Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)

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Cell line Drug name Experimental replicate Timepoint Drug concentration Live cell count Average live cell count, DMSO control Average live cell count (time = 0) Log10(drug concentration) GR value Relative cell count (treatment versus DMSO) Cell doublings (DMSO control) Experiment name
BT-20 Torin2 3 72
3.2
 47.8 3225.3 586.9
0.505
 -0.640 0.015 2.458
BT20 Torin2 0 3
BT-20 Omipalisib 3 72
3.2
 59.8 3523.0 586.9
0.505
 -0.587 0.017 2.586
BT20 GSK458 0 3
BT-20 Omipalisib 2 72
3.2
 65.0 3349.0 1018.6
0.505
 -0.799 0.019 1.717
BT20 GSK458 0 2
BT-20 Torin2 2 72
3.2
 85.5 3386.5 1018.6
0.505
 -0.761 0.025 1.733
BT20 Torin2 0 2
HCC70 Omipalisib 2 72
3.2
 92.5 2319.3 722.8
0.505
 -0.705 0.040 1.682
HCC70 GSK458 0 2 72
BT-20 Omipalisib 1 72
3.2
 95.5 6095.3 1443.3
0.505
 -0.729 0.016 2.078
BT20 GSK458 0 1
BT-20 Torin2 1 72
3.2
 96.0 5846.0 1443.3
0.505
 -0.739 0.016 2.018
BT20 Torin2 0 1
Hs 578T Omipalisib 2 72
3.2
 99.3 3550.3 624.7
0.505
 -0.520 0.028 2.507
Hs578T GSK458 2
Hs 578T Buparlisib 3 72
3.2
 115.3 4235.0 571.3
0.505
 -0.425 0.027 2.890
Hs578T BKM120 3
Hs 578T Torin2 2 72
3.2
 127.3 3604.3 624.7
0.505
 -0.467 0.035 2.528
Hs578T Torin2 2
HCC70 Omipalisib 3 72
3.2
 145.0 2841.5 517.3
0.505
 -0.404 0.051 2.458
HCC70 GSK458 0 3 72
Hs 578T Buparlisib 1 72
3.2
 146.5 3651.8 873.1
0.505
 -0.579 0.040 2.064
Hs578T BKM120 1
BT-20 Omipalisib 3 72
1.0
 151.5 3523.0 586.9
0.0
 -0.408 0.043 2.586
BT20 GSK458 0 3
HCC70 Omipalisib 2 72
1.0
 158.0 2319.3 722.8
0.0
 -0.595 0.068 1.682
HCC70 GSK458 0 2 72
Hs 578T Buparlisib 2 72
3.2
 158.8 3566.8 624.7
0.505
 -0.420 0.045 2.513
Hs578T BKM120 2
HCC70 Omipalisib 1 72
3.2
 159.3 3280.0 1279.8
0.505
 -0.785 0.049 1.358
HCC70 GSK458 0 1 72
HCC70 Torin2 3 72
3.2
 160.0 2778.8 517.3
0.505
 -0.384 0.058 2.425
HCC70 Torin2 0 3 72
Hs 578T Omipalisib 1 72
3.2
 169.3 3689.5 873.1
0.505
 -0.546 0.046 2.079
Hs578T GSK458 1
HCC38 Torin2 2 72
3.2
 170.5 3044.5 690.5
0.505
 -0.480 0.056 2.140
HCC38 Torin2 0 2 72
HCC38 Omipalisib 2 72
3.2
 179.0 3009.3 690.5
0.505
 -0.470 0.060 2.124
HCC38 GSK458 0 2 72
Hs 578T Torin2 3 72
3.2
 185.0 4103.3 571.3
0.505
 -0.327 0.045 2.844
Hs578T Torin2 3
HCC70 Torin2 2 72
3.2
 187.8 2562.3 722.8
0.505
 -0.522 0.073 1.826
HCC70 Torin2 0 2 72
HCC70 Torin2 1 72
3.2
 212.0 3294.3 1279.8
0.505
 -0.732 0.064 1.364
HCC70 Torin2 0 1 72
Hs 578T Torin2 2 72
1.0
 212.3 3604.3 624.7
0.0
 -0.347 0.059 2.528
Hs578T Torin2 2
HCC70 Omipalisib 3 72
1.0
 228.8 2841.5 517.3
0.0
 -0.283 0.081 2.458
HCC70 GSK458 0 3 72
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