Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)

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Cell line Drug name Experimental replicate Timepoint Drug concentration Live cell count Average live cell count, DMSO control Average live cell count (time = 0) Log10(drug concentration) GR value Relative cell count (treatment versus DMSO) Cell doublings (DMSO control) Experiment name
HCC70 Sirolimus 2 72
0.01
 1991.8 2451.5 722.8
-2.0
 0.778 0.812 1.762
HCC70 Rapamycin 0 2 72
HCC70 Sirolimus 2 72
0.032
 1931.5 2451.5 722.8
-1.49
 0.747 0.788 1.762
HCC70 Rapamycin 0 2 72
HCC70 Sirolimus 2 72
0.1
 1925.5 2451.5 722.8
-1.0
 0.744 0.785 1.762
HCC70 Rapamycin 0 2 72
HCC70 Sirolimus 2 72
0.32
 1972.8 2451.5 722.8
-0.495
 0.768 0.805 1.762
HCC70 Rapamycin 0 2 72
HCC70 Sirolimus 2 72
1.0
 1819.5 2451.5 722.8
0.0
 0.689 0.742 1.762
HCC70 Rapamycin 0 2 72
HCC70 Sirolimus 2 72
3.2
 1812.5 2451.5 722.8
0.505
 0.685 0.739 1.762
HCC70 Rapamycin 0 2 72
HCC70 TGX221 2 72
0.001
 2272.8 2492.8 722.8
-3.0
 0.899 0.912 1.786
HCC70 TGX221 0 2 72
HCC70 TGX221 2 72
0.0032
 2297.3 2492.8 722.8
-2.49
 0.911 0.922 1.786
HCC70 TGX221 0 2 72
HCC70 TGX221 2 72
0.01
 2305.8 2492.8 722.8
-2.0
 0.915 0.925 1.786
HCC70 TGX221 0 2 72
HCC70 TGX221 2 72
0.032
 2323.5 2492.8 722.8
-1.49
 0.923 0.932 1.786
HCC70 TGX221 0 2 72
HCC70 TGX221 2 72
0.1
 1989.0 2492.8 722.8
-1.0
 0.763 0.798 1.786
HCC70 TGX221 0 2 72
HCC70 TGX221 2 72
0.32
 1756.5 2492.8 722.8
-0.495
 0.644 0.705 1.786
HCC70 TGX221 0 2 72
HCC70 TGX221 2 72
1.0
 1546.8 2492.8 722.8
0.0
 0.531 0.621 1.786
HCC70 TGX221 0 2 72
HCC70 TGX221 2 72
3.2
 1433.3 2492.8 722.8
0.505
 0.467 0.575 1.786
HCC70 TGX221 0 2 72
HCC70 Torin1 2 72
0.001
 2298.0 2391.3 722.8
-3.0
 0.954 0.961 1.726
HCC70 Torin1 0 2 72
HCC70 Torin1 2 72
0.0032
 2198.5 2391.3 722.8
-2.49
 0.905 0.919 1.726
HCC70 Torin1 0 2 72
HCC70 Torin1 2 72
0.01
 1934.5 2391.3 722.8
-2.0
 0.769 0.809 1.726
HCC70 Torin1 0 2 72
HCC70 Torin1 2 72
0.032
 1708.0 2391.3 722.8
-1.49
 0.646 0.714 1.726
HCC70 Torin1 0 2 72
HCC70 Torin1 2 72
0.1
 1466.8 2391.3 722.8
-1.0
 0.507 0.613 1.726
HCC70 Torin1 0 2 72
HCC70 Torin1 2 72
0.32
 1310.0 2391.3 722.8
-0.495
 0.411 0.548 1.726
HCC70 Torin1 0 2 72
HCC70 Torin1 2 72
1.0
 1264.5 2391.3 722.8
0.0
 0.383 0.529 1.726
HCC70 Torin1 0 2 72
HCC70 Torin1 2 72
3.2
 1172.5 2391.3 722.8
0.505
 0.323 0.490 1.726
HCC70 Torin1 0 2 72
HCC70 Torin2 2 72
0.001
 2153.8 2562.3 722.8
-3.0
 0.819 0.841 1.826
HCC70 Torin2 0 2 72
HCC70 Torin2 2 72
0.0032
 1902.0 2562.3 722.8
-2.49
 0.699 0.742 1.826
HCC70 Torin2 0 2 72
HCC70 Torin2 2 72
0.01
 1810.3 2562.3 722.8
-2.0
 0.653 0.707 1.826
HCC70 Torin2 0 2 72