Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| Torkinib | HCC70 | -4.3010 | 0.9415 | -9.6690 | -9.5655 | -12.1070 | 0.3058 | 0.0350 | 0.0565 | 2.0727 |
| Torkinib | ZR-75-1 | -4.3010 | 0.9479 | -9.8430 | -8.9499 | -10.7280 | 0.5030 | 0.3223 | 0.3234 | 3.6921 |
| Torkinib | MCF7 | -4.3010 | 0.9482 | -10.1570 | -9.6593 | -10.3750 | 0.4305 | 0.1950 | 0.1974 | 2.6031 |
| Torkinib | UACC-812 | -4.3010 | 0.9736 | -8.7280 | -7.8546 | -10.2600 | 0.3573 | 0.2563 | 0.2753 | 4.2197 |
| Torkinib | HCC2185 | -4.3010 | 0.9758 | -8.3570 | -7.4396 | -9.6944 | 0.4359 | 0.3010 | 0.3127 | 4.7229 |
| Torkinib | HCC38 | -4.3010 | 0.9596 | -8.9020 | -8.8385 | -9.6108 | 0.5908 | 0.0409 | 0.0428 | 2.3342 |
| Torkinib | T47DKBLUC | -4.3010 | 0.9063 | -9.3870 | -5.1956 | -9.6065 | 0.4163 | 0.4910 | 0.4949 | 5.3140 |
| Torkinib | MDA-MB-134-VI | -4.3010 | 0.9644 | -8.3700 | -8.1441 | -9.5949 | 0.3310 | 0.0793 | 0.1189 | 3.4999 |
| Torkinib | T47D | -4.3010 | 0.9460 | -9.4110 | -8.5983 | -9.5701 | 0.4377 | 0.2796 | 0.2838 | 3.7359 |
| Torkinib | HCC1428 | -4.3010 | 0.7953 | -7.7250 | -7.4406 | -9.2993 | 0.2643 | 0.0796 | 0.1814 | 4.2525 |
| Torkinib | UACC-893 | -4.3010 | 0.9509 | -7.8850 | -7.5857 | -9.2978 | 0.3751 | 0.1139 | 0.1523 | 4.1641 |
| Ixabepilone | MDA-MB-231 | -4.4045 | 0.9286 | -9.2455 | -9.2112 | -9.2591 | 1.4930 | 0.1324 | 0.1324 | 2.3981 |
| Torkinib | MDA-MB-453 | -4.3010 | 0.9696 | -8.2960 | -7.7064 | -9.1458 | 0.3729 | 0.1987 | 0.2238 | 4.2257 |
| GSK461364 | MDA-MB-157 | -4.4776 | 0.9444 | -9.0436 | -8.9391 | -9.0610 | 2.6360 | 0.2340 | 0.2340 | 3.5893 |
| Torkinib | HCC1569 | -4.3010 | 0.9797 | -7.8180 | -7.8177 | -9.0248 | 0.2628 | 0.0000 | 0.1064 | 3.7403 |
| Torkinib | SK-BR-3 | -4.3010 | 0.9599 | -8.5460 | -7.8042 | -8.9851 | 0.4078 | 0.2510 | 0.2647 | 4.2828 |
| Torkinib | HCC1954 | -4.3010 | 0.9756 | -8.3140 | -8.0526 | -8.9641 | 0.3341 | 0.0911 | 0.1308 | 3.6259 |
| Omipalisib | HCC202 | -4.4776 | 0.9925 | -8.0786 | -8.0068 | -8.9423 | 0.9984 | 0.0758 | 0.0760 | 3.7918 |
| Torkinib | AU565 | -4.3010 | 0.9687 | -8.5760 | -8.0828 | -8.9348 | 0.5460 | 0.2310 | 0.2346 | 4.0207 |
| Ixabepilone | HCC70 | -4.4045 | 0.9226 | -8.2105 | -7.9797 | -8.9212 | 0.4724 | 0.1109 | 0.1248 | 3.8014 |
| Omipalisib | BT-483 | -4.4776 | 0.9810 | -7.7216 | -7.1924 | -8.8962 | 0.5153 | 0.2330 | 0.2490 | 5.0745 |
| Ixabepilone | SUM52PE | -4.4045 | 0.8127 | -8.4715 | -8.2024 | -8.8825 | 0.8237 | 0.1911 | 0.2049 | 4.0147 |
| Torkinib | MCF 10F | -4.3010 | 0.9683 | -8.7050 | -8.2104 | -8.8465 | 0.5975 | 0.2470 | 0.2488 | 3.9764 |
| Docetaxel | Hs 578T | -5.0000 | 0.9693 | -8.6405 | -8.5044 | -8.8125 | 1.4793 | 0.1759 | 0.1761 | 4.2545 |
| Docetaxel | SUM159PT | -5.0000 | 0.9753 | -8.7915 | -8.7477 | -8.8094 | 2.1380 | 0.0956 | 0.0956 | 3.6627 |