Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UACC-812 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 10150.001 | uM | 3.88470 | 13.45150 | -0.5015 | -1.0000 | 0.8845 | 0.2772 | 0.8331 | 0.3255 | |
| UACC-812 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 10267.001 | uM | 25.76520 | 31.49210 | -0.0613 | -0.8640 | 5.0000 | 0.0577 | 0.9247 | 0.3957 | |
| UACC-812 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 9913.001 | uM | 25.9350 | 31.80570 | -0.0515 | -0.8870 | 5.0000 | 0.0501 | 0.9461 | 0.3047 | |
| UACC-812 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 7926.001 | uM | 29.80030 | 34.22940 | 0.3012 | -0.4997 | 5.0000 | 0.0234 | 0.9611 | 0.7852 | |
| UACC-812 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 10151.001 | uM | 7.73480 | 8.65470 | -0.3729 | -0.3746 | 4.9753 | 0.1395 | 0.9839 | 0.4212 | |
| UACC-812 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 7547.092 | uM | inf | inf | 0.5248 | 0.5248 | 0.0000 | 0.3088 | 0.1957 | 0.9866 | |
| UACC-812 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 7547.098 | uM | 3.71120 | 11.92710 | -0.8863 | -1.0000 | 0.9410 | 0.4598 | 0.8119 | 1.0399 | |
| UACC-812 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 7926.001 | uM | 28.03790 | 34.93310 | 0.1190 | -1.0000 | 4.9964 | 0.1169 | 0.6478 | 0.7852 | |
| UACC-812 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 10150.001 | uM | 11.48630 | 14.5110 | -0.9569 | -0.9966 | 4.6902 | 0.2332 | 0.7847 | 0.3255 | |
| UACC-812 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 10267.001 | uM | 6.73740 | 8.15430 | -0.7961 | -0.7976 | 4.9966 | 0.2231 | 0.8483 | 0.3957 | |
| UACC-812 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 10151.001 | uM | 7.61480 | 9.49220 | -0.9982 | -1.0000 | 4.9851 | 0.2282 | 0.8669 | 0.4212 | |
| UACC-812 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 9913.001 | uM | 12.93750 | 16.11690 | -0.9831 | -1.0000 | 4.9996 | 0.0837 | 0.9941 | 0.3047 | |
| UACC-812 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 9913.001 | uM | 0.01022 | 0.01151 | -0.3520 | -0.4040 | 4.9494 | 0.9230 | 0.8876 | 0.3047 | |
| UACC-812 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 10151.001 | uM | 0.01620 | 0.01833 | -0.3124 | -0.4280 | 5.0000 | 0.8525 | 0.9598 | 0.4212 | |
| UACC-812 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 7926.001 | uM | 0.02001 | 0.01704 | 0.2456 | 0.2248 | 3.7165 | 0.4375 | 0.9888 | 0.7852 | |
| UACC-812 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 10267.001 | uM | 0.01301 | 0.01496 | -0.4705 | -0.5070 | 4.9999 | 0.8669 | 0.9914 | 0.3957 | |
| UACC-812 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 10150.001 | uM | 0.00995 | 0.01171 | -0.5826 | -0.6272 | 5.0000 | 0.9813 | 0.9937 | 0.3255 | |
| UACC-812 | HER2amp | Luminal | GW843682X | PLK | PLK | 10580.139 | uM | inf | inf | 0.8981 | 0.8981 | 0.0000 | 0.0479 | 0.0681 | 0.9460 | |
| UACC-812 | HER2amp | Luminal | Ibandronate | FDPS | 10580.143 | uM | 114.15680 | 163.93710 | -0.6259 | -0.6377 | 2.2718 | 0.3573 | 0.9687 | 0.8402 | ||
| UACC-812 | HER2amp | Luminal | Ibandronate | FDPS | 10754.143 | uM | 107.10570 | 129.01390 | -0.2993 | -0.3026 | 2.5429 | 0.2974 | 0.9702 | 1.2072 | ||
| UACC-812 | HER2amp | Luminal | Ibandronate | FDPS | 11938.143 | uM | 170.91560 | 198.1490 | -0.5460 | -0.5472 | 5.0000 | 0.2527 | 0.9866 | 0.5258 | ||
| UACC-812 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 10580.139 | uM | inf | inf | 0.7373 | 0.7373 | 0.0000 | 0.1188 | -0.3807 | 0.9460 | |
| UACC-812 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 11938.157 | uM | inf | inf | 0.3417 | 0.3417 | 0.0000 | 0.4595 | -0.0470 | 0.6995 | |
| UACC-812 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 10754.151 | uM | 51.12970 | 2.50620 | 0.5195 | 0.4132 | 0.5807 | 0.1334 | 0.7675 | 0.9579 | |
| UACC-812 | HER2amp | Luminal | IKK16 | IKK | NFKB | 10420.093 | uM | 4.17050 | 5.19540 | -0.9994 | -1.0000 | 5.0000 | 0.4914 | 0.9287 | 0.5629 |