Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| T47D | HR+ | Luminal | Etoposide | TOP2 | TOP | 7543.074 | uM | 1.27360 | 2.0390 | -0.2200 | -0.2408 | 0.8352 | 0.5006 | 0.9947 | 1.2642 | |
| T47D | HR+ | Luminal | Everolimus | MTOR | MTOR | 10939.156 | uM | 2.81250 | 15.69090 | -0.8232 | -1.0000 | 0.6391 | 0.3596 | 0.7936 | 1.6506 | |
| T47D | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 7543.084 | uM | 0.45154 | 0.77159 | -0.9846 | -0.9827 | 2.0288 | 0.5718 | 0.9984 | 1.3431 | |
| T47D | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 10939.149 | uM | inf | inf | 0.9049 | 0.9049 | 0.0000 | 0.0508 | 0.0048 | 1.6748 | |
| T47D | HR+ | Luminal | FTase Inhibitor I | Ftase | MAPK | 10939.154 | uM | inf | inf | 0.9174 | 0.9174 | 0.0000 | 0.0647 | -0.1647 | 1.6876 | |
| T47D | HR+ | Luminal | Gefitinib | EGFR | ErbB | 9033.016 | uM | 14.3940 | 41.37580 | 0.0979 | -1.0000 | 1.0405 | 0.1524 | 0.9168 | 1.3741 | |
| T47D | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 9897.012 | uM | 0.01619 | 0.02075 | -0.8240 | -0.7695 | 3.7518 | 1.1956 | 0.9948 | 0.4748 | |
| T47D | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 9033.075 | uM | 0.82723 | 8.05220 | -0.0808 | -0.3707 | 0.2437 | 0.5524 | 0.950 | 0.9560 | |
| T47D | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 10939.15 | uM | 27.12460 | 228.77690 | 0.4574 | -1.0000 | 0.5152 | 0.1172 | 0.9537 | 1.6881 | ||
| T47D | HR+ | Luminal | GSK1070916 | AURK | AURK | 9897.001 | uM | 3.97790 | 8.83180 | -0.8477 | -1.0000 | 1.3774 | 0.2964 | 0.9251 | 0.5223 | |
| T47D | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 7543.098 | uM | 6.94050 | 3.13250 | 0.2360 | 0.4906 | 4.9999 | 0.1606 | 0.6806 | 1.4503 | |
| T47D | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 7543.091 | uM | 59.20520 | 128.64140 | -0.0338 | -1.0000 | 1.4157 | 0.1462 | 0.9004 | 1.4781 | |
| T47D | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 7542.092 | uM | 13.95950 | 23.03840 | -0.8457 | -1.0000 | 2.1928 | 0.2243 | 0.9768 | 1.5380 | |
| T47D | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 7542.098 | uM | 8.73690 | 16.13020 | -0.9143 | -1.0000 | 1.7918 | 0.2755 | 0.9866 | 1.3028 | |
| T47D | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 7543.071 | uM | 6.37980 | 8.47310 | -0.8878 | -0.8909 | 3.6055 | 0.3792 | 0.9923 | 1.3896 | |
| T47D | HR+ | Luminal | GSK461364 | PLK1 | PLK | 9897.001 | uM | 0.14011 | 1.80350 | -0.9924 | -1.0000 | 0.4300 | 0.5103 | 0.8403 | 0.5223 | |
| T47D | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 9897.001 | uM | 0.04832 | 0.05240 | -0.5184 | -0.2501 | 5.0000 | 0.6230 | 0.9360 | 0.5223 | |
| T47D | HR+ | Luminal | Ibandronate | FDPS | 10939.143 | uM | 34.95340 | 29.34010 | 0.1403 | 0.1394 | 1.8673 | 0.2750 | 0.9904 | 1.7568 | ||
| T47D | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 10939.151 | uM | inf | 0.15627 | 0.7276 | 0.7950 | 0.9765 | 0.0988 | 0.7159 | 1.7384 | |
| T47D | HR+ | Luminal | IKK16 | IKK | NFKB | 7542.1 | uM | 2.96010 | 3.83880 | -0.9445 | -0.9453 | 4.0834 | 0.4290 | 0.9988 | 1.3201 | |
| T47D | HR+ | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 7542.092 | uM | 21.48590 | 33.54160 | -0.9130 | -0.9477 | 2.3870 | 0.4791 | 0.9859 | 1.5380 | |
| T47D | HR+ | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 7543.091 | uM | 17.26270 | 29.18230 | -0.9571 | -0.9844 | 2.0727 | 0.4796 | 0.9970 | 1.4781 | |
| T47D | HR+ | Luminal | Ispinesib | KSP | Kinesin | 7543.067 | uM | 0.08495 | 0.53802 | -0.9958 | -1.0000 | 0.5952 | 0.6303 | 0.9545 | 1.2437 | |
| T47D | HR+ | Luminal | Ixabepilone | TUBB | TUBB | 7543.095 | uM | inf | inf | -0.9968 | -0.9968 | 0.0000 | 0.7292 | 0.5683 | 1.1854 | |
| T47D | HR+ | Luminal | Ixabepilone | TUBB | TUBB | 7542.095 | uM | 0.01353 | 0.02248 | -0.9559 | -0.3943 | 1.1464 | 0.7645 | 0.8742 | 1.2904 |