Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1806 | AZD-6482 | 1 | 72 | 1.0 | 11781.3 | 11709.8 | 1742.8 | 0.0 | 1.000 | 1.010 | 2.748 | HCC1806 AZD6482 0 1 72 |
| HCC1806 | AZD8055 | 1 | 72 | 1.0 | 5727.5 | 11579.3 | 1742.8 | 0.0 | 0.546 | 0.495 | 2.732 | HCC1806 AZD8055 0 1 72 |
| HCC1806 | AS605240 | 1 | 72 | 1.0 | 10421.8 | 11546.3 | 1742.8 | 0.0 | 0.926 | 0.903 | 2.728 | HCC1806 AS605240 0 1 72 |
| HCC1806 | AZD-6482 | 1 | 72 | 0.32 | 11558.3 | 11709.8 | 1742.8 | -0.495 | 0.991 | 0.987 | 2.748 | HCC1806 AZD6482 0 1 72 |
| HCC1806 | AZD8055 | 1 | 72 | 0.01 | 10460.5 | 11579.3 | 1742.8 | -2.0 | 0.927 | 0.903 | 2.732 | HCC1806 AZD8055 0 1 72 |
| HCC1806 | AZD8055 | 1 | 72 | 0.32 | 5696.0 | 11579.3 | 1742.8 | -0.495 | 0.543 | 0.492 | 2.732 | HCC1806 AZD8055 0 1 72 |
| HCC1806 | AS605240 | 1 | 72 | 0.01 | 11617.5 | 11546.3 | 1742.8 | -2.0 | 1.000 | 1.010 | 2.728 | HCC1806 AS605240 0 1 72 |
| HCC1806 | AS605240 | 1 | 72 | 0.32 | 11293.3 | 11546.3 | 1742.8 | -0.495 | 0.984 | 0.978 | 2.728 | HCC1806 AS605240 0 1 72 |
| HCC1806 | AZD-6482 | 1 | 72 | 0.0032 | 11393.8 | 11709.8 | 1742.8 | -2.49 | 0.980 | 0.973 | 2.748 | HCC1806 AZD6482 0 1 72 |
| HCC1806 | AZD-6482 | 1 | 72 | 0.1 | 12053.8 | 11709.8 | 1742.8 | -1.0 | 1.020 | 1.030 | 2.748 | HCC1806 AZD6482 0 1 72 |
| HCC1806 | AZD8055 | 1 | 72 | 0.001 | 11605.5 | 11579.3 | 1742.8 | -3.0 | 1.000 | 1.000 | 2.732 | HCC1806 AZD8055 0 1 72 |
| HCC1806 | AZD8055 | 1 | 72 | 0.0032 | 11161.5 | 11579.3 | 1742.8 | -2.49 | 0.973 | 0.964 | 2.732 | HCC1806 AZD8055 0 1 72 |
| HCC1806 | AZD8055 | 1 | 72 | 0.032 | 9150.5 | 11579.3 | 1742.8 | -1.49 | 0.835 | 0.790 | 2.732 | HCC1806 AZD8055 0 1 72 |
| HCC1806 | AZD8055 | 1 | 72 | 0.1 | 7212.5 | 11579.3 | 1742.8 | -1.0 | 0.682 | 0.623 | 2.732 | HCC1806 AZD8055 0 1 72 |
| HCC1806 | AS605240 | 1 | 72 | 0.001 | 11618.8 | 11546.3 | 1742.8 | -3.0 | 1.000 | 1.010 | 2.728 | HCC1806 AS605240 0 1 72 |
| HCC1806 | AS605240 | 1 | 72 | 0.0032 | 11624.3 | 11546.3 | 1742.8 | -2.49 | 1.000 | 1.010 | 2.728 | HCC1806 AS605240 0 1 72 |
| HCC1806 | AS605240 | 1 | 72 | 0.032 | 11947.8 | 11546.3 | 1742.8 | -1.49 | 1.030 | 1.030 | 2.728 | HCC1806 AS605240 0 1 72 |
| HCC1806 | AS605240 | 1 | 72 | 0.1 | 11678.3 | 11546.3 | 1742.8 | -1.0 | 1.010 | 1.010 | 2.728 | HCC1806 AS605240 0 1 72 |
| HCC1806 | AS605240 | 1 | 72 | 3.2 | 10191.5 | 11546.3 | 1742.8 | 0.505 | 0.911 | 0.883 | 2.728 | HCC1806 AS605240 0 1 72 |
| HCC1806 | AZD-6482 | 1 | 72 | 0.001 | 11446.8 | 11709.8 | 1742.8 | -3.0 | 0.984 | 0.978 | 2.748 | HCC1806 AZD6482 0 1 72 |
| HCC1806 | AZD-6482 | 1 | 72 | 0.01 | 11388.3 | 11709.8 | 1742.8 | -2.0 | 0.980 | 0.973 | 2.748 | HCC1806 AZD6482 0 1 72 |
| HCC1806 | AZD-6482 | 1 | 72 | 0.032 | 11940.3 | 11709.8 | 1742.8 | -1.49 | 1.010 | 1.020 | 2.748 | HCC1806 AZD6482 0 1 72 |
| HCC1806 | AZD-6482 | 1 | 72 | 3.2 | 11967.3 | 11709.8 | 1742.8 | 0.505 | 1.020 | 1.020 | 2.748 | HCC1806 AZD6482 0 1 72 |
| HCC1806 | Dactolisib | 1 | 72 | 0.001 | 11630.8 | 11670.0 | 1742.8 | -3.0 | 0.998 | 0.997 | 2.743 | HCC1806 BEZ235 0 1 72 |
| HCC1806 | AZD8055 | 1 | 72 | 3.2 | 5607.0 | 11579.3 | 1742.8 | 0.505 | 0.534 | 0.484 | 2.732 | HCC1806 AZD8055 0 1 72 |