3934 | |
| UACC-812 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 9913.012 | uM | 0.01102 | 0.01431 | -0.5839 | -0.5468 | 2.8303 | 1.0517 | 0.9980 | 0.6364 | |
| UACC-812 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 10151.012 | uM | 0.00761 | 0.01304 | -0.8849 | -0.8757 | 1.8792 | 1.2907 | 0.9984 | 0.3572 | |
| UACC-812 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 10150.012 | uM | 0.02042 | 0.02445 | -0.7512 | -0.7308 | 4.9997 | 1.1335 | 0.9985 | 0.4611 | |
| UACC-812 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 10267.131 | uM | inf | inf | -0.8066 | -0.8066 | 0.0000 | 1.7801 | 0.1971 | 0.3849 | |
| UACC-812 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 10267.011 | uM | 0.04535 | 0.05545 | -0.8887 | -0.8671 | 4.9991 | 1.1102 | 0.9988 | 0.3592 | |
| UACC-812 | HER2amp | Luminal | Glycyl-H-1152 | ROCK2 | 11938.16 | uM | inf | inf | 0.9148 | 0.9148 | 0.0000 | 0.1264 | 0.0685 | 0.6405 | ||
| UACC-812 | HER2amp | Luminal | Glycyl-H-1152 | ROCK2 | 10580.138 | uM | 40.36280 | 999.84770 | 0.4908 | -0.5077 | 0.2184 | 0.1997 | 0.7854 | 0.9584 | ||
| UACC-812 | HER2amp | Luminal | Glycyl-H-1152 | ROCK2 | 10754.15 | uM | 10.6930 | 6.26750 | 0.3450 | 0.1408 | 0.6189 | 0.1518 | 0.8661 | 1.1628 |