Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR-75-1 | HR+ | Luminal | Gefitinib | EGFR | ErbB | 7931.016 | uM | 81.61130 | 655.20850 | 0.6483 | -0.9996 | 0.5273 | 0.0694 | 0.9347 | 1.3152 | |
| ZR-75-1 | HR+ | Luminal | Gefitinib | EGFR | ErbB | 7932.016 | uM | 29.69750 | 34.36870 | 0.2913 | -0.5380 | 5.0000 | 0.0193 | 0.960 | 0.6446 | |
| ZR-75-1 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 7931.04 | uM | 0.12349 | 0.12268 | -0.0219 | 0.0163 | 5.0000 | 0.5033 | 0.9942 | 1.2790 | |
| ZR-75-1 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 9958.012 | uM | 0.05477 | 0.06902 | -0.3984 | -0.3592 | 2.3412 | 0.7512 | 0.9975 | 0.5705 | |
| ZR-75-1 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 7932.011 | uM | 0.02338 | 0.02080 | -0.0531 | 0.1219 | 2.3909 | 0.5838 | 0.9535 | 0.9025 | |
| ZR-75-1 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 7931.011 | uM | 0.05667 | 0.02512 | 0.3168 | 0.4236 | 2.3080 | 0.3854 | 0.9628 | 1.2993 | |
| ZR-75-1 | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 12003.169 | uM | inf | inf | 0.7172 | 0.7172 | 0.0000 | 0.1350 | 0.4074 | 1.0562 | ||
| ZR-75-1 | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 11660.15 | uM | 12.39430 | 999.99110 | 0.4393 | -0.8020 | 0.2180 | 0.2429 | 0.8326 | 0.9958 | ||
| ZR-75-1 | HR+ | Luminal | GM6001 | MMP | MMP | 7553.096 | uM | inf | inf | 0.8456 | 0.8456 | 0.0000 | 0.1005 | -0.1404 | 1.1407 | |
| ZR-75-1 | HR+ | Luminal | GSK1070916 | AURK | AURK | 9958.001 | uM | 0.60021 | 78.49440 | -0.0998 | -1.0000 | 0.2254 | 0.3728 | 0.7713 | 0.5164 | |
| ZR-75-1 | HR+ | Luminal | GSK1070916 | AURK | AURK | 7931.001 | uM | 13.82030 | 426.03290 | 0.3202 | -1.0000 | 0.3205 | 0.1732 | 0.8820 | 1.2900 | |
| ZR-75-1 | HR+ | Luminal | GSK1070916 | AURK | AURK | 7932.001 | uM | 8.94240 | 7.61130 | 0.2743 | 0.2737 | 4.9198 | 0.1129 | 0.8952 | 1.0256 | |
| ZR-75-1 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 7552.098 | uM | 412.73890 | 81.38380 | 0.5312 | 0.1320 | 0.1887 | 0.2172 | 0.7668 | 1.1882 | |
| ZR-75-1 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 7553.098 | uM | 4.31360 | 5.4880 | 0.1520 | -0.0673 | 0.5247 | 0.2784 | 0.8750 | 1.2325 | |
| ZR-75-1 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 7553.091 | uM | 6.26460 | 8.46190 | -0.9802 | -0.9863 | 3.6237 | 0.4181 | 0.9920 | 0.9738 | |
| ZR-75-1 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 7932.001 | uM | inf | inf | -0.2938 | -0.2938 | 0.0000 | 0.1774 | 0.3309 | 1.0256 | |
| ZR-75-1 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 9958.001 | uM | inf | inf | -0.6349 | -0.6349 | 0.0000 | 0.4214 | 0.4925 | 0.5164 | |
| ZR-75-1 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 7931.001 | uM | inf | 0.06993 | 0.1775 | 0.5164 | 5.0000 | 0.1897 | 0.6174 | 1.2900 | |
| ZR-75-1 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 9958.001 | uM | 0.03119 | 0.03366 | -0.4843 | -0.2129 | 4.6381 | 0.6613 | 0.9667 | 0.5164 | |
| ZR-75-1 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 7932.001 | uM | 0.09236 | 0.06168 | 0.2457 | 0.2730 | 1.9563 | 0.3592 | 0.9698 | 1.0256 | |
| ZR-75-1 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 7931.001 | uM | 0.09071 | 0.07446 | 0.1518 | 0.2690 | 3.9100 | 0.3379 | 0.9744 | 1.2900 | |
| ZR-75-1 | HR+ | Luminal | GW-5074 | CRAF | MAPK | 7553.088 | uM | inf | inf | 0.7728 | 0.7728 | 0.0000 | 0.0453 | 0.5639 | 1.0607 | |
| ZR-75-1 | HR+ | Luminal | Ibandronate | FDPS | 12003.143 | uM | 66.23930 | 80.02160 | -0.1035 | -0.1630 | 1.4928 | 0.3531 | 0.8955 | 1.2499 | ||
| ZR-75-1 | HR+ | Luminal | Ibandronate | FDPS | 11660.143 | uM | 63.75350 | 80.53990 | -0.1812 | -0.2116 | 1.5099 | 0.2999 | 0.9917 | 1.0389 | ||
| ZR-75-1 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 11660.151 | uM | inf | inf | 0.6460 | 0.6460 | 0.0000 | 0.1792 | 0.5635 | 0.9483 |