Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)

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Cell line Drug name Experimental replicate Timepoint Drug concentration Live cell count Average live cell count, DMSO control Average live cell count (time = 0) Log10(drug concentration) GR value Relative cell count (treatment versus DMSO) Cell doublings (DMSO control) Experiment name
HCC1806 Dactolisib 2 72
0.32
 4335.3 11670.0 1643.3
-0.495
 0.409 0.371 2.828
HCC1806 BEZ235 0 2 72
HCC1806 Dactolisib 2 72
1.0
 1879.0 11670.0 1643.3
0.0
 0.049 0.161 2.828
HCC1806 BEZ235 0 2 72
HCC1806 Dactolisib 2 72
3.2
 1409.8 11670.0 1643.3
0.505
 -0.053 0.121 2.828
HCC1806 BEZ235 0 2 72
HCC1806 Buparlisib 2 72
0.001
 11516.0 11660.8 1643.3
-3.0
 0.991 0.988 2.827
HCC1806 BKM120 0 2 72
HCC1806 Buparlisib 2 72
0.0032
 11494.8 11660.8 1643.3
-2.49
 0.990 0.986 2.827
HCC1806 BKM120 0 2 72
HCC1806 Buparlisib 2 72
0.01
 11603.0 11660.8 1643.3
-2.0
 0.996 0.995 2.827
HCC1806 BKM120 0 2 72
HCC1806 Buparlisib 2 72
0.032
 11523.5 11660.8 1643.3
-1.49
 0.992 0.988 2.827
HCC1806 BKM120 0 2 72
HCC1806 Buparlisib 2 72
0.1
 11343.3 11660.8 1643.3
-1.0
 0.981 0.973 2.827
HCC1806 BKM120 0 2 72
HCC1806 Buparlisib 2 72
0.32
 10585.3 11660.8 1643.3
-0.495
 0.933 0.908 2.827
HCC1806 BKM120 0 2 72
HCC1806 Buparlisib 2 72
1.0
 3030.5 11660.8 1643.3
0.0
 0.242 0.260 2.827
HCC1806 BKM120 0 2 72
HCC1806 Buparlisib 2 72
3.2
 493.8 11660.8 1643.3
0.505
 -0.346 0.042 2.827
HCC1806 BKM120 0 2 72
HCC1806 BX-912 2 72
0.001
 11136.3 11641.0 1643.3
-3.0
 0.969 0.957 2.825
HCC1806 BX912 0 2 72
HCC1806 BX-912 2 72
0.0032
 11758.0 11641.0 1643.3
-2.49
 1.010 1.010 2.825
HCC1806 BX912 0 2 72
HCC1806 BX-912 2 72
0.01
 11557.5 11641.0 1643.3
-2.0
 0.995 0.993 2.825
HCC1806 BX912 0 2 72
HCC1806 BX-912 2 72
0.032
 11715.5 11641.0 1643.3
-1.49
 1.000 1.010 2.825
HCC1806 BX912 0 2 72
HCC1806 BX-912 2 72
0.1
 11604.5 11641.0 1643.3
-1.0
 0.998 0.997 2.825
HCC1806 BX912 0 2 72
HCC1806 BX-912 2 72
0.32
 11016.8 11641.0 1643.3
-0.495
 0.961 0.946 2.825
HCC1806 BX912 0 2 72
HCC1806 BX-912 2 72
1.0
 5114.5 11641.0 1643.3
0.0
 0.495 0.439 2.825
HCC1806 BX912 0 2 72
HCC1806 BX-912 2 72
3.2
 2492.8 11641.0 1643.3
0.505
 0.159 0.214 2.825
HCC1806 BX912 0 2 72
HCC1806 Alpelisib 2 72
0.001
 10768.8 11894.0 1643.3
-3.0
 0.932 0.905 2.856
HCC1806 BYL719 0 2 72
HCC1806 Alpelisib 2 72
0.0032
 10690.3 11894.0 1643.3
-2.49
 0.927 0.899 2.856
HCC1806 BYL719 0 2 72
HCC1806 Alpelisib 2 72
0.01
 10822.0 11894.0 1643.3
-2.0
 0.935 0.910 2.856
HCC1806 BYL719 0 2 72
HCC1806 Alpelisib 2 72
0.032
 11055.0 11894.0 1643.3
-1.49
 0.949 0.929 2.856
HCC1806 BYL719 0 2 72
HCC1806 Alpelisib 2 72
0.1
 11102.8 11894.0 1643.3
-1.0
 0.952 0.933 2.856
HCC1806 BYL719 0 2 72
HCC1806 Alpelisib 2 72
0.32
 11152.3 11894.0 1643.3
-0.495
 0.955 0.938 2.856
HCC1806 BYL719 0 2 72