Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
Download: Excel (XLSX), Comma-separated (CSV)
| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| Temsirolimus | HCC38 | -3.8761 | 0.8186 | -5.6571 | -5.6573 | NaN | 0.2527 | 0.0000 | 0.2618 | 5.3829 |
| Temsirolimus | HCC1954 | -3.8761 | 0.7828 | -5.6971 | -5.6974 | NaN | 0.2574 | 0.0000 | 0.2536 | 5.4665 |
| Torkinib | MDA-MB-436 | -4.3010 | 0.8884 | -7.4470 | -6.9431 | -8.1443 | 0.2586 | 0.1296 | 0.2455 | 4.7721 |
| Everolimus | HCC1569 | -4.1759 | 0.7149 | -5.1081 | -5.1083 | NaN | 0.2613 | 0.0000 | 0.3629 | 6.2645 |
| Torkinib | SUM149PT | -4.3010 | 0.9695 | -7.3790 | -7.3786 | NaN | 0.2616 | 0.0000 | 0.1354 | 4.1620 |
| Torkinib | HCC1569 | -4.3010 | 0.9797 | -7.8180 | -7.8177 | -9.0248 | 0.2628 | 0.0000 | 0.1064 | 3.7403 |
| Torkinib | HCC1428 | -4.3010 | 0.7953 | -7.7250 | -7.4406 | -9.2993 | 0.2643 | 0.0796 | 0.1814 | 4.2525 |
| 5-DFUR | SK-BR-3 | -2.3010 | 0.8096 | -2.5574 | -2.5574 | NaN | 0.2672 | 0.0000 | 0.4606 | 6.9216 |
| 5-FU | ZR75B | -1.7167 | 0.8295 | -3.7187 | -3.7191 | NaN | 0.2688 | 0.0000 | 0.2246 | 5.2233 |
| Everolimus | SUM225CWN | -4.1759 | 0.7658 | -6.2099 | -6.2102 | NaN | 0.2714 | 0.0000 | 0.2190 | 5.2607 |
| (Z)-4-Hydroxytamoxifen | MDA-MB-134-VI | -3.7773 | 0.7481 | -3.0115 | -3.7773 | NaN | 0.2750 | 0.0000 | 0.6189 | 7.7008 |
| Temsirolimus | HCC70 | -3.8761 | 0.7768 | -5.2526 | -5.2526 | NaN | 0.2788 | 0.0000 | 0.2942 | 5.9779 |
| Temsirolimus | AU565 | -3.8761 | 0.8897 | -6.2321 | -6.2320 | NaN | 0.2802 | 0.0000 | 0.1795 | 4.9226 |
| Temsirolimus | MB 157 | -3.8761 | 0.8548 | -6.0781 | -6.0777 | NaN | 0.2809 | 0.0000 | 0.1940 | 5.1396 |
| Temsirolimus | MCF 10F | -3.8761 | 0.7792 | -5.3001 | -5.3001 | NaN | 0.2879 | 0.0000 | 0.2801 | 5.9814 |
| Everolimus | HCC1419 | -4.1759 | 0.7527 | -6.7369 | -4.1759 | -8.4570 | 0.2890 | 0.4251 | 0.5136 | 6.5850 |
| Temsirolimus | HCC2185 | -3.8761 | 0.7759 | -5.3431 | -5.3430 | NaN | 0.2905 | 0.0000 | 0.2727 | 5.8405 |
| Everolimus | 184B5 | -4.1759 | 0.7009 | -5.0564 | -5.0563 | NaN | 0.2937 | 0.0000 | 0.3554 | 6.4059 |
| Temsirolimus | ZR-75-1 | -3.8761 | 0.8384 | -5.7221 | -5.7220 | NaN | 0.2954 | 0.0000 | 0.2217 | 5.2885 |
| Everolimus | MDA-MB-468 | -4.1759 | 0.7951 | -5.6979 | -5.6978 | NaN | 0.2955 | 0.0000 | 0.2620 | 5.8209 |
| Triciribine | HCC1395 | -4.4776 | 0.8151 | -4.3237 | -4.4776 | -5.8158 | 0.2974 | 0.1533 | 0.5989 | 7.6593 |
| Temsirolimus | ZR75B | -3.8761 | 0.8815 | -6.1101 | -6.0135 | -7.0029 | 0.2982 | 0.0321 | 0.2038 | 5.2739 |
| Temsirolimus | BT-549 | -3.8761 | 0.8458 | -6.1601 | -6.1599 | NaN | 0.2987 | 0.0000 | 0.1721 | 5.0558 |
| Pevonedistat | HCC1395 | -4.1759 | 0.8743 | -4.1666 | -4.5519 | -6.0401 | 0.3010 | 0.0000 | 0.5016 | 7.2534 |
| Everolimus | HCC70 | -4.1759 | 0.8194 | -5.7659 | -5.7658 | NaN | 0.3055 | 0.0000 | 0.2464 | 5.7929 |