Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR-75-1 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 7932.017 | uM | 10.07150 | 18.02160 | -0.8999 | -0.9278 | 1.8033 | 0.4331 | 0.9931 | 1.0712 | |
| ZR-75-1 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 7931.007 | uM | 7.43960 | 8.97480 | 0.1046 | -0.0745 | 0.7406 | 0.1881 | 0.9896 | 1.4557 | |
| ZR-75-1 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 7932.043 | uM | 3.46650 | 5.74850 | -0.2843 | -0.3525 | 1.0549 | 0.2509 | 0.9925 | 0.9982 | |
| ZR-75-1 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 9958.034 | uM | 0.91950 | 2.6370 | -0.6984 | -0.7804 | 0.8925 | 0.4693 | 0.9961 | 0.5217 | |
| ZR-75-1 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 11660.146 | uM | inf | inf | 0.7398 | 0.7398 | 0.0000 | 0.2031 | 0.3079 | 0.9684 | |
| ZR-75-1 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 12003.155 | uM | 0.11881 | 0.02218 | 0.4333 | 0.3944 | 0.9264 | 0.3730 | 0.6291 | 1.1249 | |
| ZR-75-1 | HR+ | Luminal | Dichloroacetate | PDK | PDK | 12677.176 | uM | inf | inf | 0.7705 | 0.7705 | 0.0000 | 0.0825 | 0.4272 | 0.9376 | |
| ZR-75-1 | HR+ | Luminal | Disulfiram | Proteasome | Proteasome | 12677.174 | uM | 0.04868 | 0.03196 | 0.4240 | 0.4390 | 5.0000 | 0.3391 | 0.6080 | 0.9992 | |
| ZR-75-1 | HR+ | Luminal | Docetaxel | TUBB | TUBB | 7932.002 | uM | 0.02764 | 0.00527 | 0.4929 | 0.4679 | 1.6551 | 0.2991 | 0.9428 | 0.8992 | |
| ZR-75-1 | HR+ | Luminal | Docetaxel | TUBB | TUBB | 9958.002 | uM | 0.00820 | 0.00391 | 0.2081 | 0.3160 | 1.3506 | 0.4063 | 0.9652 | 0.5113 | |
| ZR-75-1 | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 9958.034 | uM | 0.03555 | 0.08501 | -0.9997 | -0.5843 | 0.8879 | 0.8231 | 0.9167 | 0.5217 | |
| ZR-75-1 | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 7931.007 | uM | 0.18587 | 1.63760 | -0.6773 | -0.7919 | 0.4363 | 0.5803 | 0.9436 | 1.4557 | |
| ZR-75-1 | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 7932.043 | uM | 0.12271 | 0.25988 | -0.7083 | -0.5033 | 0.9281 | 0.6673 | 0.9471 | 0.9982 | |
| ZR-75-1 | HR+ | Luminal | Epirubicin | TOP2 | TOP | 7931.017 | uM | 0.30996 | 3.43680 | -0.9634 | -1.0000 | 0.4566 | 0.6270 | 0.8953 | 1.3488 | |
| ZR-75-1 | HR+ | Luminal | Epirubicin | TOP2 | TOP | 7932.017 | uM | 0.22602 | 0.25841 | -0.9909 | -0.4768 | 5.0000 | 0.7307 | 0.9014 | 1.0712 | |
| ZR-75-1 | HR+ | Luminal | Erlotinib | EGFR | ErbB | 7553.091 | uM | inf | inf | 0.9665 | 0.9665 | 0.0000 | -0.0228 | -0.3323 | 0.9738 | |
| ZR-75-1 | HR+ | Luminal | Etoposide | TOP2 | TOP | 7553.074 | uM | 2.04560 | 7.01310 | -0.4013 | -0.5183 | 0.5773 | 0.4802 | 0.9831 | 0.9515 | |
| ZR-75-1 | HR+ | Luminal | Etoposide | TOP2 | TOP | 7552.074 | uM | 1.85260 | 5.54480 | -0.4465 | -0.5092 | 0.6406 | 0.4842 | 0.9913 | 0.9174 | |
| ZR-75-1 | HR+ | Luminal | Everolimus | MTOR | MTOR | 12003.164 | uM | 0.02561 | 0.03003 | -0.1277 | -0.0475 | 0.5701 | 0.6142 | 0.9704 | 0.9505 | |
| ZR-75-1 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 7552.084 | uM | 0.31911 | 0.48962 | -0.9725 | -0.9736 | 2.5248 | 0.6601 | 0.9969 | 1.1307 | |
| ZR-75-1 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 7553.085 | uM | 0.35299 | 0.58389 | -0.9753 | -0.9726 | 2.1463 | 0.6085 | 0.9994 | 1.1198 | |
| ZR-75-1 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 11660.149 | uM | inf | inf | 0.7903 | 0.7903 | 0.0000 | 0.1532 | 0.0592 | 1.0690 | |
| ZR-75-1 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 12003.166 | uM | 1.95110 | 169.06310 | -0.0471 | -1.0000 | 0.2462 | 0.3907 | 0.7596 | 1.0782 | |
| ZR-75-1 | HR+ | Luminal | FTase Inhibitor I | Ftase | MAPK | 11660.154 | uM | inf | inf | 0.8493 | 0.8493 | 0.0000 | 0.1199 | -0.0998 | 0.9388 | |
| ZR-75-1 | HR+ | Luminal | FTase Inhibitor I | Ftase | MAPK | 12003.167 | uM | inf | inf | 0.7304 | 0.7304 | 0.0000 | 0.2250 | -0.0343 | 1.1158 |