Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC70 | Trametinib | 3 | 72 | 0.032 | 1711.8 | 2852.5 | 517.3 | -1.49 | 0.626 | 0.600 | 2.463 | HCC70 Trametinib 0 3 72 |
| HCC70 | Trametinib | 3 | 72 | 0.1 | 1461.5 | 2852.5 | 517.3 | -1.0 | 0.524 | 0.512 | 2.463 | HCC70 Trametinib 0 3 72 |
| HCC70 | Trametinib | 3 | 72 | 0.32 | 1458.5 | 2852.5 | 517.3 | -0.495 | 0.523 | 0.511 | 2.463 | HCC70 Trametinib 0 3 72 |
| HCC70 | Trametinib | 3 | 72 | 1.0 | 1546.5 | 2852.5 | 517.3 | 0.0 | 0.560 | 0.542 | 2.463 | HCC70 Trametinib 0 3 72 |
| HCC70 | Trametinib | 3 | 72 | 3.2 | 1619.0 | 2852.5 | 517.3 | 0.505 | 0.589 | 0.568 | 2.463 | HCC70 Trametinib 0 3 72 |
| HCC70 | WYE-125132 | 3 | 72 | 0.001 | 2740.8 | 2762.5 | 517.3 | -3.0 | 0.993 | 0.992 | 2.417 | HCC70 WYE125132 0 3 72 |
| HCC70 | WYE-125132 | 3 | 72 | 0.0032 | 2679.5 | 2762.5 | 517.3 | -2.49 | 0.975 | 0.970 | 2.417 | HCC70 WYE125132 0 3 72 |
| HCC70 | WYE-125132 | 3 | 72 | 0.01 | 2487.0 | 2762.5 | 517.3 | -2.0 | 0.915 | 0.900 | 2.417 | HCC70 WYE125132 0 3 72 |
| HCC70 | WYE-125132 | 3 | 72 | 0.032 | 1949.0 | 2762.5 | 517.3 | -1.49 | 0.731 | 0.706 | 2.417 | HCC70 WYE125132 0 3 72 |
| HCC70 | WYE-125132 | 3 | 72 | 0.1 | 1716.5 | 2762.5 | 517.3 | -1.0 | 0.643 | 0.621 | 2.417 | HCC70 WYE125132 0 3 72 |
| HCC70 | WYE-125132 | 3 | 72 | 0.32 | 1600.5 | 2762.5 | 517.3 | -0.495 | 0.596 | 0.579 | 2.417 | HCC70 WYE125132 0 3 72 |
| HCC70 | WYE-125132 | 3 | 72 | 1.0 | 1682.0 | 2762.5 | 517.3 | 0.0 | 0.629 | 0.609 | 2.417 | HCC70 WYE125132 0 3 72 |
| HCC70 | WYE-125132 | 3 | 72 | 3.2 | 1591.0 | 2762.5 | 517.3 | 0.505 | 0.592 | 0.576 | 2.417 | HCC70 WYE125132 0 3 72 |
| HCC70 | XL147 | 3 | 72 | 0.001 | 2845.3 | 2882.5 | 517.3 | -3.0 | 0.990 | 0.987 | 2.478 | HCC70 XL147 0 3 72 |
| HCC70 | XL147 | 3 | 72 | 0.0032 | 2735.5 | 2882.5 | 517.3 | -2.49 | 0.958 | 0.949 | 2.478 | HCC70 XL147 0 3 72 |
| HCC70 | XL147 | 3 | 72 | 0.01 | 3058.8 | 2882.5 | 517.3 | -2.0 | 1.050 | 1.060 | 2.478 | HCC70 XL147 0 3 72 |
| HCC70 | XL147 | 3 | 72 | 0.032 | 2863.5 | 2882.5 | 517.3 | -1.49 | 0.995 | 0.993 | 2.478 | HCC70 XL147 0 3 72 |
| HCC70 | XL147 | 3 | 72 | 0.1 | 3026.5 | 2882.5 | 517.3 | -1.0 | 1.040 | 1.050 | 2.478 | HCC70 XL147 0 3 72 |
| HCC70 | XL147 | 3 | 72 | 0.32 | 2978.5 | 2882.5 | 517.3 | -0.495 | 1.030 | 1.030 | 2.478 | HCC70 XL147 0 3 72 |
| HCC70 | XL147 | 3 | 72 | 1.0 | 3115.8 | 2882.5 | 517.3 | 0.0 | 1.060 | 1.080 | 2.478 | HCC70 XL147 0 3 72 |
| HCC70 | XL147 | 3 | 72 | 3.2 | 2979.3 | 2882.5 | 517.3 | 0.505 | 1.030 | 1.030 | 2.478 | HCC70 XL147 0 3 72 |
| HCC70 | ZSTK474 | 3 | 72 | 0.001 | 2995.3 | 2931.3 | 517.3 | -3.0 | 1.020 | 1.020 | 2.502 | HCC70 ZSTK474 0 3 72 |
| HCC70 | ZSTK474 | 3 | 72 | 0.0032 | 2921.0 | 2931.3 | 517.3 | -2.49 | 0.997 | 0.997 | 2.502 | HCC70 ZSTK474 0 3 72 |
| HCC70 | ZSTK474 | 3 | 72 | 0.01 | 3124.3 | 2931.3 | 517.3 | -2.0 | 1.050 | 1.070 | 2.502 | HCC70 ZSTK474 0 3 72 |
| HCC70 | ZSTK474 | 3 | 72 | 0.032 | 2965.0 | 2931.3 | 517.3 | -1.49 | 1.010 | 1.010 | 2.502 | HCC70 ZSTK474 0 3 72 |