Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | Omipalisib | 2 | 72 | 3.2 | 65.0 | 3349.0 | 1018.6 | 0.505 | -0.799 | 0.019 | 1.717 | BT20 GSK458 0 2 |
| HCC70 | Omipalisib | 1 | 72 | 3.2 | 159.3 | 3280.0 | 1279.8 | 0.505 | -0.785 | 0.049 | 1.358 | HCC70 GSK458 0 1 72 |
| BT-20 | Torin2 | 2 | 72 | 3.2 | 85.5 | 3386.5 | 1018.6 | 0.505 | -0.761 | 0.025 | 1.733 | BT20 Torin2 0 2 |
| BT-20 | Torin2 | 1 | 72 | 3.2 | 96.0 | 5846.0 | 1443.3 | 0.505 | -0.739 | 0.016 | 2.018 | BT20 Torin2 0 1 |
| HCC70 | Torin2 | 1 | 72 | 3.2 | 212.0 | 3294.3 | 1279.8 | 0.505 | -0.732 | 0.064 | 1.364 | HCC70 Torin2 0 1 72 |
| BT-20 | Omipalisib | 1 | 72 | 3.2 | 95.5 | 6095.3 | 1443.3 | 0.505 | -0.729 | 0.016 | 2.078 | BT20 GSK458 0 1 |
| HCC70 | Omipalisib | 2 | 72 | 3.2 | 92.5 | 2319.3 | 722.8 | 0.505 | -0.705 | 0.040 | 1.682 | HCC70 GSK458 0 2 72 |
| HCC70 | Omipalisib | 1 | 72 | 1.0 | 253.0 | 3280.0 | 1279.8 | 0.0 | -0.697 | 0.077 | 1.358 | HCC70 GSK458 0 1 72 |
| BT-20 | Torin2 | 3 | 72 | 3.2 | 47.8 | 3225.3 | 586.9 | 0.505 | -0.640 | 0.015 | 2.458 | BT20 Torin2 0 3 |
| HCC38 | Torin2 | 3 | 72 | 3.2 | 304.0 | 3083.5 | 1180.5 | 0.505 | -0.624 | 0.099 | 1.385 | HCC38 Torin2 0 3 72 |
| HCC70 | Omipalisib | 2 | 72 | 1.0 | 158.0 | 2319.3 | 722.8 | 0.0 | -0.595 | 0.068 | 1.682 | HCC70 GSK458 0 2 72 |
| HCC70 | Omipalisib | 1 | 72 | 0.32 | 383.8 | 3280.0 | 1279.8 | -0.495 | -0.588 | 0.117 | 1.358 | HCC70 GSK458 0 1 72 |
| BT-20 | Omipalisib | 3 | 72 | 3.2 | 59.8 | 3523.0 | 586.9 | 0.505 | -0.587 | 0.017 | 2.586 | BT20 GSK458 0 3 |
| Hs 578T | Buparlisib | 1 | 72 | 3.2 | 146.5 | 3651.8 | 873.1 | 0.505 | -0.579 | 0.040 | 2.064 | Hs578T BKM120 1 |
| BT-20 | Omipalisib | 2 | 72 | 1.0 | 235.0 | 3349.0 | 1018.6 | 0.0 | -0.574 | 0.070 | 1.717 | BT20 GSK458 0 2 |
| BT-20 | Omipalisib | 1 | 72 | 1.0 | 262.3 | 6095.3 | 1443.3 | 0.0 | -0.560 | 0.043 | 2.078 | BT20 GSK458 0 1 |
| Hs 578T | Omipalisib | 1 | 72 | 3.2 | 169.3 | 3689.5 | 873.1 | 0.505 | -0.546 | 0.046 | 2.079 | Hs578T GSK458 1 |
| HCC70 | Torin2 | 2 | 72 | 3.2 | 187.8 | 2562.3 | 722.8 | 0.505 | -0.522 | 0.073 | 1.826 | HCC70 Torin2 0 2 72 |
| Hs 578T | Omipalisib | 2 | 72 | 3.2 | 99.3 | 3550.3 | 624.7 | 0.505 | -0.520 | 0.028 | 2.507 | Hs578T GSK458 2 |
| HCC38 | Omipalisib | 3 | 72 | 3.2 | 429.5 | 3215.3 | 1180.5 | 0.505 | -0.503 | 0.134 | 1.446 | HCC38 GSK458 0 3 72 |
| HCC70 | Buparlisib | 1 | 72 | 3.2 | 501.8 | 3318.0 | 1279.8 | 0.505 | -0.494 | 0.151 | 1.374 | HCC70 BKM120 0 1 72 |
| HCC38 | Torin2 | 2 | 72 | 3.2 | 170.5 | 3044.5 | 690.5 | 0.505 | -0.480 | 0.056 | 2.140 | HCC38 Torin2 0 2 72 |
| HCC70 | Torin2 | 1 | 72 | 1.0 | 526.5 | 3294.3 | 1279.8 | 0.0 | -0.479 | 0.160 | 1.364 | HCC70 Torin2 0 1 72 |
| HCC70 | Omipalisib | 1 | 72 | 0.1 | 538.5 | 3280.0 | 1279.8 | -1.0 | -0.471 | 0.164 | 1.358 | HCC70 GSK458 0 1 72 |
| HCC38 | Omipalisib | 2 | 72 | 3.2 | 179.0 | 3009.3 | 690.5 | 0.505 | -0.470 | 0.060 | 2.124 | HCC38 GSK458 0 2 72 |