Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| Torkinib | HCC70 | -4.3010 | 0.9415 | -9.6690 | -9.5655 | -12.1070 | 0.3058 | 0.0350 | 0.0565 | 2.0727 |
| Torkinib | HCC38 | -4.3010 | 0.9596 | -8.9020 | -8.8385 | -9.6108 | 0.5908 | 0.0409 | 0.0428 | 2.3342 |
| Ixabepilone | MDA-MB-231 | -4.4045 | 0.9286 | -9.2455 | -9.2112 | -9.2591 | 1.4930 | 0.1324 | 0.1324 | 2.3981 |
| Gemcitabine | HCC1806 | -3.8416 | 0.9790 | -8.6516 | -8.5897 | -8.7366 | 2.1030 | 0.1252 | 0.1252 | 2.5814 |
| Torkinib | MCF7 | -4.3010 | 0.9482 | -10.1570 | -9.6593 | -10.3750 | 0.4305 | 0.1950 | 0.1974 | 2.6031 |
| Topotecan | HCC38 | -3.9626 | 0.9866 | -8.3826 | -8.3335 | -8.6100 | 1.5540 | 0.0790 | 0.0790 | 2.7260 |
| Gemcitabine | HCC38 | -3.8416 | 0.9855 | -8.2706 | -8.2417 | -8.3689 | 3.4500 | 0.1041 | 0.1041 | 2.7812 |
| Ixabepilone | HCC1187 | -4.4045 | 0.9872 | -8.6105 | -8.6026 | -8.7327 | 3.2200 | 0.0327 | 0.0327 | 2.8018 |
| Ixabepilone | HCC1954 | -4.4045 | 0.9770 | -8.5815 | -8.5657 | -8.6882 | 1.6170 | 0.0543 | 0.0543 | 2.8292 |
| Geldanamycin | SUM159PT | -4.0000 | 0.9944 | -8.1560 | -8.1410 | -8.1970 | 2.6035 | 0.0400 | 0.0400 | 2.8392 |
| Geldanamycin | SUM149PT | -4.0000 | 0.9686 | -8.1950 | -8.1819 | -8.2478 | 3.9830 | 0.0572 | 0.0572 | 2.9240 |
| Geldanamycin | MCF 10A | -4.0000 | 0.9888 | -8.1900 | -8.1632 | -8.2354 | 2.8000 | 0.0602 | 0.0602 | 2.9586 |
| Ixabepilone | AU565 | -4.4045 | 0.9793 | -8.3790 | -8.3705 | -8.4523 | 3.0590 | 0.0256 | 0.0256 | 2.9694 |
| Bortezomib | AU565 | -3.7773 | 0.9948 | -7.6683 | -7.6678 | -7.7217 | 3.7605 | 0.0035 | 0.0035 | 2.9784 |
| Vinorelbine | Hs 578T | -4.3335 | 0.9828 | -8.4295 | -8.3827 | -8.6943 | 2.6070 | 0.0730 | 0.0730 | 3.0790 |
| Bortezomib | HCC1187 | -3.7773 | 0.9896 | -7.6223 | -7.6220 | -7.8008 | 3.0070 | 0.0000 | 0.0000 | 3.0973 |
| Bortezomib | BT-549 | -3.7773 | 0.9877 | -7.5953 | -7.5955 | -7.6152 | 3.9975 | 0.0000 | 0.0000 | 3.0996 |
| Ixabepilone | MDA-MB-468 | -4.4045 | 0.9778 | -8.3945 | -8.3616 | -8.4847 | 1.5860 | 0.0568 | 0.0568 | 3.1497 |
| Taxol | SUM159PT | -4.4776 | 0.9820 | -8.4646 | -8.4355 | -8.4836 | 2.2040 | 0.0682 | 0.0682 | 3.1856 |
| Gemcitabine | BT-549 | -3.8416 | 0.9956 | -8.0476 | -7.9848 | -8.0901 | 1.7390 | 0.1050 | 0.1050 | 3.1948 |
| Geldanamycin | BT-549 | -4.0000 | 0.9884 | -8.2410 | -8.2061 | -8.2620 | 3.9980 | 0.1095 | 0.1095 | 3.2904 |
| Ixabepilone | HCC1806 | -4.4045 | 0.9689 | -8.5525 | -8.4669 | -8.6382 | 1.2420 | 0.1087 | 0.1087 | 3.3033 |
| Torkinib | SUM159PT | -4.3010 | 0.9779 | -8.4820 | -8.2954 | -8.5069 | 0.5401 | 0.1033 | 0.1082 | 3.3095 |
| CGC-11144 | MDA-MB-157 | -3.1500 | 0.9911 | -6.7985 | -6.7957 | -7.0163 | 1.9580 | 0.0057 | 0.0057 | 3.3156 |
| CGC-11144 | T47D | -3.1500 | 0.9900 | -6.8050 | -6.8048 | -6.9870 | 2.1540 | 0.0000 | 0.0000 | 3.3268 |