Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)

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Cell line Drug name Experimental replicate Timepoint Drug concentration Live cell count Average live cell count, DMSO control Average live cell count (time = 0) Log10(drug concentration) GR value Relative cell count (treatment versus DMSO) Cell doublings (DMSO control) Experiment name
HCC70 WYE-125132 2 72
1.0
 1402.5 2308.5 722.8
0.0
 0.485 0.608 1.675
HCC70 WYE125132 0 2 72
HCC70 WYE-125132 2 72
0.001
 2297.5 2308.5 722.8
-3.0
 0.994 0.995 1.675
HCC70 WYE125132 0 2 72
HCC70 WYE-125132 2 72
0.32
 1397.0 2308.5 722.8
-0.495
 0.482 0.605 1.675
HCC70 WYE125132 0 2 72
HCC70 WYE-125132 2 72
0.1
 1462.3 2308.5 722.8
-1.0
 0.523 0.633 1.675
HCC70 WYE125132 0 2 72
HCC70 WYE-125132 2 72
3.2
 1379.5 2308.5 722.8
0.505
 0.471 0.598 1.675
HCC70 WYE125132 0 2 72
HCC70 WYE-125132 2 72
0.0032
 2162.8 2308.5 722.8
-2.49
 0.924 0.937 1.675
HCC70 WYE125132 0 2 72
HCC70 WYE-125132 2 72
0.032
 1724.8 2308.5 722.8
-1.49
 0.681 0.747 1.675
HCC70 WYE125132 0 2 72
HCC70 WYE-125132 2 72
0.01
 2029.3 2308.5 722.8
-2.0
 0.852 0.879 1.675
HCC70 WYE125132 0 2 72
HCC70 GDC-0980 2 72
0.32
 1350.5 2310.0 722.8
-0.495
 0.452 0.585 1.676
HCC70 GDC0980 0 2 72
HCC70 GDC-0980 2 72
0.032
 2236.5 2310.0 722.8
-1.49
 0.962 0.968 1.676
HCC70 GDC0980 0 2 72
HCC70 GDC-0980 2 72
0.0032
 2472.8 2310.0 722.8
-2.49
 1.080 1.070 1.676
HCC70 GDC0980 0 2 72
HCC70 GDC-0980 2 72
3.2
 623.0 2310.0 722.8
0.505
 -0.085 0.270 1.676
HCC70 GDC0980 0 2 72
HCC70 GDC-0980 2 72
1.0
 1043.3 2310.0 722.8
0.0
 0.245 0.452 1.676
HCC70 GDC0980 0 2 72
HCC70 GDC-0980 2 72
0.1
 1822.5 2310.0 722.8
-1.0
 0.736 0.789 1.676
HCC70 GDC0980 0 2 72
HCC70 GDC-0980 2 72
0.001
 2471.0 2310.0 722.8
-3.0
 1.080 1.070 1.676
HCC70 GDC0980 0 2 72
HCC70 GDC-0980 2 72
0.01
 2388.0 2310.0 722.8
-2.0
 1.040 1.030 1.676
HCC70 GDC0980 0 2 72
HCC70 Dactolisib 2 72
1.0
 1321.3 2310.8 722.8
0.0
 0.433 0.572 1.677
HCC70 BEZ235 0 2 72
HCC70 Dactolisib 2 72
0.032
 1708.0 2310.8 722.8
-1.49
 0.670 0.739 1.677
HCC70 BEZ235 0 2 72
HCC70 Dactolisib 2 72
0.0032
 2137.3 2310.8 722.8
-2.49
 0.909 0.925 1.677
HCC70 BEZ235 0 2 72
HCC70 Dactolisib 2 72
0.1
 1557.0 2310.8 722.8
-1.0
 0.580 0.674 1.677
HCC70 BEZ235 0 2 72
HCC70 Dactolisib 2 72
3.2
 1033.3 2310.8 722.8
0.505
 0.238 0.447 1.677
HCC70 BEZ235 0 2 72
HCC70 Dactolisib 2 72
0.01
 2010.0 2310.8 722.8
-2.0
 0.840 0.870 1.677
HCC70 BEZ235 0 2 72
HCC70 Dactolisib 2 72
0.001
 2350.5 2310.8 722.8
-3.0
 1.020 1.020 1.677
HCC70 BEZ235 0 2 72
HCC70 Dactolisib 2 72
0.32
 1509.8 2310.8 722.8
-0.495
 0.552 0.653 1.677
HCC70 BEZ235 0 2 72
HCC70 Omipalisib 2 72
0.32
 281.3 2319.3 722.8
-0.495
 -0.429 0.121 1.682
HCC70 GSK458 0 2 72
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