Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)

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Cell line Drug name Experimental replicate Timepoint Drug concentration Live cell count Average live cell count, DMSO control Average live cell count (time = 0) Log10(drug concentration) GR value Relative cell count (treatment versus DMSO) Cell doublings (DMSO control) Experiment name
HCC70 MK2206 2 72
0.0032
 2410.8 2332.3 722.8
-2.49
 1.040 1.030 1.690
HCC70 MK2206 0 2 72
HCC70 MK2206 2 72
0.01
 2536.8 2332.3 722.8
-2.0
 1.100 1.090 1.690
HCC70 MK2206 0 2 72
HCC70 MK2206 2 72
0.032
 2371.0 2332.3 722.8
-1.49
 1.020 1.020 1.690
HCC70 MK2206 0 2 72
HCC70 MK2206 2 72
0.1
 2029.8 2332.3 722.8
-1.0
 0.842 0.870 1.690
HCC70 MK2206 0 2 72
HCC70 MK2206 2 72
0.32
 1610.5 2332.3 722.8
-0.495
 0.606 0.691 1.690
HCC70 MK2206 0 2 72
HCC70 MK2206 2 72
1.0
 1172.5 2332.3 722.8
0.0
 0.331 0.503 1.690
HCC70 MK2206 0 2 72
HCC70 MK2206 2 72
3.2
 1045.5 2332.3 722.8
0.505
 0.244 0.448 1.690
HCC70 MK2206 0 2 72
HCC70 PI103 2 72
0.001
 2396.8 2413.0 722.8
-3.0
 0.992 0.993 1.739
HCC70 PI103 0 2 72
HCC70 PI103 2 72
0.0032
 2457.8 2413.0 722.8
-2.49
 1.020 1.020 1.739
HCC70 PI103 0 2 72
HCC70 PI103 2 72
0.01
 2439.3 2413.0 722.8
-2.0
 1.010 1.010 1.739
HCC70 PI103 0 2 72
HCC70 PI103 2 72
0.032
 2429.8 2413.0 722.8
-1.49
 1.010 1.010 1.739
HCC70 PI103 0 2 72
HCC70 PI103 2 72
0.1
 2385.3 2413.0 722.8
-1.0
 0.987 0.989 1.739
HCC70 PI103 0 2 72
HCC70 PI103 2 72
0.32
 2072.5 2413.0 722.8
-0.495
 0.832 0.859 1.739
HCC70 PI103 0 2 72
HCC70 PI103 2 72
1.0
 1594.8 2413.0 722.8
0.0
 0.576 0.661 1.739
HCC70 PI103 0 2 72
HCC70 PI103 2 72
3.2
 753.0 2413.0 722.8
0.505
 0.024 0.312 1.739
HCC70 PI103 0 2 72
HCC70 PIK-93 2 72
0.001
 2391.5 2356.8 722.8
-3.0
 1.020 1.010 1.705
HCC70 PIK93 0 2 72
HCC70 PIK-93 2 72
0.0032
 2446.8 2356.8 722.8
-2.49
 1.040 1.040 1.705
HCC70 PIK93 0 2 72
HCC70 PIK-93 2 72
0.01
 2430.5 2356.8 722.8
-2.0
 1.040 1.030 1.705
HCC70 PIK93 0 2 72
HCC70 PIK-93 2 72
0.032
 2573.3 2356.8 722.8
-1.49
 1.110 1.090 1.705
HCC70 PIK93 0 2 72
HCC70 PIK-93 2 72
0.1
 2353.8 2356.8 722.8
-1.0
 0.999 0.999 1.705
HCC70 PIK93 0 2 72
HCC70 PIK-93 2 72
0.32
 2283.8 2356.8 722.8
-0.495
 0.963 0.969 1.705
HCC70 PIK93 0 2 72
HCC70 PIK-93 2 72
1.0
 2214.3 2356.8 722.8
0.0
 0.928 0.940 1.705
HCC70 PIK93 0 2 72
HCC70 PIK-93 2 72
3.2
 1691.8 2356.8 722.8
0.505
 0.647 0.718 1.705
HCC70 PIK93 0 2 72
HCC70 Sirolimus 2 72
0.001
 1965.0 2451.5 722.8
-3.0
 0.764 0.802 1.762
HCC70 Rapamycin 0 2 72
HCC70 Sirolimus 2 72
0.0032
 1938.3 2451.5 722.8
-2.49
 0.750 0.791 1.762
HCC70 Rapamycin 0 2 72