Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC70 | WYE-125132 | 1 | 72 | 0.1 | 2140.8 | 3334.5 | 1279.8 | -1.0 | 0.451 | 0.642 | 1.382 | HCC70 WYE125132 0 1 72 |
| HCC70 | WYE-125132 | 1 | 72 | 0.32 | 1951.8 | 3334.5 | 1279.8 | -0.495 | 0.357 | 0.585 | 1.382 | HCC70 WYE125132 0 1 72 |
| HCC70 | WYE-125132 | 1 | 72 | 1.0 | 1975.3 | 3334.5 | 1279.8 | 0.0 | 0.369 | 0.592 | 1.382 | HCC70 WYE125132 0 1 72 |
| HCC70 | WYE-125132 | 1 | 72 | 3.2 | 1930.3 | 3334.5 | 1279.8 | 0.505 | 0.346 | 0.579 | 1.382 | HCC70 WYE125132 0 1 72 |
| HCC70 | XL147 | 1 | 72 | 0.001 | 3098.8 | 3367.3 | 1279.8 | -3.0 | 0.884 | 0.920 | 1.396 | HCC70 XL147 0 1 72 |
| HCC70 | XL147 | 1 | 72 | 0.0032 | 3408.5 | 3367.3 | 1279.8 | -2.49 | 1.020 | 1.010 | 1.396 | HCC70 XL147 0 1 72 |
| HCC70 | XL147 | 1 | 72 | 0.01 | 3449.5 | 3367.3 | 1279.8 | -2.0 | 1.030 | 1.020 | 1.396 | HCC70 XL147 0 1 72 |
| HCC70 | XL147 | 1 | 72 | 0.032 | 3433.8 | 3367.3 | 1279.8 | -1.49 | 1.030 | 1.020 | 1.396 | HCC70 XL147 0 1 72 |
| HCC70 | XL147 | 1 | 72 | 0.1 | 3620.5 | 3367.3 | 1279.8 | -1.0 | 1.110 | 1.080 | 1.396 | HCC70 XL147 0 1 72 |
| HCC70 | XL147 | 1 | 72 | 0.32 | 3513.3 | 3367.3 | 1279.8 | -0.495 | 1.060 | 1.040 | 1.396 | HCC70 XL147 0 1 72 |
| HCC70 | XL147 | 1 | 72 | 1.0 | 3495.0 | 3367.3 | 1279.8 | 0.0 | 1.050 | 1.040 | 1.396 | HCC70 XL147 0 1 72 |
| HCC70 | XL147 | 1 | 72 | 3.2 | 3554.8 | 3367.3 | 1279.8 | 0.505 | 1.080 | 1.060 | 1.396 | HCC70 XL147 0 1 72 |
| HCC70 | ZSTK474 | 1 | 72 | 0.001 | 3541.3 | 3221.8 | 1279.8 | -3.0 | 1.150 | 1.100 | 1.332 | HCC70 ZSTK474 0 1 72 |
| HCC70 | ZSTK474 | 1 | 72 | 0.0032 | 3325.5 | 3221.8 | 1279.8 | -2.49 | 1.050 | 1.030 | 1.332 | HCC70 ZSTK474 0 1 72 |
| HCC70 | ZSTK474 | 1 | 72 | 0.01 | 3399.5 | 3221.8 | 1279.8 | -2.0 | 1.080 | 1.060 | 1.332 | HCC70 ZSTK474 0 1 72 |
| HCC70 | ZSTK474 | 1 | 72 | 0.032 | 3411.0 | 3221.8 | 1279.8 | -1.49 | 1.090 | 1.060 | 1.332 | HCC70 ZSTK474 0 1 72 |
| HCC70 | ZSTK474 | 1 | 72 | 0.1 | 2604.8 | 3221.8 | 1279.8 | -1.0 | 0.705 | 0.808 | 1.332 | HCC70 ZSTK474 0 1 72 |
| HCC70 | ZSTK474 | 1 | 72 | 0.32 | 1536.0 | 3221.8 | 1279.8 | -0.495 | 0.147 | 0.477 | 1.332 | HCC70 ZSTK474 0 1 72 |
| HCC70 | ZSTK474 | 1 | 72 | 1.0 | 1164.8 | 3221.8 | 1279.8 | 0.0 | -0.068 | 0.362 | 1.332 | HCC70 ZSTK474 0 1 72 |
| HCC70 | ZSTK474 | 1 | 72 | 3.2 | 849.3 | 3221.8 | 1279.8 | 0.505 | -0.265 | 0.264 | 1.332 | HCC70 ZSTK474 0 1 72 |
| HCC70 | AS605240 | 2 | 72 | 0.001 | 2419.8 | 2466.3 | 722.8 | -3.0 | 0.979 | 0.981 | 1.771 | HCC70 AS605240 0 2 72 |
| HCC70 | AS605240 | 2 | 72 | 0.0032 | 2529.8 | 2466.3 | 722.8 | -2.49 | 1.030 | 1.030 | 1.771 | HCC70 AS605240 0 2 72 |
| HCC70 | AS605240 | 2 | 72 | 0.01 | 2383.3 | 2466.3 | 722.8 | -2.0 | 0.962 | 0.966 | 1.771 | HCC70 AS605240 0 2 72 |
| HCC70 | AS605240 | 2 | 72 | 0.032 | 2332.0 | 2466.3 | 722.8 | -1.49 | 0.938 | 0.946 | 1.771 | HCC70 AS605240 0 2 72 |
| HCC70 | AS605240 | 2 | 72 | 0.1 | 2308.5 | 2466.3 | 722.8 | -1.0 | 0.927 | 0.936 | 1.771 | HCC70 AS605240 0 2 72 |